New techniques for remote administration of medicine and medical devices using an external guidance and activation system are provided. In some embodiments, medicine(s) and/or medical device(s) is/are energized to a predetermined threshold energy level by externally applied radiation, and then driven into the treatment target. The design of such device(s) (e.g., injectable machine(s)) may include sub-device(s), e.g., medical payload-carrying reservoir(s), injector(s) and abrasive tool(s), which may be activated magnetically and/or by such radiation. In some aspects, such sub-device(s) include actuable housing(s) and/or other sub-tool(s), delivering drugs to specific locations commanded by a control system or a user. In other aspects, a medicine and/or device is provided with multiple dipoles, each oriented differently in three-dimensional space, allowing a guidance control system, remote from the medicine or device, to drive the movement and three-dimensional orientation of the medical agent or particle according to a three-dimensional path.

Provided herein is a neoadjuvant therapy and/or adjuvant therapy for the treatment of uveal melanoma, inter alia, ocular tumors in uveal melanoma to reduce the incidence of metastasis and/or enucleation and/or preserving eye function.

The present disclosure relates to a tissue isolation device capable of repeated inflation and deflation in vivo. The device includes: an isolation balloon arranged between healthy tissues and target tissues for a radiotherapy course, and the isolation balloon is removed from a body of a subject following the radiotherapy course. The isolation balloon is operable to assume an inflated state and a deflated state, the isolation balloon in the inflated state is used to isolate the healthy tissues and the target tissues. The isolation balloon includes a first contact surface and a second contact surface, under the inflated state, the first contact surface contacts the healthy tissues, and the second contact surface contacts the target tissues, a distance between the first contact surface and the second contact surface is in a preset range.

An unlocking assembly includes a fixing plate, locking bodies, and a flexible member. The fixing plate is provided with fixing holes; the locking bodies are movably mounted in the fixing holes; the flexible member is connected to the locking bodies and is configured to drive the locking bodies to move towards a direction extending out of the fixing holes.