An applicator for intraoperative radiotherapy with low-energy X-ray radiation includes an applicator body, an air-permeable outer surface with a circumferential outer face and with a distal end, a receiving device which is arranged at a proximal end and with which the applicator can be secured to an X-ray irradiation device, and an inner recess which has an opening at the proximal end and into which an X-ray radiation source is insertable. The applicator has a solid porous structure on its outer surface which provides the air-permeable outer surface with a rigid shape. The solid porous structure forms a continuous air-permeable channel structure which is connected in an air-conducting manner to the proximal end of the applicator.

A method for treating a diseased site in a human or animal body is provided which includes injecting in a diseased site one or more phosphors which are capable of emitting ultraviolet or visible light into the body;

infusing the diseased site with a photoactivatable drug;

applying an initiation energy from an initiation energy source comprising an x-ray, gamma ray, or electron source to thereby initiate emission of ultraviolet or visible light into the body; and

controlling a dose of the initiation energy with a processor to produce (i) a cytotoxicity inside the diseased site of greater than 20% or (ii) a day-25 stable tumor volume,

wherein the processor is programmed to apply the initiation energy in a pulsed manner, wherein the initiation energy is delivered in either (i) a radiograph mode, or (ii) a pulsed fluoroscopy mode.

An x-ray micro-beam radiation production system is provided having: a source of accelerated electrons, an electron focusing component configured to focus the electrons provided by the source, and a target which produces x-rays when electrons impinge thereon from the source. The electron focusing component is configured to focus the electrons provided by the source such that they impinge at a focal spot having a width δ formed on a surface of the target. The focusing component is configured to move the electron beam relative to the target such that the focal spot moves across the target surface in the width direction, and/or the target is movable relative to the focusing component such that the focal spot moves across the target surface in the width direction, the surface velocity of the focal spot across the target surface in the width direction being greater than v.sub.t where: formula (I), k, ρ and c denoting respectively the heat conductivity, the density and the heat capacity of the target material, and d denoting the electron penetration depth in the target material. $\begin{array}{cc}{v}_t=\frac{\pi k}{4\rho c}.Math.\frac{\delta }{d^2},& \left(I\right)\end{array}$

Multimodal imaging apparatus and methods include a rotatable gantry system with multiple sources of radiation comprising different energy levels (for example, kV and MV). Fast slip-ring technology and helical scans allow data from multiple sources of radiation to be combined or utilized to generate improved images and workflows, including for IGRT. Features include large field-of-view (LFOV) MV imaging, kV region-of-interest (ROI) imaging, and scalable field-of-view (SFOV) dual energy imaging.

A radiotherapy delivery device is provided. The device includes a source of therapeutic radiation and a first detector positioned to receive radiation from the source of therapeutic radiation. The device also includes a source of imaging radiation and a second detector positioned to receive radiation from the source of imaging radiation. A collimator assembly is positioned relative to the second source of radiation to selectively control a shape of a radiation beam emitted by the second radiation source to selectively expose part or the whole of the second radiation detector. A reconstruction processor can be operatively coupled to the detector and configured to generate patient images based on radiation received by the second detector from the second source of radiation. The device is configured to move from one imaging geometry to another using all or part of the second detector.

The present disclosure lies in the field of medical radiotherapy and relates to an applicator for a medical radiotherapy device, an applicator system for a medical radiotherapy device and a method for using an applicator or an applicator system. The applicator includes an applicator head and an applicator body. The applicator head and the applicator body are embodied such that the applicator head can be assembled on, and disassembled from, the applicator body, in each case without damage.

A computer-implemented method of performing a treatment fraction of radiation therapy comprises: determining a current position of a target volume of patient anatomy; based on the current position of the target volume, computing an accumulated dose for non-target tissue proximate the target volume; determining that the accumulated dose is less than a current value for a dose budget of the non-target tissue; and in response to the accumulated dose being less than the current value for the dose budget, applying a treatment beam to the target volume while the target volume is in the current position.

Radiation therapy delivery system, including X-ray source, magnetic body rotation fixation node and/or mechanical body rotation fixation node; filter unit with a plurality of filters and a plug that circle a cylindrical element; drive unit for rotating filter unit; collimation elements in a collimation unit body, that includes collimation element fixation device and collimation photoelectric identification system; and processor controlling the filter unit to adjust X-ray filtration characteristics. The filter unit includes filter photoelectric identification system, controller, and photoelectric sensors. The cylindrical element includes slits located on rings that run along outer surface. Photoelectric sensors are triggered by a light beam that passes through the slits to identify/position filters. First ring with first photoelectric sensor identifies zero position of the filter, second ring with second photoelectric sensor identifies filter working positions, and third ring with a set of slits for each filter, and third photoelectric sensor for filter identification.

A computed tomography (CT) system and method is provided. The CT system is used to carry out an image improvement method in which a prior or previously-acquired patient image can be used to supplement or otherwise improve an acquired CT image, wherein the acquired projection data representative of the acquired CT image might be truncated or otherwise incomplete/insufficient to accurately and stably recover the scanned object/patient.

Systems and methods for the automatic generation and optimization of radiation therapy treatment plans, and systems and methods for the automatic generation and optimization of an adapted plan in an adaptive radiation therapy workflow.