A method for treating a diseased site in a human or animal body is provided which includes injecting in a diseased site one or more phosphors which are capable of emitting ultraviolet or visible light into the body;

infusing the diseased site with a photoactivatable drug;

applying an initiation energy from an initiation energy source comprising an x-ray, gamma ray, or electron source to thereby initiate emission of ultraviolet or visible light into the body; and

controlling a dose of the initiation energy with a processor to produce (i) a cytotoxicity inside the diseased site of greater than 20% or (ii) a day-25 stable tumor volume,

wherein the processor is programmed to apply the initiation energy in a pulsed manner, wherein the initiation energy is delivered in either (i) a radiograph mode, or (ii) a pulsed fluoroscopy mode.

The disclosure pertains to a strontium-90 sealed radiological or radioactive source, such as may be used with treatment of the eye or other medical or industrial processes. The sealed radiological source includes a radiological insert within an encapsulation. The encapsulation may include increased shielding in the center thereof.

Apparatus for planning a diffusing alpha-emitter radiation therapy (DaRT) treatment session. The apparatus includes an output interface and a memory configured with a plurality of tables which provide an accumulated measure of radiation over a specific time period, due to one or more types of DaRT radiotherapy sources which emit daughter radionuclides from the source, for a plurality of different distances and angles relative to the DaRT radiotherapy source. In addition, a processor is configured to receive a description of a layout of a plurality of DaRT radiotherapy sources in a tumor, to calculate a radiation dose distribution in the tumor responsive to the layout, using the tables in the memory, and to output feedback for the treatment responsive to the radiation dose distribution, through the output interface.

Methods, devices and systems for ultra-high dose radiotherapy are disclosed. The described techniques rely in-part on active switching control of a photoconductive switch during the time the accelerator is accelerating charged particles to produce the output radiation at the desired dose rates. One radiotherapy system includes a particle accelerator configured to receive charged particles from a pulsed source. The particle accelerator includes a pipe configured to allow the charged particles to pass through as a beam, a magnetic core positioned proximate to the pipe and coupled to the pulsed source, and at least one multilayer insulator positioned adjacent to the pipe and the magnetic core. The system also includes a photoconductive switch coupled to the particle accelerator and configured to supply the particle accelerator with a plurality of voltage pulses.

Systems and devices for applying radiation to a target area, for example for maintaining functioning drainage blebs or functioning drainage holes in the eye, e.g., to reduce intraocular pressure (IOP) of an eye being treated for glaucoma. The systems and devices of the present invention provide for the application of beta radiation to the target area, wherein the beta radiation can function to inhibit or reduce the inflammation and/or fibrogenesis that may occur after insertion of an implant into the eye or introduction of a hole for the purpose of draining aqueous humor to maintain a healthy intraocular pressure. By reducing inflammation and/or fibrogenesis, the implant, the hole, the blebs, or other related structures or tissues can remain functioning appropriately.

An example computer-implemented method for tuning a beam spot in a radiation therapy system based on radiation field measurements has been disclosed. The example method includes configuring an electron beam to generate a first beam spot on an electron-beam target of the radiation therapy system, determining a value for one or more radiation field quality metrics for a first radiation beam that originates from the first beam spot, and based on the value, determining whether the first radiation beam is outside a specified quality range.

An example computer-implemented method for tuning a beam spot in a radiation therapy system has been disclosed. The example method includes configuring an electron beam to generate a first beam spot on an electron-beam target of the radiation therapy system, generating, using an imager of the radiation therapy system, a first plurality of projection images of the first beam spot, wherein each of the projection images of the first beam spot is generated with a line of sight blocked between the imager and a different respective portion of the beam spot, based on the first plurality of projection images, determining a value for one or more beam spot quality metrics associated with the first beam spot, and based on the value, determining whether the first beam spot is outside a specified quality range.

In a case where a start current value is higher than a target current value, a control unit performs a control to lower a current value from the start current value to the target current value. In addition, in a case where the start current value is equal to or lower than the target current value, the control unit controls to raise the current value from the start current value to the format current value higher than the target current value, and then lower the current value to the target current value. In this manner, regardless of the value of the predetermined current value before the current value is changed, the current value reaches the target current value in a descending manner. As a result, the coil magnetization magnetic field when the target current value is reached can be kept in the same state.

A set of magnetic elements is used in the beamline of a charged particle-based radiation therapy machine instead of scattering foils. The set of magnetic elements is located between the exit of the linear accelerator and the isocenter or patient, and is used for shaping and defocusing a charged particle beam used for charged particle-based treatment modalities.

The present disclosure discloses a method and a system for determining an energy spectrum of an incident electron beam. The method includes obtaining a plurality of deflection currents of a beam deflection device; for each of the plurality of deflection currents, determining an energy range of an ejected electron beam, and determining a target current of a target generated by the ejected electron beam irradiating the target, wherein the ejected electron beam is emitted from an output of the beam deflection device after the incident electron beam enters the beam deflection device. The method also includes determining the energy spectrum of the incident electron beam based on the energy ranges of the plurality of ejected electron beams and the corresponding target currents.