Embodiments of the invention provide a method and system that allows parameters of a desired target image to be determined from hyperspectral imagery of scene. The parameters may be representative of various aspects of the scene being imaged, particularly representative of physical properties of the scene. For example, in some medical imaging contexts, the property being imaged may be blood perfusion or oxygenation saturation level information per pixel. In one embodiment the parameters are obtained by collecting lower temporal and spatial resolution hyperspectral imagery, and then building a virtual hypercube of the information having a higher spatial resolution using a spatiospectral aware demosaicking process, the virtual hypercube then being used for estimation of the desired parameters at the higher spatial resolution. Alternatively, in another embodiment, instead of building the virtual hypercube and then performing the estimation, a joint demosaicking and parameter estimation operation is performed to obtain the parameters. Various white level and spectral calibration operations may also be performed to improve the results obtained. While establishing functional and technical requirements of an intraoperative system for surgery, we present iHSI system embodiments that allows for real-time wide-field HSI and responsive surgical guidance in a highly constrained operating theatre. Two exemplar embodiments exploiting state-of-the-art industrial HSI cameras, respectively using linescan and snapshot imaging technology, were investigated by performing assessments against established design criteria and ex vivo tissue experiments. We further report the use of one real-time iHSI embodiment during an ethically-approved in-patient clinical feasibility case study as part of a spinal fusion surgery therefore successfully validating our assumptions that our invention can be seamlessly integrated into the operating theatre without interrupting the surgical workflow.

Improved fluoresced imaging (FI) endoscope devices and systems are provided to enhance use of endoscopes with FI and visible light capabilities. An endoscope device is provided for endoscopy imaging in a white light and a fluoresced light mode. A relay system includes an opposing pair of rod lens assemblies positioned symmetrically with respect to a central airspace. The rod lens assemblies include a meniscus lens positioned immediately adjacent to a central airspace and with the convex surface facing the airspace, a first lens having positive power with a convex face positioned adjacent to the inner face of the meniscus lens, a rod lens adjacent to the first lens having positive power and an outer optical manipulating structure selected from various designs providing chromatic aberration correction.

A medical observation system includes: a light source configured to emit, to body tissue, at least one of first narrow band light and second narrow band light; an imaging element that includes: a pixel portion including plural pixels arranged in a two-dimensional matrix; and a color filter including red filters, green filters, and blue filters that are provided on light receiving surfaces of the plural pixels, each of the light receiving surfaces including any one filter of the red, green, and blue filters on each of the light receiving surfaces; and a cut filter that is provided on a light receiving surface side of at least the pixels provided with the green filters, the cut filter being configured to shield light of a shorter wavelength band including the wavelength band of the second narrow band light, and transmit therethrough the first narrow band light.

A medical image processing device includes a processor configured to: obtain image data; generate, based on the obtained image data, a captured image including color component signals including a red component signal representing a red component, a green component signal representing a green component, and a blue component signal representing a blue component; calculate an intensity ratio between a fluorescent component signal and a reflected light component signal in a pixel of the captured image; determine, based on the calculated intensity ratio in the pixel of the captured image, a fluorescence region and a background region in the captured image; and generate a fluorescence image by performing, based on a result of the determination, image processing with parameters different from each other for color component signals in pixels positioned in the fluorescence region and color component signals in pixels positioned in the background region.

A processing system includes a processor with hardware. The processor is configured to perform processing of acquiring a detection target image captured by an endoscope apparatus, controlling the endoscope apparatus based on control information, detecting a region of interest included in the detection target image based on the detection target image for calculating estimated probability information representing a probability of the detected region of interest, identifying the control information for improving the estimated probability information related to the region of interest within the detection target image based on the detection target image, and controlling the endoscope apparatus based on the identified control information.

An imaging device includes a voltage generation circuit and an output circuit. The voltage generation circuit includes a first capacitance element including a fifth terminal. The voltage generation circuit is configured to provide the fifth terminal with a first voltage in accordance with a power source voltage so as to store an electric charge in the first capacitance element. The voltage generation circuit is configured to increase a voltage of the fifth terminal by a second voltage in accordance with the power source voltage so as to generate a control voltage having a greater absolute value than an absolute value of the power source voltage. The output circuit is configured to output the control voltage to at least one of a gate terminal of a reset transistor of a pixel and a gate terminal of a transfer transistor of the pixel.

A switch unit includes: a tactile switch; a cable which transmits an operation signal generated when the tactile switch is operated; a formed part where a fitting engagement portion which is disposed on an operation section exterior member at a predetermined position, a recessed surface which is formed on a side of a first end portion with respect to the fitting engagement portion and where the tactile switch is mounted, a cable fixing portion which is disposed on a side of a second end portion which is a side opposite to the first end portion with the fitting engagement portion positioned between the first end portion and the second end portion and to which the cable is connected, and a circuit which electrically connects the recessed surface and the cable fixing portion to each other and transmits an operation signal generated by the tactile switch to the cable are formed.

A wireless camera system includes a wireless camera for use in endoscopic procedures. The wireless camera can releasably couple with an endoscope (e.g., with a cordless disposable endoscope). The wireless camera can wirelessly transmit data to a controller, which can provide data output (e.g., snapshot images, video recording captured by the wireless camera) to an electronic display and to one or more data outputs (e.g., USB drive or other portable memory stick, to a remote computer or computer network, hard disk, compact flash drive, email, etc.).

A device includes an offset subtraction unit; an image sensor which receives, for each of a plurality of bright frames, a respective image signal obtained during a respective exposure time of the image sensor, and transmits the same to the offset subtraction unit, and receives, for a dark frame, a respective image signal obtained during a respective exposure time of the image sensor, and transmits the same to the offset subtraction unit; and a control unit which ensures that the image sensor alternately transmits a number of bright frames and one dark frame to the offset subtraction unit. An amount of light by which the respective image signal for each of the bright frames is generated is larger than an amount of light by which the respective image signal for the dark frame is generated; and the offset subtraction unit obtains an offset and subtracts the offset from a signal.

Disclosed is a method for operating an endoscope system and an endoscope system comprising an image sensor and a processing device, the image sensor comprising an image sensor output, the processing device comprising an input connected to the image sensor output. The method comprising: consecutively receiving frames captured by the image sensor; receiving a first capture signal, indicative of an operator performing a first action associated with capturing a still image of the frames captured by the image sensor; storing a first plurality of frames of the frames captured by the image sensor; determining one or more quality properties of each of the first plurality of frames; and selecting a designated frame of the first plurality of frames based on the one or more quality properties.