A radiation system employs a couch top rotatable about a yaw axis to provide non-coplanar irradiation of a patient in an O-ring type of radiation machine. The radiation machine includes a source operable to produce radiation and a housing enclosing the source. The housing defines a bore and the source is rotatable at least partially around the bore. The couch top is adapted to be rotatable about a yaw axis, thereby allowing non-coplanar irradiation of at least a portion of the patient by the source. A radiation method is also provided.

The present disclosure provides a radiation therapy device and a magnetic resonance guided radiation therapy system. The radiation therapy device may include an electron gun and a curved beam deflection unit. The beam deflection unit may be configured to accelerate an electron beam emitted from the electron gun within a magnetic field. The magnetic resonance guided radiation therapy system may include a radiation therapy device and a magnetic resonance imaging (MRI) device.

A radio therapy system includes a first x-ray source. The first x-ray source is configured to produce first x-ray photons in a first energy range suitable for imaging and project the first x-ray photons onto an area designated for imaging. The system includes a second x-ray source configured to produce second x-ray photons in a second energy range higher energy than the first energy range, produce third x-ray photons in a third energy range higher energy than the first energy range, project the second x-ray photons onto the area designated for imaging, and project the third x-ray photons onto an area designated for treatment. The system includes an analytical portion configured to collect and combine data to create a composite output including at least one image, the combining based in part on a spectral analysis.

A mounting mechanism includes: two lateral supports respectively connected to two sides of a radiation head; top supports connected to tops of the lateral supports and configured to be connected to a top of a gantry; and positioning supports connected to the gantry and disposed between the lateral supports and the gantry, wherein the thicknesses of the positioning supports are adjustable. A radiotherapy device is further provided.

According to an aspect of the present disclosure, a beam control device for radiotherapy is provided. The beam control device may include an electron beam generator configured to emit an electron beam for radiotherapy toward a subject in a first direction. The beam control device may further include a first deflection device configured to generate a defocused electron beam by defocusing the electron beam in a second direction, the second direction being different from the first direction.

Systems and methods for generating a radiotherapy treatment plan using information about gantry angle-indexed dose (GAID) variation are discussed. An exemplary system can include an interface to receive a beam model for use in the radiation machine, and a processor that can determine, for the radiation machine, a GAID variation represented by a plurality of radiation doses at different gantry angles. The processor can determine a radiation treatment plan for the patient using the beam model and the GAID variation.

Systems and methods for tracking a target volume, e.g., tumor, in real-time during radiation treatment are provided. The system includes a memory to store a pre-acquired 3D image of the anatomy of interest in a first reference frame and a processor, operative coupled with the memory, to receive, from an ultrasound probe, a set-up ultrasound image of the anatomy of interest in a second reference frame. The processor further to establish a transformation between the first and second reference frames by registering the set-up ultrasound image with the pre-acquired 3D image and receive, from the ultrasound probe, an intrafraction ultrasound image of the anatomy of interest. The processor further to register the intrafraction ultrasound image with the set-up ultrasound image and track motion of the anatomy of interest based on the registered intrafraction ultrasound image.

Disclosed herein are systems and methods for monitoring calibration of positron emission tomography (PET) systems. In some variations, the systems include an imaging assembly having a gantry comprising a plurality of positron emission detectors. A housing may be coupled to the gantry, and the housing may include a bore and a radiation source holder spaced away from a patient scan region within the bore. A processor may be configured to receive positron emission data from the positron emission detectors and to distinguish the positron emission data from the radiation source holder and from the patient scan region. A fault signal may be generated when the positron emission data from the radiation source holder exceeds one or more threshold parameters or criteria.

A method for treating damaged peripheral nerves of a subject includes irradiating at least a portion of the damaged PNs with an array of x-ray microbeams having an in-beam dose sufficient to at least initiate demyelination, each of the microbeams being no greater than 0.7 mm in thickness, and separated for tissue sparing, e.g., by at least 0.05 mm, and optionally administering schwann cell progenitors (SCPs) to the irradiated portion to remyelination before or after irradiating. In-beam dose may be between about 30 to 200 Gy. The method may include irradiating using an x-ray tube of a CT scanner having a multi-aperture collimator mounted thereto and on/near the subject. The SCPs may be adult rat olfactory sphere cells or neural stem cells.

The disclosure provides systems and methods for adjusting a multi-leaf collimator (MLC). The MLC includes a plurality of cross-layer leaf pairs, each cross-layer leaf pair of the plurality of cross-layer leaf pairs includes a first leaf located in a first layer of leaves and a second leaf opposingly located in a second layer of leaves. For at least one cross-layer leaf pair, an effective cross-layer leaf gap to be formed between the first leaf and the second leaf may be determined; at least one of the first leaf or the second leaf may be caused to move to form the effective cross-layer leaf gap; and an in-layer leaf gap may be caused, based on the effective cross-layer leaf gap, to be formed between the first leaf and an opposing first leaf in the first layer. A size of the in-layer leaf gap may be no less than a threshold.