Presented systems and methods facilitate efficient and effective generation and delivery of radiation. In one embodiment, a radiation system includes a patient station, wherein the patient station includes a plurality of accelerator systems, and a microwave generation system configured to generate microwaves for the plurality of accelerators. The plurality of accelerators can be configured to provide substantially simultaneous multiple radiation beams from the plurality of accelerators. In one exemplary implementation, the microwave generation system includes a plurality of radio frequency (RF) sources, wherein respective ones of the plurality of RF sources generate separate microwave signals for corresponding respective ones of the plurality of accelerator systems, and a plurality of modulators, wherein respective ones of the plurality of modulators modulate generation of the separate microwave signals by the respective ones of the plurality of RF sources. The respective ones of the plurality of RF sources and plurality of modulators can be included in a respective plurality of RF chains, wherein respective ones of the plurality of RF chains include a respective circulator and dose rate servo. Multiple radiation beams from the respective plurality of accelerator systems are configured to be transmitted from different orientations.

The present disclosure provides a collimating body and a multi-source focusing radiation therapy head. The collimating body includes a first collimating portion and a second collimating portion. The first collimating portion and the second collimating portion are arranged side by side and closely fixed. The first collimating portion includes a first collimating hole set, and the second collimating portion includes a second collimating hole set. The first collimating portion and the second collimating portion are able to move oppositely in a direction perpendicular to a side-by-side direction, so as to align or stagger the first collimating hole set and the second collimating hole set.

Systems and methods are provided for registering images. The systems and methods perform operations comprising: receiving, at a first time point in a given radiation session, a first imaging slice corresponding to a first plane; encoding the first imaging slice to a lower dimensional representation; applying a trained machine learning model to the encoded first imaging slice to estimate an encoded version of a second imaging slice corresponding to a second plane at the first time point to provide a pair of imaging slices for the first time point; simultaneously spatially registering the pair of imaging slices to a volumetric image, received prior to the given radiation session, comprising a time-varying object to calculate displacement of the object; and generating an updated therapy protocol to control delivery of a therapy beam based on the calculated displacement of the object.

The present invention relates to the field of radiation therapy and methods, software and systems for treatment planning. A target volume of a region of a patient to be treated during a treatment of a patient in a radiation therapy unit is obtained. A first isocenter location procedure is performed including inter alia evaluating potential isocenter locations along normal directions of the surface and respective isodistance surfaces in respective starting voxels in a direction inwards from the surface, and a second isocenter location procedure is performed including inter alia identifying a median axis of the target volume or center point of the target volume, placing isocenters at locations along the median axis, and placing isocenters in the target volume based on a distance to existing isocenters and to the target surface.

The present disclosure may disclose methods and systems for treating an object. The method may include imaging an object fixed on a positioning device using an imaging device. The method may include obtaining a plan image of the object. The method may include generating information of a region of interest (ROI) of the object based on the plan image of the object. The method may include generating a treatment plan based on the information of the ROI. The treatment plan may include a plan isocenter on the plan image. The method may further include treating a target portion of the object based on the treatment plan using a treatment device. The object may be fixed on the positioning device from a moment that the object is started to fixed on the positioning device to an end of the treatment of the target portion.

To provide a BNCT treatment system capable of formulating a neutron irradiation mode based on diagnostic data on a subject to be treated. A BNCT treatment system 2, used for performing neutron capture therapy, includes: a Hexatron 3 including first to sixth neutron irradiation devices 3A to 3F which emit neutrons; and a controller 4 configured to control neutron irradiation by the first to sixth neutron irradiation devices 3A to 3F. The BNCT treatment system 2 includes: an HOP 5 configured to formulate a treatment plan (a mode for controlling neutron irradiation of the first to sixth neutron irradiation devices 3A to 3F by the controller 4) based on diagnostic data on a patient PA; an HSP 6 configured to monitor each component member; and a management unit 7 configured to manage the entire system.

Conventional single fraction 20-Gy broadbeam photonbeam or protonbeam chemo-radiosurgery does not sterilize EMT-MET cancer stem cell radiodurans but single fraction 100 to 10,000 Gy microbeam radiosurgery sterilizes them. Device and methods for microbeam chemo-radiosurgery including 250 MeV wakefield electronbeam is disclosed.

Surgery, chemotherapy and broadbeam and microbeam radiosurgery releases billions of abscopal metastasis causing, tumor specific plasma soluble proteins, cell membranes, apoptotic bodies, DNA and RNAs, exosomes like telomere-telomerase, ATM-ATM kinase and others. They and adaptive resistance to chemo-radiosurgery, paraneoplastic and non-paraneoplastic diseases causing immune complexes are removed by pulse flow combined continuous flow ultracentrifugation apheresis and immune affinity chromatography. Chemotherapy and high dose radiation exposed tumor cells and their exosomes are made sensitive to telomerase inhibiting and apoptosis inducing and least toxic epigallocatechin and to heparin bound receptors. They convert triple negative breast tumors into receptor positive tumors which open new avenues for treating most aggressive breast cancers.

This disclosure provides systems, methods, and apparatus related to ion beam therapy. In one aspect, a system includes a position sensitive detector and a collimator. The position sensitive detector configured to detect gamma rays generated by an ion beam interacting with a target. The collimator is positioned between the target and the position sensitive detector. The collimator includes a plurality of knife-edge slits, with a first knife-edge slit intersecting with a second knife-edge slit.

Embodiments of the present disclosure provide a positioning method and apparatus, and a radiation therapy system. The positioning method comprises: acquiring a current gamma angle before radiation beams of a radiation source illuminate a treatment body part; acquiring a reconstructed image corresponding to the current gamma angle, the reconstructed image being an image reconstructed according to an image of the treatment body part acquired in advance; acquiring an IGRT image of the treatment body part corresponding to the current gamma angle, the IGRT image being an image generated by an image guide system; and comparing the reconstructed image with the IGRT image to obtain a deviation of the position of the treatment body part, and sending out the deviation, so that the position of the treatment body part is adjusted according to the deviation when the deviation is greater than a preset threshold.

Removable marker implants having fiducial markers disposed on multiple elongate members extend and splay laterally outward when deployed thereby providing improved 3D localization and tracking of a portion of the patient's body for stereotactic radiosurgery. Such an approach is particularly useful for tracking of the uterus during radiosurgery treatment of uterine fibroids. Such implants can include an outer sheath that contains the multiple elongate members during delivery into the portion of the body. The elongate members can be slidably disposed within the shaft and advanced into an expanded deployed position by advancement of an applicator shaft or rod within the sheath. Marker implant can also be integrally formed implants with flexible arms having fiducial markers thereon that can be constrained in a sheath for delivery and resiliently splay laterally outward when released from the shaft. Methods of delivery and deployment are also provided.