A rotating shield brachytherapy (RSBT) apparatus includes a radiation source, at least one applicator, a catheter, a catheter drive assembly, a robotic positioning system, and a connection system. The applicator(s) is configured to be inserted or implanted into a patient. A distal end portion of the catheter has at least one radiation shield and is configured to receive a wire-mounted radiation source. The catheter drive assembly causes helical motion of the catheter and engages the proximal end portion of the catheter to selectively rotate the catheter about a longitudinal axis. The robotic positioning system aligns the catheter drive assembly, in both position and angular orientation at a modifiable rate, with the applicator(s), or to any programmed point in space. The connection system couples the catheter drive assembly to the applicator(s), and further decouple the catheter drive from the applicator(s). When the applicator(s) is coupled to the catheter drive assembly, the catheter can be advanced into, and out of, the at least one applicator at a variable rate through operation of the catheter drive a

Single-use brachytherapy systems for application of beta radiation to a target tissue, and methods of use. The single-use brachytherapy systems herein feature a cap into which a radionuclide brachytherapy source (RBS) can be inserted and a handle that removably attaches to the cap. When the handle is disengaged from the cap in order to access the RBS, the system is rendered useless for its original purpose, for its use as it was originally intended, for its use as prescribed, unless repaired.

Particle radiation therapy and planning utilizing magnetic resonance imaging (MRI) data. Radiation therapy prescription information and patient MRI data can be received and a radiation therapy treatment plan can be determined for use with a particle beam. The treatment plan can utilize the radiation therapy prescription information and the patient MRI data to account for interaction properties of soft tissues in the patient through which the particle beam passes. Patient MRI data may be received from a magnetic resonance imaging system integrated with the particle radiation therapy system. MRI data acquired during treatment may also be utilized to modify or optimize the particle radiation therapy treatment.

Provided herein are methods for decreasing the toxicity of advanced ablative cancer therapies on neighboring organs. The methods herein provide spacing between single or multiple tumor cites and immediate healthy organs while maintaining or increasing patient quality of life. Such toxicity isolation can be performed by inserting a spacer around the one or more tumor cites, which can be performed concurrently with fiducial marker placement.

Provided herein are fluoro-substituted porphyrin compounds, such as those having a structure represented by Formula (I), wherein R.sup.1 is a C1-C8 alkyl that is substituted with at least 1 fluorine (e.g., a C1-C8 alkyl substituted with 1-17 fluorine atoms); and X is an anion (e.g. a halogen ion (e.g., chloride, etc.), PF.sub.6, tosylate, besylate, and/or mesylate). Also provided herein are methods of making the fluoro-substituted porphyrin compounds, pharmaceutical formulations containing the same, and methods of use thereof.

The invention provides a device for the production, moderation and configuration of a neutron beam, comprising: an inlet opening (1) through which a proton beam is directed; a target (2) against which the proton beam is accelerated in order to generate neutrons; a moderator (3) to bring the neutrons to energies of the epithermal range; a reflective cover (4) surrounding the moderator (3); a filtration stage (5); an outlet opening (6) for the neutron beam, and a shield (7) to suppress the neutrons and gamma-radiation that do not exit the device via said outlet opening. The filtration stage (5) comprises at least three layers to filter respectively: rapid neutrons, thermal neutrons and gamma-radiation The invention is of use in neutron capture therapies, and more specifically, in boron therapies.

Provided is a radiation detection system for improving the accuracy of a neutron beam irradiation dose for a neutron capture therapy system. The neutron capture therapy system includes a charged particle beam, a charged particle beam inlet for passing the charged particle beam, a neutron generating unit for generating the neutron beam by means of a nuclear reaction with the charged particle beam, a beam shaping assembly for adjusting flux and quality of the neutron beam, and a beam outlet adjoining to the beam shaping assembly, the radiation detection system includes a radiation detection device arranged within the beam shaper or outside the beam shaping assembly, the radiation detection device is used for real-time detection of the overflowing neutron beam by the neutron generating unit or the generated γ-ray after the nuclear reaction of the charged particle beam with the neutron generating unit.

Embodiments of systems, devices, and methods relate to controlling beams for use in beam systems. An example method of controlling a travel path of a beam includes propagating a beam along a first path from an entry point of a dipole magnet through a non-gradient portion of the dipole magnet until the beam bends toward a first beam travel path of multiple beam travel paths of the dipole magnet. The example method further includes propagating the beam along the first beam travel path through a gradient portion of the dipole magnet to focus the beam for propagation to a downstream target. Embodiments further permit a compact beam system such that a series of magnets can be used to create a path that accommodates shielding to minimize the footprint of the beam system for facilities that may not otherwise support large systems due to space and safety constraints.

A source storing apparatus, source guiding system and source guiding method are provided. The source storing apparatus comprises: a source tank and a shielding plug, the source tank being provided with an opening and an accommodating cavity, the accommodating cavity being configured to accommodate a cobalt source box, the shielding plug being configured to seal an opening of the accommodating cavity; wherein a first connecting structure is provided on the cobalt source box; a second connecting structure is provided on an outer side of the shielding plug, a pickup structure is provided on an inner side of the shielding plug, and the first connecting structure is detachably connected to the pickup structure. The structure of the source storing apparatus is simplified; the installation and operation processes are simple with reduced operation requirements, and are time-consuming and labor-consuming. The cost of the source guiding apparatus is also greatly reduced.

A therapeutic applicator and method may include a wand portion and a module coupled to the wand portion. The module may have a body section and a recess positioned within the body section. The body section may include a prismatic member made of a transparent material and the body section may further include a convex surface. The convex surface may provide a magnification of a view that includes a region surrounding the recess. A radiation source may be positioned within the recess. The body section may have a thickness greater than a diameter of the radiation source which is sufficient to attenuate radiation being emitted from the radiation source while the transparent material of the body section allows visibility of a treatment site that is adjacent to the radiation source. The magnification of the view may fall in range between about 1.1 times to 50.0 times an unmagnified view.