A single non-thermal atmospheric plasma generation device is used to detect and analyze vital fields of a living subject to determine the presence of a condition, such as an illness or injury, and responsively modify characteristics of the plasma to treat, heal, or alleviate the condition. The device includes a capacitance dielectric discharge array of plasma emitters, and a controller having a power supply, a transformer, and circuit components for driving the transformer at a resonant frequency of the plasma emitters to cause the plurality of plasma emitters to ionize surrounding air and produce the non-thermal plasma. The resonant frequency is around 60 GHz and harmonics thereof. A receiver of the device recovers frequency mixing products from the plasma, which are extracted by signal processing circuitry; signals in the VHF and UHF bands are extracted and analyzed to determine whether signatures of particular vital fields are present.

An integrated gas-enhanced electrosurgical generator. The generator comprises a high frequency power module, a low frequency power module and a gas module. The high frequency power module adapted to generate an electrical energy having a band of frequencies centered around a first frequency, wherein the electrical energy has a first power as the first frequency and a second power lower than the first power at a second frequency lower than the first frequency. The low frequency power module having an input connected to an output of the high frequency module. The low frequency module comprises a resonant transformer comprising a ferrite core, a primary coil and a secondary coil, the secondary coil having a larger number of turns than the primary coil, wherein the resonant transformer has a resonant frequency equal to the second frequency. The gas module is adapted to control a flow of an inert gas.

Applications of dielectric barrier discharge (DBD) based atmospheric pressure plasma jets are often limited by the relatively small area of treatment due to their 1D configuration. This system generates 2D plasma jets permitting fast treatment of larger targets. DBD evolution starts with formation of transient anode glow, and continues with development of cathode-directed streamers. The anode glow can propagate as an ionization wave along the dielectric surface through and outside of the discharge gap. Plasma propagation is not limited to 1D geometry such as tubes, and can be organized in a form of a rectangular plasma jet, or other 2D or 3D shapes. Also described are a method for generating 2D plasma jets and use of the 2D plasma jets for cancer therapy.

An apparatus or device for performing cold atmospheric plasma procedures. The device or apparatus has a housing, a chamber within the housing, an entry port to the chamber, a plurality of exit ports from the chamber, and a plurality of electrodes mounted in the housing, each of the plurality of electrodes having a distal end adjacent one of the plurality of exit ports. The entry port, chamber, exit ports and plurality of electrodes are configured to provide for an inert gas flowing in the entry port and through the chamber to the exit port to become plasmatized by electrical energy applied to the plurality of electrodes to form a cold plasma flowing from the exit ports

A plasma system is disclosed. The plasma system includes a plasma instrument having an elongated body defining a lumen therethrough and a first electrode and a second electrode; an ionizable media source in fluid communication with the lumen and configured to supply ionizable media thereto; and a variable frequency energy source adapted to be coupled to the first and second electrodes and configured to supply energy to the first and second electrodes sufficient to ignite ionizable media supplied by the ionizable media source to generate a plasma influent, wherein a frequency of the energy is adjustable to modify at least one property of the plasma effluent.

A plasma treatment unit having a high-voltage stage (5, 6), arranged in a housing, for generating high-voltage signals suitable for the generation of a plasma, and having a head part (2) which is connectable to the high-voltage stage (5, 6) and in which there is situated an electrode arrangement (13) shielded by a dielectric (9), is suitable for plasma treatments in particular in the body interior by virtue of the fact that the head part (2) has an elongate transition piece (10) which is attachable to the housing and on that end of which which is not connectable to the housing there is arranged a treatment head (16, 16), the dimensions of which perpendicular to the longitudinal direction of the transition piece (10) greatly exceed the dimensions of the transition piece (10), and that, in the treatment head (16, 16), the electrode arrangement (13) forms a spatially closed flexible sheath (12) around a resiliently elastic core (14) and is covered at its outer lateral surface by a thin layer (15) of the flexible dielectric (9), such that the treatment head (16, 16) can, as it is inserted into a body interior, assume the shape of the surrounding tissue in the body interior.

Power circuitry for cold plasma generation; optionally plasma for therapeutic use. Cold plasma generation occurs at the distal end of a catheter-like device which is flexible, narrow (e.g., less than 5 mm in diameter), and longitudinally extended to reach, e.g., 50-100 cm into body cavities. A cable used for power transmission is a part of the power generating circuit, its intrinsic impedance being a major contributor to and constraint on the time constant of an entraining RC circuit whose resonant frequency entrains the frequency of power generation. In some embodiments, inductive transformer coupling to the entraining/transmission line circuit is used to generate voltage gain. In some embodiments, transformer coupling is divided into a plurality of stages. This potentially enables practically achieving high transmission frequencies with higher gain, lowered sensitivity to variability in distal portions of the entraining RC circuit, and/or longer transmission lines compared to a single-stage transformer configuration.

A plasma irradiation device has a gas flow channel and an electric field generation section and is provided in a handpiece. The gas flow channel is a flow channel for supplying a gas from the outside of the handpiece to a distal end portion of the acting member. The electric field generation section has a first electrode portion, a second electrode portion, and a dielectric member and is disposed in the gas flow channel. The electric field generation section generates an electric field in a space within the gas flow channel by using a potential difference between the first electrode portion and the second electrode portion, thereby producing low-temperature plasma discharge.

A system and method for using a concomitant effect of cold atmospheric plasma and Trastuzumab to overcome Trastuzumab invalidity or resistance and enhances the outcome of breast cancer therapy in both HER2-positive and negative cancer cells.

A cold plasma accessory having a hand piece having within in it flexible tubing, wiring, a PCB board connected to the wiring, and a conductive connector tube electrically connected to the PCB board, the conductive connector tube having an inner channel, a rigid tube extending from the distal end of the hand piece, and an electrode within the rigid tube. The electrode comprises a conductive connector having a contact surface contacting the conductive connector tube, a distal end surface facing away from the conductive connector tube, and a channel extending through a center of the conductive connector, the channel being fluidly connected to the flexible tubing, the distal end surface of the conductive connector being outside of the channel in the conductive connector, and a conductive wire connected to the distal end surface of the conductive connector.