Systems and methods for generating a beam model for radiotherapy treatment planning are discussed. An exemplary system includes a memory to store a trained deep learning model, and a processor circuit to generate a beam model. The deep learning model can be trained to establish a relationship between machine scanning data and values of beam model parameters, and validated for accuracy. The processor circuit can receive machine scanning data indicative of a configuration or an operation status of the radiation therapy device, apply the machine scanning data to the trained deep learning model to determine values for the beam model parameters, and generate a beam model based on the determined values of the plurality of beam model parameters. The beam model may be provided to a user, or a treatment planning system.

The embodiments of the present disclosure provide a radiation therapy device. The radiation therapy device may comprise a beam generating device, a scanning magnet, and one or more focusing magnets. The beam generating device may be configured to generate a charged particle beam. The scanning magnet may be configured to diverge the charged particle beam. The one or more focusing magnets may be configured to deflect the charged particle beam diverged by the scanning magnet.

An electron applicator, which is used along with a linear accelerator in a FLASH radiotherapy treatment program, includes an integrated dosimeter for accurately measuring the FLASH radiation levels, and an interchangeable high-density polymer cutout which can be easily, inexpensively, and accurately formed to match the irregular shape of a tumor.

Presented systems and methods enable efficient and effective radiation planning and treatment, including accurate and convenient transmission of the radiation towards a tissue target. In one embodiment, a radiation system includes an electron gun, a bend magnet, a scan control component, and an electron beam entry angle control component. The electron gun is configured to generate electrons. The linear accelerator is configured to accelerate the electrons in an electron beam. The bend magnet is configured to bend the path of the electron beam. The scan control component controls movement of the electron beam in a scan pattern. The electron beam entry angle control component is configured to control the entry angle of the electron beam.

Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.

The present invention relates to the treatment of cancer by irradiation by high energy photons, wherein the cancer has been infused with a heavy metal. The invention further relates to the use of pair-production for increased cancer cell destruction.

Disclosed herein is an imaging system for a radiotherapy device which is configured to provide therapeutic radiation to a patient via a source of therapeutic radiation. The imaging system comprises a source of imaging radiation, a CBCT panel detector, and a CT detector, wherein the source of imaging radiation is configured to be adjustable such that in a first configuration it is configured to emit imaging radiation towards the CT detector and in a second configuration it is configured to emit imaging radiation towards the CBCT detector.

According to some aspects, a monochromatic x-ray source is provided. The monochromatic x-ray source comprises an electron source configured to generate electrons, a primary target arranged to receive electrons from the electron source to produce broadband x-ray radiation in response to electrons impinging on the primary target, and a secondary target comprising at least one layer of material capable of producing monochromatic x-ray radiation in response to incident broadband x-ray radiation emitted by the primary target.

A radiotherapy apparatus for an animal comprises a treatment part including an accommodation space for placing an animal, an irradiation part including an electron generator and a linear accelerator coupled to one side of the electron generator and disposed in a direction perpendicular to the treatment part, the linear accelerator being configured to emit radiation toward the treatment part, and an image acquisition part located at a preset interval from the treatment part along an irradiation direction of the radiation and configured to obtain an image of an irradiation area when the radiation is applied, wherein the radiation has an output of 1 MeV to 2 MeV so as to be applied to a diseased part located within a predetermined distance range from epidermis of the animal.

Certain configurations of an infusion device are described. In some examples, the infusion device may comprise an enclosure that can absorb radiation from a radioisotope material within the enclosure. The enclosure can also be configured to permit administration of the radioisotope material within the enclosure to a human in need of treatment for a condition such as cancer.