Provided herein are fluoro-substituted porphyrin compounds, such as those having a structure represented by Formula (I), wherein R.sup.1 is a C1-C8 alkyl that is substituted with at least 1 fluorine (e.g., a C1-C8 alkyl substituted with 1-17 fluorine atoms); and X is an anion (e.g. a halogen ion (e.g., chloride, etc.), PF.sub.6, tosylate, besylate, and/or mesylate). Also provided herein are methods of making the fluoro-substituted porphyrin compounds, pharmaceutical formulations containing the same, and methods of use thereof.

An ion chamber has a chamber having an interior volume. There is a first electrode and a second electrode in the chamber and separated by a gap. A collector electrode is positioned between the first electrode and the second electrode. The collector electrode is shaped to occlude a portion of the first electrode from the second electrode.

A neutron capture therapy system and a target for a particle beam generating device, which may improve the heat dissipation performance of the target, reduce blistering and extend the service life of the target. The neutron capture therapy system includes a neutron generating device and a beam shaping assembly. The neutron generating device includes an accelerator and a target, and a charged particle beam generated by acceleration of the accelerator interacts with the target to generate a neutron beam. The target includes an acting layer, a backing layer and a heat dissipating layer, the acting layer interacts with the charged particle beam to generate the neutron beam, the base layer supports the action layer, and the heat dissipating layer includes a tubular member composed of tubes arranged side by side.

A patient positioning device has a robot arm and a patient receptacle held at the robot arm. The patient positioning device has a housing assembly for the robot arm. The housing assembly is provided with one or more housing units surrounding the robot arm at least partially. The one or more housing units are secured at the robot arm. The patient positioning device is provided with a shielding against ionizing radiation. At least one part of the shielding is arranged at the one or more housing units.

A cradle made of radiation-shielding material holds one or more radioactive seeds. The cradle surrounds all but a portion of the seed, and the potion of the cradle that does not surround the seeds creates an aperture through which the radiation escapes the cradle. The cradle reflects and absorbs radiation from the seed, resulting in directional dosing toward diseased tissue and away from healthy tissue. In a preferred embodiment the cradle has four walls and a bottom, forming a cavity into which the seed is secured with biocompatible epoxy. The side opposite the bottom is typically open, but may instead be made of a material that is transparent to radiation. The cradle wall thickness, bottom thickness, and cavity height determine the direction, shape, and intensity of the radiation dispersion. Cradles may be attached to a biocompatible mesh to form a sheet with directional radiation.

In general, radiation shielding systems that shield radiation from multiple directions are described. In one embodiment, a method of shielding radiation is provided, including supporting a shielding device on an object proximate a radiation source, positioning a first shielding portion in a vertical position relative to the object, positioning a second shielding portion to extend away from the first portion, the second shielding portion attached to the first portion, and shielding radiation from the radiation source by the first shielding portion and the second shielding portion such that the first and second shielding portions provide a radiation shielding zone for a healthcare practitioner.

Apparatus for shielding a non-human animal from a sterilizant. The apparatus (100, 200) defines a space (102, 202) for accommodating a non-human animal (111, 204) and a shield (107, 201) for shielding a part of the animal from a sterilizant such as radiation. Only exposing a specific part of the animal to sterilizant produces a sterile animal which is better adapted to mate with other animals When the sterilized animals are released in a sterile insect technique, the technique is more efficient because the released animals are better adapted to mate with a wild population.

Systems and methods monitoring progress of procedures by radiation exposure are provided. Position data is received for an equipment item used for the procedure and configured to produce radiation (“radiation device”). Position data is received from the tracking device during the procedure. An estimated exposure level is determined by a controller for the individual based, at least in part, on the position data from the tracking device relative to the position data from the radiation device and compared to a benchmark. If the estimated exposure level for the individual exceeds the benchmark, an electronic notification is generated.

An electron block frame pouring fixture, and a method of using the fixture, the fixture including a base member having a recessed portion surrounded on each side, the recessed portion configured to receive an electron block frame therein, and a plurality of clamp members connected to the base member proximate each of the respective sides of the recessed portion, the clamp members being configured to be selectively actuated to press a received electron block frame downward into the recessed portion, wherein the recessed portion is configured to prevent lateral movement of the received electron block frame.

Systems and methods for providing a real time visualization of scattered radiation in an operating room are provided. A number of visualization devices such as augmented reality (“AR”) tracking devices, electronic displays, or projection devices are in electronic communication with a controller and configured to display a visualization of scattered radiation. Position data is received from the position sensors associated with individuals in the operating room, the AR tracking devices, radiation producing medical equipment, or an operating table and the visualization is adjusted accordingly.