The invention comprises a multi-axis charged particle irradiation method and apparatus. The multi-axis controls includes separate or independent control of one or more of horizontal position, vertical position, energy control, and intensity control of the charged particle irradiation beam. Optionally, the charged particle beam is additionally controlled in terms of timing. Timing is coordinated with patient respiration and/or patient rotational positioning. Combined, the system allows multi-axis and multi-field charged particle irradiation of tumors yielding precise and accurate irradiation dosages to a tumor with distribution of harmful proximal distal energy about the tumor.

Provided is a technique by which each nuclide is optimized in terms of energy and number of particles and pre-accelerated so as to be injected into a main accelerator in charged particle beam irradiation by the combined use of different nuclides. A charged particle beam injector includes: a first ion source that generates first nuclide ions; a first linear accelerator that linearly accelerates the generated first nuclide ions to form a first charged particle beam; a second ion source that generates second nuclide ions; a second linear accelerator that linearly accelerates the generated second nuclide ions to form a second charged particle beam; and a switching electromagnet that injects one of the first charged particle beam and the second charged particle beam into an inflector of a main accelerator.