A method for treating a cancerous tumor, by implanting in the cancerous tumor as least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon of at least 10 Mega becquerel (MBq) hour, per centimeter length. Optionally, the sources are implanted in an array of sources, each source separated from its neighboring sources in the array by not more than 4.5 millimeters.

A method for treating a tumor, comprising identifying a tumor as a breast cancer or prostate cancer tumor and implanting in the tumor identified as a breast cancer or prostate cancer tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon between 3.5 Mega becquerel (MBq) hour and 8 MBq hour, per centimeter length.

A method for treating a tumor, comprising identifying a tumor as a melanoma tumor and implanting in the tumor identified as a melanoma tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon between 3.4 Mega becquerel (MBq) hour and 8.6 MBq hour, per centimeter length.

A system for monitoring intensity of a particle beam can include one or more radio-frequency (RF) detectors coupled to a signal analyzer that can be placed outside the radiation field of the particle beam. Each RF detector can include a gas-filled RF cavity coupled to one or more gas-filled waveguides. The signal analyzer can self-calibrate before the particle beam is turned on for determining one or more absolute intensities of the particle beam when the particle beam is present.

Embodiments of systems, devices, and methods relating to a beam system. An example beam system includes a charged particle source configured to generate a beam of charged particles, a pre-accelerator system configured to accelerate the beam, and an accelerator configured to accelerate the beam from the pre-accelerator system. The pre-accelerator system can cause the beam to converge as it is propagated from the source to an input aperture of the accelerator. The pre-accelerator system can further reduce or eliminate source disturbance or damage caused by backflow traveling from the accelerator toward the source.

The present relates to device for ultra-high dose rate radiation treatment to a patient, comprising: —a radiation source for providing a radiation beam, and —a linear accelerator for accelerating said radiation beam until a predetermined energy, and —a beam delivery module for delivery the accelerated radiation beam. The device is arranged for generating an accelerated radiation beam having a predetermined energy between about 50 MeV and about 250 MeV, to deliver rate radiation dose of at least 10 Gy, during an overall time less than about 200 ms in order to generate a radiation field for treating a target volume of at least about 30 cm3, with said ultra-high dose rate radiation dose and/or a target volume located at least about 5 cm deep in the tissue of the patient with said ultra-high dose rate radiation dose.

An irradiating device, configured for irradiating a target, includes a 6-axis arm, an irradiating system positioned at the free end of the 6-axis arm, a manipulating handle, at least one load sensor placed between the manipulating handle and the 6-axis arm, and a control-actuation unit. The irradiating system includes a microwave frequency source and a radiation source supplied by the microwave frequency source. The manipulating handle is fastened to the radiation source. The control-actuation unit is configured to receive information from the load sensor and control the 6-axis arm according to the information received from the load sensor.

The invention is related to particle induced radiography system, comprising a particle radiation source device, implant module, external detector device, central module and other controls, in which the implant module comprises active and/or passive components in tandem with the readout electronics and communication chosen to measure the beam properties and to generate and detect secondary gamma photons from the nuclear interactions, the external detector device provides a position sensitive gamma detector with a high detection efficiency, good spatial resolution and a relatively large field of view necessary for particle treatments useful in monitoring both the implanted device and the patient anatomical areas under treatment, and the external detector device can also be used to perform 3D spectral imaging on any material samples using proton beam as a probe.

A correlation between a CT value and a water equivalent thickness ratio distribution for each patient can be corrected without increasing a treatment time, and more accurate treatment can be realized. A treatment planning system 112 which generates a treatment plan for irradiating an irradiation target with a particle beam calculates a correction amount of a water equivalent thickness ratio of a first treatment plan created in advance, calculates a water equivalent thickness ratio distribution based on the correction amount and the first treatment plan, and creates a second treatment plan from the water equivalent thickness distribution.

A particle therapy system includes a building having a first floor and second floors and, a particle beam generator installed on the first floor and configured to generate a particle beam, a first transport system configured to transport a particle beam from the particle beam generator to a first irradiation system in a first treatment room, and a second transport system configured to transport a particle beam to a second irradiation system in a second treatment room, branched from the first transport system, via a second floor. The second transport system has a first bending magnet that bends a particle beam to the direction of the second floor different from the installation surface of the particle beam generator. The building has a shielding wall configured to shield the first floor and the second floor and the second transport system is provided penetrating the shielding wall.