A method for calibrating an alignment device includes obtaining one or more projection images of a phantom having one or more surface indicators, the one or more surface indicators indicating a first coordinate system relating to the phantom, an origin of the first coordinate system overlapping with a calibration point of the phantom. The method further includes determining a difference between the first coordinate system and a second coordinate system based on the one or more projection images, the second coordinate system being relating to a medical system. The method further includes adjusting the phantom to an updated state according to the difference between the first coordinate system and the second coordinate system such that the first coordinate system overlaps with the second coordinate system. The method also includes adjusting an alignment device according to the one or more surface indicators in the updated state.

The invention discloses a radiotherapy device and method, the invention uses the treatment reference point of the photon therapy component, that is, the isocenter as the reference point of the entire system, so that the axis of the proton beam emitted by the proton treatment equipment (proton therapy component) or the heavy ion beam emitted by the heavy ion treatment equipment (heavy ion therapy component) always passes through the reference point, then the two can simultaneously or separately treat patients who have successfully placed one time. The treatment plan can be optimized, and the respective treatment systems of the two treatment systems can be combined. Advantages, to complete the treatment together, especially for some complex cases, the combination of the two can better complete the treatment task at a lower cost.

The present disclosure is directed towards a treatment planning system for use in a stereotactic radiotherapy system. In particular, the disclosed systems and methods may be used for generating a treatment plan and/or verifying an existing treatment plan. Moreover, the disclosed systems and methods may be suitable for use in a clinical setting. A method for verifying a treatment plan of a stereotactic radiotherapy device may include the steps of receiving a treatment plan, generating a second treatment plan by applying a modified monte-carlo method to regions of interest in the treatment plan, and identifying discrepancies between the received treatment plan and the generated second treatment plan.

The present disclosures describes a remotely controlled stereotactic radiotherapy system. The system may include a gamma-ray irradiation system for radioablation of a target region of human tissue, the system having an irradiating unit configured to produce a radiation field, and a processor remote from the gamma-ray irradiation system configured to control the dosage and position of the radiation field applied to the target region.

An apparatus includes a first multileaf collimator comprising a plurality of pairs of beam-blocking leaves each comprising an end portion. The end portions of the beam-blocking leaves of one pair are contoured to allow forming a first aperture when the beam-blocking leaves of the pair are closed. The first aperture has a closed shape such as a circle in a beam's eye view.

A method of treating or preventing adverse outcomes associated with tissue plasminogen activator (tPA) administration, cerebral edema-related side effects, cerebral edema associated with radiation therapy, or migraine headaches by administering an effective amount of a SUR1-TRPM4 channel inhibitor, such as glyburide, and optionally the co-administration of a second therapeutically active agent, to a subject in need thereof. Adverse outcomes associated with tPA include cerebral hemorrhage, cerebral edema, physical impairment or death. The administration of the SUR1-TRPM4 channel inhibitors occurs prior to the radiation therapy, during the radiation therapy, after the radiation therapy, or combinations thereof. The SUR1-TRPM4 channel inhibitor is administered prior to surgical excision of a brain tumor, CAR-T therapy, or administration of flutarabine. Alternatively, or in addition, the SUR1-TRPM4 channel inhibitor is administered prior the onset of the cerebral edema-related side effects.

In the field of radiotherapy, methods for dose or treatment planning for a radiation therapy system having a collimator, includes determining shots to be delivered during said treatment, each shot being associated with an isocenter and being modelled by a spatial dose volume distribution of radiation, the shape of said spatial distribution depending on the specific collimator setting and said selected dose level, including selecting isocenter positions within a target in a predetermined angle range; evaluating each isocenter based on predetermined conditions; selecting at least a specific collimator and sector setting for each isocenter based on the evaluation; calculating a dose for the selected isocenters; repeating the steps until at least one stopping criteria has been reached, wherein a final set of isocenters are provided; and using the final set of isocenters in treatment planning.

The present disclosure provides a microwave transmission method and a single-input multiple-output waveguide microwave system based on frequency control, an electronic device. The method includes: adjusting frequency of an input microwave, each of different input microwaves with different frequencies being input microwave of the single-input multi-output waveguide microwave system; assigning the input microwave to a target output port among multiple output ports of the single-input multiple-output waveguide microwave system, according to the frequency of the input microwave; and performing microwave output through the target output port.

Provided is a fully-spherical radiation therapy system. The fully-spherical radiation therapy system includes a multi-degree-of-freedom robot, a linear accelerator and a double-image-guided positioning mechanism. The double-image-guided positioning mechanism includes four ray sources and two ray detectors, and the four ray sources include a first ray source, a second ray source, a third ray source and a fourth ray source. An intersection of two beams emitted by the first ray source and the second ray source is a low-level treatment center, an intersection of two beams emitted by the third ray source and the fourth ray source is a high-level treatment center, and the low-level treatment center and the high-level treatment center form a fully-spherical treatment space for multiple treatment nodes of a spherical center.

An irradiation apparatus comprises a plurality of ionising radiation source points (122) configured to output ionising radiation. The plurality of ionising radiation source points (122) is an array distributed around an irradiation volume (140). The array of ionising radiation source points (122) is configured to direct ionising radiation inwardly to the irradiation volume (140). A transport apparatus (130) is configured to support at least one sample (138) to be irradiated. The transport apparatus (130) is configured to transport samples along a linear path through the irradiation volume (140).