The present disclosure generally relates to an applicator for radiotherapy and a method for determining a thickness of a scattering foil and modulator therein. According to one embodiment, an applicator for radiotherapy may comprise a housing having a hollow structure with an opening, a scattering foil disposed at an opening of the hollow structure and configured to receive a first radiation and convert a portion of the first radiation into a second radiation while scattering the first radiation, and a modulator disposed inside the hollow structure and configured to modulate an intensity of mixed radiation including the first radiation and the second radiation.

Methods for dose or treatment planning for a radiotherapy system including a radiotherapy unit are provided. A spatial dose delivered can be changed by adjusting beam shape settings, and the delivered radiation is determined using an optimization problem that steers the delivered radiation according to objectives reflecting criteria for regions of interest including at least one of: targets to be treated during treatment of the patient, organs at risk and/or healthy tissue. The method includes determining an inner set of voxels and providing a first frame description for the inner set of voxels, where the first frame description reflects criteria for the inner set of voxels. Determining an outer set of voxels encompassing the target volume and the inner set of voxels and a frame description for the outer set of voxels is provided where each reflecting criteria for the outer set of voxels. The frame descriptions are then used in the optimization problem that steers the delivered radiation.

Removable marker implants having fiducial markers disposed on multiple elongate members extend and splay laterally outward when deployed thereby providing improved 3D localization and tracking of a portion of the patient's body for stereotactic radiosurgery. Such an approach is particularly useful for tracking of the uterus during radiosurgery treatment of uterine fibroids. Such implants can include an outer sheath that contains the multiple elongate members during delivery into the portion of the body. The elongate members can be slidably disposed within the shaft and advanced into an expanded deployed position by advancement of an applicator shaft or rod within the sheath. Marker implant can also be integrally formed implants with flexible arms having fiducial markers thereon that can be constrained in a sheath for delivery and resiliently splay laterally outward when released from the shaft. Methods of delivery and deployment are also provided.

The present disclosure discloses a laser verification apparatus employed in a radiotherapeutic device which comprises a plurality of radioactive sources, a collimator comprising a plurality of collimating holes, and a couch. The radioactive sources are capable of aligning in respect to the collimating holes respectively. The laser verification apparatus comprises: a positioning plate, fixed on the multi-source radiotherapy equipment and arranged between the radiation sources and the collimators; a movable plate, arranged on and movable relative to the positioning plate, and provided with a plurality of first mounting holes and a plurality of second mounting holes, which are arranged one by one, alternately, the movable plate is configured to switch the plurality of first mounting holes or the plurality of second mounting holes to positions corresponding to the plurality of collimators; a plurality of laser emitters respectively received in the second mounting holes, and an acquisition analyzer arranged on the couch and configured to acquire the light beams emitted by the laser emitters and perform data analysis.

An apparatus for identifying and quantifying image distortions within a patient magnetic resonance image set comprises a structure of magnetic resonance compatible materials with a high level of rigidity, where the structure is configured to cover the whole image volume of the brain region of the patient and sized to fit within a brain magnetic resonance coil when worn by a patient. A plurality of magnetic resonance fiducial markers is placed on the structure, thereby permitting the measurement of three-dimensional distances between the markers when the patient undergoes a magnetic resonance imaging procedure. Also presented is a process for identifying and quantifying image distortions within a patient magnetic resonance image set using the apparatus where the geometrical distortion is quantified and compared with a set threshold or a standard image.

Disclosed herein are methods for patient setup and patient target region localization for the irradiation of multiple patient target regions in a single treatment session. Virtual localization is a method that can be used to register a patient target region without requiring that the patient is physically moved using the patient platform. Instead, the planned fluence is updated to reflect the current location of the patient target region by selecting a localization reference in the localization image, calculating a localization function based on the localization reference point, and calculating the delivery fluence by convolving the localization function with a shift-invariant firing filter. Mosaic multi-target localization partitions a planned fluence map for multiple patient target regions into sub-regions that can be individually localized. De-coupled multi-target localization involves generating a separate planned fluence map for each target but constraining a cumulative fluence map to ensure dosimetric goals are met.

The invention provides a non-invasive method for treatment of arrhythmia. In a first aspect, a method for treatment of atrial fibrillation in a heart of a patient comprises directing radiation from outside the patient toward one or more target treatment regions of the heart so as to inhibit the atrial fibrillation. The radiation may induce isolation of a pulmonary vein.

A method of treating or preventing adverse outcomes associated with tissue plasminogen activator (tPA) administration, cerebral edema-related side effects, cerebral edema associated with radiation therapy, or migraine headaches by administering an effective amount of a SUR1-TRPM4 channel inhibitor, such as glyburide, and optionally the co-administration of a second therapeutically active agent, to a subject in need thereof. Adverse outcomes associated with tPA include cerebral hemorrhage, cerebral edema, physical impairment or death. The administration of the SUR1-TRPM4 channel inhibitors occurs prior to the radiation therapy, during the radiation therapy, after the radiation therapy, or combinations thereof. The SUR1-TRPM4 channel inhibitor is administered prior to surgical excision of a brain tumor, CAR-T therapy, or administration of flutarabine. Alternatively, or in addition, the SUR1-TRPM4 channel inhibitor is administered prior the onset of the cerebral edema-related side effects.

A radiation treatment device is provided. The device includes an imaging unit and a single radiotherapy unit adjacent to a second end of the imaging unit. The imaging unit includes a first opening at a first end of the imaging unit adapted to receive a patient; at least one imaging source; and at least one imager arranged opposite the imaging source. The imaging source and the imager are rotatable about the rotational axis. The radiotherapy unit includes a source body carrying radioactive sources and a collimator having collimation channels. The collimation channels permit treatment beams emitted by the radioactive sources to be projected inside the imaging unit and focused at an intersection point located within an imaging beam of the imaging unit. The source body and the collimator are arranged concentric about the rotational axis and close a second opening at the second end.

A radiotherapy device and a control driving method thereof are provided. The radiotherapy device includes a radiation source apparatus having a plurality of radiation sources, a source carrier and a collimator. The source carrier includes a source box and a source box region conforming to a shape of the source box, the source box is detachably fixed at the source box region, the plurality of radiation sources are mounted in the source box, the source box is provided with a first connecting part, the source carrier is provided with a second connecting part, and the first connecting part is configured to connect the second connecting part.