An irradiator includes: a first electrode to which a voltage is applied for generating a plasma; and a holding member holding the first electrode; wherein: the holding member has a first member and a second member that are in contact with each other to constitute an accommodation space accommodating the first electrode; and a contact surface between the first member and the second member includes a non-perpendicular contact surface that is non-perpendicular to an axis of the first electrode.

An irradiator includes: a piezoelectric transformer accommodated in a housing; a first electrode connected to the piezoelectric transformer, to which a voltage is applied from the piezoelectric transformer; and an irradiation opening that ejects at least one of a plasma generated by the first electrode and an active gas generated by the plasma. At least a part of the first electrode is located between the piezoelectric transformer and the irradiation opening.

A system for generating cold plasma is presented, suitable for use in in-vivo treatment of biological tissue. The system comprising: a control unit connectable to an elongated member at a first proximal end of the elongated member. The elongated member comprises a plasma generating unit at a second distal end thereof and gas and electricity transmission channels extending from said first proximal end towards said plasma generating unit. The control unit comprises a gas supply unit configured to provide predetermined flow rate of selected gas composition through said gas transmission channel and a power supply unit configured to generate selected sequence of high-frequency electrical pulses, typically in mega Hertz range, directed through said electricity transmission channel, thereby providing power and gas of said selected composition to the plasma generating unit for generating cold plasma.

A system including an internal cold plasma system, including an internal cold plasma applicator configured to couple to a surface surrounding a cavity and to produce a cold plasma between the internal cold plasma applicator and the surface.

Provided herein is an integrated target structure for generating charged particles. The integrated target structure according to an embodiment of the present disclosure includes a target layer emitting charged particles depending on an irradiation of a laser beam, an optical component controlling at least one of the laser beam and the charged particles, and a support body supporting the target layer and the optical component using one structure.

Apparatuses and methods for delivering bioactive substances or cosmetic substances using plasmaporation and microneedles are provided. The delivery of the substances includes topical, intracellular, intercellular, and transdermal delivery to the subject.

Provided are methods of immunizing a viewport of a medical device against fogging before or during a medical procedure, and related apparatuses and devices. The methods comprise applying plasma to the viewport prior to use, thereby rendering a surface of the viewport highly hydrophilic. The methods eliminate or at least significantly reduce blur due to fogging.

A plasma irradiation apparatus includes: a gas guide channel defining therein a flow path for flow of a discharge gas, with an outlet port formed at an end of the flow path; and a discharge section that generates plasma discharge in the gas guide channel. The plasma irradiation apparatus is mounted to a distal device which is movable relative to a target substance. The plasma irradiation apparatus further includes a valve arranged in the gas guide channel or a gas supply channel and configured as a valve capable of changing a flow rate of the discharge gas according to an opening degree of the valve or as a check valve.

Medical devices for generating an aerosol and plasma, e.g., for therapeutic treatment are described. The medical device may include a nebulizer, the nebulizer including an outer compartment, an inner compartment, and a needle radially inward of the inner and outer compartments. The medical device may include at least one electrode and a chamber, wherein a distal-facing surface of the chamber defines at least one plasma outlet and a nozzle in communication with the nebulizer, an end of the electrode being proximate the plasma outlet.

This disclosure relates to stabilized anti-cancer atmospheric plasma (CAP)-stimulated media, to methods for preparing such media, and to methods of treatment using such media.