The present disclosure generally relates to the field of radiation treatment. More specifically, the present disclosure generally relates to methods and radiation treatment systems for facilitating a multimodal radiation therapy treatment plan, in particular a multimodal radiation therapy plan employing a combined photon beam and electron beam radiation treatment. According to one example embodiment described in the disclosure, a method may comprise obtaining information related to a set of candidate beam types for the combined photon beam and electron beam radiation treatment; comparing the set of candidate beam types against a selection criterion to establish a subset of beam types from the candidate beam types; and generating the combined photon beam and electron beam radiation treatment plan utilizing the thus established subset of beam types.

In the present disclosure, embodiments of microbead containment systems and containment methods are disclosed. The microbead containment system may include a microsphere container, which includes walls that define a containment space in the microsphere container, and microspheres within the containment space. The walls may include at least one magnetic component configured to produce a magnetic field within the containment space. The microspheres may include a diamagnetic material. The method of containing radioactive microspheres may include loading a plurality of microspheres comprising a diamagnetic material in a container comprising one or more magnetic components. The microspheres contained in the microsphere container interact with the magnetic field in a manner that prevents direct contact of the microspheres and the microsphere container.

In the present disclosure, embodiments of flaring tip microcatheters, methods of deploying flaring tip microcatheters, and embolization treatment methods are disclosed. The flaring tip microcatheter may include a hollow shaft having a shaft lumen defined therein, a core disposed within the shaft lumen, and a tip comprising at least two petals affixed to a distal end of the core, the at least two petals comprising at least two wires wherein the core is hollow and defines a core lumen. The at least two wires may be configured to pull the at least two petals to form a flared configuration of the tip. The flared configuration of the tip may allow for laminar flow of a therapeutic agent distally from the tip.

Systems and methods provide a radiotherapy treatment by focusing an electron beam on an x-ray target (e.g., a tungsten plate) to produce a high-yield x-ray output with improved field shaping. A modified electron beam spatial distribution is employed to scan the x-ray target, such as a 2D periodic beam path, which advantageously lowers the temperature of the x-ray target compared to typical compact beam spatial distribution. As a result, the x-ray target can produce a high yield x-ray output without sacrificing the life span of the x-ray target. The use of a 2D periodic beam path allows a much colder x-ray target functioning regime such that more dosage can be applied in a short period of time compared to existing techniques.

A multi-robotic arm apparatus for intraoperative radiotherapy is provided. The apparatus may comprise a chassis, a main robotic arm mounted on the chassis for moving a radiation head installed at an end thereof, a first robotic arm mounted on the chassis having a first robotic arm end gripper for gripping an imaging device or a treatment applicator; and a second robotic arm mounted on the chassis having a second robotic arm end gripper for gripping a simulation applicator.

A system (1) includes a device (12, 116 or 118) with memory with spectral volumetric image data generated by a spectrally configured computed tomography scanner including a radiation source and a radiation detector and an image guided system (14) configured to employ the spectral volumetric image data for an image guided procedure. A computer readable medium is encoded with computer executable instructions, where the computer executable instructions, when executed by a processor, causes the processor to: obtain spectral volumetric image data generated by a spectrally configured computed tomography scanner including a radiation source and a radiation detector, and employ the spectral volumetric image data for an image guided procedure. A method includes receiving spectral volumetric image data generated by a spectrally configured computed tomography scanner including a radiation source and a radiation detector, and utilizing he spectral volumetric image data for an image guided procedure.

The present disclosure relates to novel radiation-triggered controlled release drug compositions, and methods to make and use the radiation-triggered controlled release drug compositions. The radiation-triggered controlled drug release nanoparticle formulations may be used to achieve maximum bioavailability and minimum adverse effects of the chemo drugs in chemo radio combination therapy treatment of locally advanced solid tumors.

Apparatus and methods for controlling a radiotherapy electron beam. Exemplary embodiments provide for focusing the electron beam at different depths by altering parameters of a plurality of magnets. Exemplary embodiments can also provide for focusing the electron beam at different depths while maintaining the energy level of the electron beam at a consistent level.

The uses of the disclosed copper-cysteamine (Cu-Cy) complex for methods for treating Gram-positive and Gram-negative infections in subjects and for disinfecting a surface are disclosed. In addition, the disclosed Cy-Cy nanoparticles provide Fenton-like reactions in vivo, in vitro and ex vivo.

A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.