Presented systems and methods enable efficient and effective robust radiation treatment planning and treatment, including analysis of dose rate robustness. In one embodiment, a method comprising accessing treatment plan information, accessing information corresponding to an uncertainty associated with implementation of the radiation treatment plan, and generating a histogram, wherein the histogram conveys a characteristic of the treatment plan including an impact of the uncertainty on the characteristic. The histogram can be a dose rate volume histogram and can be utilized to test a degree of robustness of a treatment plan (e.g., including allowance for uncertainty scenarios, etc.). The uncertainty can be associated with potential variation associated with tolerances (e.g., radiation system/machine performance tolerance, patient characteristic tolerances, etc.) and set up issues (e.g., variation in initial system/machine set up, variation patient setup/position, etc.)

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

A radiotherapy dose rate monitor system includes an electrode configured to be impinged by radiotherapy radiation, and a current measurement circuit configured to measure a current through the electrode. An emission of secondary electrons emitted from the electrode provides a majority of current through the electrode.

The present disclosure provides a radiation therapy device and a magnetic resonance guided radiation therapy system. The radiation therapy device may include an electron gun and a curved beam deflection unit. The beam deflection unit may be configured to accelerate an electron beam emitted from the electron gun within a magnetic field. The magnetic resonance guided radiation therapy system may include a radiation therapy device and a magnetic resonance imaging (MRI) device.

The IORT system includes a moveable cart, a robot arm assembly coupled to the cart, at least one applicator fixed relative to a patient, a treatment head coupled to the robot arm assembly for selective alignment with the applicator in a soft-docking procedure, and a haptic control assembly on the treatment head. A plurality of arm members is pivotally coupled to each other to provide at least five axes of movement for increased positioning flexibility and the enhanced flexibility increases the reach of the treatment head for accurate alignment. The alignment follows a two-stage process with a coarse alignment performed by the haptic control assembly to position a sensor array on the treatment head within detection range of an endcap on the applicator. Final alignment is autonomous employing range data from the sensor array to accurately position the treatment head with respect to the applicator.

The present relates to device for ultra-high dose rate radiation treatment to a patient, comprising: —a radiation source for providing a radiation beam, and —a linear accelerator for accelerating said radiation beam until a predetermined energy, and —a beam delivery module for delivery the accelerated radiation beam. The device is arranged for generating an accelerated radiation beam having a predetermined energy between about 50 MeV and about 250 MeV, to deliver rate radiation dose of at least 10 Gy, during an overall time less than about 200 ms in order to generate a radiation field for treating a target volume of at least about 30 cm3, with said ultra-high dose rate radiation dose and/or a target volume located at least about 5 cm deep in the tissue of the patient with said ultra-high dose rate radiation dose.

An irradiating device, configured for irradiating a target, includes a 6-axis arm, an irradiating system positioned at the free end of the 6-axis arm, a manipulating handle, at least one load sensor placed between the manipulating handle and the 6-axis arm, and a control-actuation unit. The irradiating system includes a microwave frequency source and a radiation source supplied by the microwave frequency source. The manipulating handle is fastened to the radiation source. The control-actuation unit is configured to receive information from the load sensor and control the 6-axis arm according to the information received from the load sensor.

According to an aspect of the present disclosure, a beam control device for radiotherapy is provided. The beam control device may include an electron beam generator configured to emit an electron beam for radiotherapy toward a subject in a first direction. The beam control device may further include a first deflection device configured to generate a defocused electron beam by defocusing the electron beam in a second direction, the second direction being different from the first direction.

The present disclosure may provide a system for radiotherapy planning. The system may obtain planning information relating to at least one beam to be delivered to a subject in a treatment of the subject. The system may also generate an input of a fluence map generation model based on the planning information. For each of the at least one beam, the system may further generate at least one deliverable fluence map relating to at least one segment of the beam based on the input and the fluence map generation model.

The present disclosures relates to an ion beam assembly where a relatively small deflection angle (approximately 15° from the center of the beam line) is used in conjunction with two beam dumps located on either side of the beam. In some embodiments, the combination of the two beam dumps and the magnet assembly can provide an ion beam filter. In some embodiments, the resulting system provides a smaller, safer and more reliable ion beam. In some embodiments, the ion beam can be a proton beam.