Aspects of the present disclosure disclose a system and method for delivering for administering radiation to a patient. The method may include associating the patient with one of a plurality of coded dosage zones wherein each of the plurality of coded dosage zones corresponds to one or more values of a physical characteristic. The method may further include correlating the one of the plurality of coded dosage zones to a dose of radiation and then applying the dose of radiation to the patient.

A gas scintillation detector is designed to provide in-beam absolute dose monitoring for ion beam radiotherapy treatments employing spot or raster beam scanning, especially with microsecond-scale beam pulses. Detection of prompt primary scintillation light emitted by gas molecules excited by beam passage provides electronic signals that can be processed to yield output data proportional to delivered dose up to high dose rates, and that appear quickly enough to provide feedback to influence real-time beam intensity adjustments for subsequent steps in the beam scan. When the scintillation light is collected in multiple photo-detectors, the invention is furthermore capable of measuring spot beam position with spatial resolutions of order one millimeter.

Particle radiation therapy and planning utilizing magnetic resonance imaging (MRI) data. Radiation therapy prescription information and patient MRI data can be received and a radiation therapy treatment plan can be determined for use with a particle beam. The treatment plan can utilize the radiation therapy prescription information and the patient MRI data to account for interaction properties of soft tissues in the patient through which the particle beam passes. Patient MRI data may be received from a magnetic resonance imaging system integrated with the particle radiation therapy system. MRI data acquired during treatment may also be utilized to modify or optimize the particle radiation therapy treatment.

Interstitial brachytherapy is a cancer treatment in which radioactive material is placed directly in the target tissue of the affected site using an afterloader. The accuracy of radiation placement is monitored during the cancer treatment. The location plan for the radioactive material may be adjusted during the cancer treatment based on real-time analysis of the location and dosage of radiation measured in, at and around the target tissue of the affected site.

A method for adaptive treatment planning is provided. The method may include obtaining a planning image volume of a subject, a treatment image volume of the subject, and a first treatment plan related to the planning image volume of the subject, each of the planning image volume and the treatment image volume including an ROI of the subject. The method may also include registering the planning image volume and the treatment image volume, and determining a first contour of the ROI in the registered planning image volume and a second contour of the ROI in the registered treatment image volume. The method may also include evaluating whether an error exists in at least one of the registration or the contour determination based on the first contour and the second contour, and determining a second treatment plan with respect to the treatment image volume based on the evaluation result.

The present disclosure is directed to systems and methods for real-time control of a charged particle pencil beam system during therapeutic treatment of a patient. In an aspect, the present disclosure is directed to measuring an actual shape, an actual intensity distribution, and an actual location at isocenter of the charged particle pencil beam. The actual data is compared to model treatment data in real time to determine if a statistically significant variance occurs in which case the charged particle pencil beam can be stopped mid-treatment for correction and/or analysis.

Some embodiments are directed to a radiation dosage monitoring system including a model generation module configured to generate a 3D surface model of a portion of a patient undergoing radiation treatment, an image detector configured to detect Cherenkov radiation and any subsequent secondary and scattered radiation originating due to the initial Cherenkov radiation emitted from the patient, a processing module configured to determine estimations of radiation applied to the patient utilizing the images from the image detector and the 3D model, and to utilize the determined estimations of radiation applied to the patient together with data indicative of the orientation of a radiation beam inducing emission of the Cherenkov radiation at a time when the radiation beam was applied to generate a 3D internal representation of the location of the portions of a irradiated patient resulting in the emission of the Cherenkov radiation.

Provided is a device and method for adhering a solid state diode onto a patient and allowing for monitoring during radiation treatment. More particularly, a diode is placed onto a patient. The diode applicator disc is placed on top of the diode with the center of the diode in the transparent area of the applicator disc. The radiation therapist can verify that the diode is held on the point of interest before the applicator disc is applied to secure the diode to the patient's skin. The transparent center allows for proper visualization during the radiation treatment, and the diode measurement can be taken in real time. Preferred embodiment comprises a foam layer that surrounds the diode, a central aperture, a transparent area for visualization of the diode, and an adhesive layer for attachment to the patient's skin.

One embodiment of the present disclosure is directed to a mobile X-ray unit. The mobile X-ray unit may include an X-ray applicator for emitting an X-ray beam for irradiating an object. The mobile X-ray unit may further include a phantom-based dosimetry system configured to perform a dosimetry check of the X-ray beam. The phantom-based dosimetry system may include two sets of dose meters, each set being positioned on a surface at a distinct depth. The mobile X-ray unit may also include a dosimetry control unit configured to receive measurements from the two sets of dose meters and determine whether the dosimetry check is passed based on the measurements.

The present invention relates to advanced Cherenkov-based imaging systems, tools, and methods of feedback control, temporal control sequence image capture, and quantification in high resolution dose images. In particular, the present invention provides a system and method for simple, accurate, quick, robust, real-time, water-equivalent characterization of beams from LINACs and other systems producing external-therapy radiation for purposes including optimization, commissioning, routine quality auditing, R&D, and manufacture. The present invention also provides a system and method for rapid and economic characterization of complex radiation treatment plans prior to patient exposure. Further, the present invention also provides a system and method of economically detecting Cherenkov radiation emitted by tissue and other media in real-world clinical settings (e.g., settings illuminated by visible light).