Provided herein are methods relating to administering a dendritic cell activating therapy as an adjunct to radiation therapy or an energy-based therapy for treating a tumor or cancer in an individual.

The invention provides a device for the production, moderation and configuration of a neutron beam, comprising: an inlet opening (1) through which a proton beam is directed; a target (2) against which the proton beam is accelerated in order to generate neutrons; a moderator (3) to bring the neutrons to energies of the epithermal range; a reflective cover (4) surrounding the moderator (3); a filtration stage (5); an outlet opening (6) for the neutron beam, and a shield (7) to suppress the neutrons and gamma-radiation that do not exit the device via said outlet opening. The filtration stage (5) comprises at least three layers to filter respectively: rapid neutrons, thermal neutrons and gamma-radiation The invention is of use in neutron capture therapies, and more specifically, in boron therapies.

Provided is a radiation detection system for improving the accuracy of a neutron beam irradiation dose for a neutron capture therapy system. The neutron capture therapy system includes a charged particle beam, a charged particle beam inlet for passing the charged particle beam, a neutron generating unit for generating the neutron beam by means of a nuclear reaction with the charged particle beam, a beam shaping assembly for adjusting flux and quality of the neutron beam, and a beam outlet adjoining to the beam shaping assembly, the radiation detection system includes a radiation detection device arranged within the beam shaper or outside the beam shaping assembly, the radiation detection device is used for real-time detection of the overflowing neutron beam by the neutron generating unit or the generated γ-ray after the nuclear reaction of the charged particle beam with the neutron generating unit.

Embodiments of systems, devices, and methods relate to controlling beams for use in beam systems. An example method of controlling a travel path of a beam includes propagating a beam along a first path from an entry point of a dipole magnet through a non-gradient portion of the dipole magnet until the beam bends toward a first beam travel path of multiple beam travel paths of the dipole magnet. The example method further includes propagating the beam along the first beam travel path through a gradient portion of the dipole magnet to focus the beam for propagation to a downstream target. Embodiments further permit a compact beam system such that a series of magnets can be used to create a path that accommodates shielding to minimize the footprint of the beam system for facilities that may not otherwise support large systems due to space and safety constraints.

It is an object to provide an imaging method and system. According to an embodiment, an imaging method comprises emitting neutrons into a material, wherein the material converts at least part of the emitted neutrons into a first plurality of gamma ray photons, and wherein at least part of the emitted neutrons pass through the material. Based on the neutrons passed through the material and the gamma ray photons, at least one property of the material can be deduced. An imaging method and an imaging system are provided.

A method that produces high energy charged particles that may be used to destroy cancer cells contained in cancerous tissues. The device uses electronic neutron generators to produce neutrons with energies that have a high probability to interact with a therapeutic source comprised of a reactive material with an outer layer of a material having a high atomic number such as Platinum or Gold. The reaction produces high energy electrons, and in some cases other charged particles with relatively short half-lives, which can destroy the cancerous cells, without seriously damaging the surrounding healthy tissue.

The present disclosure provides a positioning assembly for a radiation irradiation system. The positioning assembly includes a shielding body made of polymer and radiation shielding material capable of shielding the radiation and a sealing bag for accommodating the shielding body, when the target to be irradiated is placed on the positioning assembly, the positioning assembly is recessed with a shape of the target at the position where the target is placed and forms a contour corresponding to the target to position the target to be irradiated.

Embodiments of systems, devices, and methods relate to a beam system. An example beam system includes a charged particle source configured to generate a beam of charged particles, a pre-accelerator system configured to accelerate the beam, and an accelerator configured to accelerate the beam from the pre-accelerator system. The pre-accelerator system can cause the beam to converge as it is propagated from the source to an input aperture of the accelerator. The pre-accelerator system can further reduce or eliminate source disturbance or damage caused by backflow traveling from the accelerator toward the source.

An energy radiation treatment method comprises: administering a medicinal agent to an affected part; performing energy radiation with a predetermined energy on the affected part; and confirming therapeutic effects by the energy radiation on the affected part, wherein in the administering, a determination based on at least one ultrasound image based on ultrasound waves reflected from the affected part is performed.

Provided is a radiation detection system for improving the accuracy of a neutron beam irradiation dose for a neutron capture therapy system. The neutron capture therapy system includes a charged particle beam, a charged particle beam inlet for passing the charged particle beam, a neutron generating unit for generating the neutron beam by means of a nuclear reaction with the charged particle beam, a beam shaping assembly for adjusting flux and quality of the neutron beam, and a beam outlet adjoining to the beam shaping assembly, the radiation detection system includes a radiation detection device arranged within the beam shaper or outside the beam shaping assembly, the radiation detection device is used for real-time detection of the overflowing neutron beam by the neutron generating unit or the generated γ-ray after the nuclear reaction of the charged particle beam with the neutron generating unit.