Magnetic beads comprise a plurality of magnetic nanoparticles, dispersed in a non-magnetic matrix. The magnetic beads have an average particle size of 0.1 μm to 100 μm. The matrix may comprise an inorganic metal oxide or a polymer. The magnetic beads have a specific surface area of at least 40 m.sup.2/g.

Provided is the use of a magnetic nanocomposite material that is capable of polymerising an anaerobic adhesive or other monomeric materials in need thereof as a nanoinitiator, in said polymerisation. Also disclosed herein is a method of manufacturing the magnetic nanocomposite material. In a preferred embodiment, the nanoinitiator is a magnetic nanoparticle core covered with a shell bearing dendrons that chelate an initiating metal ion of copper.

A method for producing crystalline α-Fe2O3 nanoparticles involving ultrasonic treatment of a solution of an iron (III)-containing precursor and an extract from the seeds of a plant in the family Linaceae. The method involves preparing an aqueous extract from the seeds of a plant in the family Linaceae and dropwise addition of the extract to the solution of an iron (III)-containing precursor. The method yields crystalline nanoparticles of α-Fe.sub.2O.sub.3 having a spherical morphology with a diameter of 100 nm to 300 nm, a mean surface area of 240 to 250 m.sup.2/g, and a type-II nitrogen adsorption-desorption BET isotherm with a H3 hysteresis loop. A method for the photocatalytic decomposition of organic pollutants using the nanoparticles is disclosed. An antibacterial composition containing the crystalline α-Fe.sub.2O.sub.3 nanoparticles is also disclosed.

The present invention relates to a method for reducing or preventing the formation or activity of a corrosion-associated biofilm on a metal surface, wherein the method comprises contacting the metal surface with a liquid composition comprising biocidal preparation. The present invention also relates to a microbicidal composition comprising at least one alcohol, one liquid hydrocarbon, a bacteriophage immobilized on a magnetic nanocomposite, at least one phage releasing reagent and one stabilizer. The microbicide composition and method of the present invention reduces biofilms on surfaces, and consequently, reduces, mitigates, or eliminates MIC in internal surface of the oil transporting pipelines.

A non-invasive drug release monitoring and quantification method and system is provided using magnetic particle imaging to monitor in vivo drug release. A living body is imaged with a magnetic particle imager after the living body has been injected with a nanocomposite composed of a biodegradable polymer shell layer containing a cluster of magnetic nanoparticles and a drug. A magnetic particle signal is detected and obtained which represents the release of magnetic nanoparticles from the PLGA shell layer, which is the result of a disassembly of the biodegradable polymer shell layer due to biological degradation of the biodegradable polymer shell layer in an acidic environment of the living body resulting in drug release and magnetic nanoparticle release. The release of the drug in the living body is quantified using a previously obtained reference linear relationship defined between the magnetic particle signal and the drug release rate.

Methods are disclosed for displaying a health status on a user-worn or carried device comprising of disposing a magnet within a housing of the user-worn or carried device, configured to detect a magnetic field supercutaneously, wherein the field is generated by an interaction of the magnet with magnetic nanoparticles of a delivery agent delivering a therapeutic or vaccine intravenously, converting the detected magnetic field into a field-specific electrical signal and outputting at least one of a pre-defined color, symbol, or audio-coded display on a display portion of the user-worn or carried device signaling the user health status based on the converted field-specific electrical signal.

The present invention provides a method for preparing iron oxide magnetic particles and iron oxide magnetic particles prepared thereby, wherein the method includes (a) synthesizing a complex by reacting iron and one or more compounds selected from the group consisting of an aliphatic hydrocarbonate having 4 to 25 carbon atoms and an amine compound, (b) synthesizing an iron oxide crystal nucleus by mixing the complex with a mixture of an unsaturated aliphatic hydrocarbon-based compound having 4 to 25 carbon atoms and an ether-based compound, and (c) forming a shell by mixing the iron oxide crystal nucleus and an MXn compound with a mixture of an unsaturated aliphatic hydrocarbon-based compound having 4 to 25 carbon atoms and an ether-based compound, wherein M is a heavy atom element, X is a halogen element, and n is an integer of 1 to 6.

A nanoagent for detections and treatments of multiple targets of interest includes multiple types of nanocomposites, each type of nanocomposites comprising at least one nanostructure, each nanostructure having a core and a shell surrounding the core; a respective reporter assembled on the shell of each nanostructure; and a layer of a respective treating agent and a respective targeting agent conjugated to the respective reporter. In use, each type of nanocomposite targets to a respective target of interest according to the respective targeting agent and releases the respective treating agent and the nanostructure therein for therapeutic treatment of the respective target of interest, and the respective target of interest transmits at least one signature responsive to the respective reporter for detection of the respective target of interest.

A metal atom cluster-embedded magnetic iron oxide nanoparticle (MION) is disclosed. The metal atom cluster is embedded in an iron oxide crystal matrix and has a content of 0.1% to 15%. A method for preparing the MION includes: dissolving a metal precursor of iron oxide, an organic acid, and an organic amine in an organic solvent to form a uniform reaction system; heating the reaction system to 150° C. to 350° C. in an inert gas atmosphere; adding a metal atom cluster precursor; and heating to perform a reflux reaction until the metal atom cluster precursor is completely decomposed. The MION shows improved magnetic properties due to the embedding of the metal atom cluster, and the iron oxide fully ensures the stability of properties of the nanoparticles. The nanoparticles are especially applicable to biomedical detection and therapy and other fields.

The present invention provides iron oxide magnetic particles including an iron oxide and MX.sub.n, wherein M includes one or more selected from the group consisting of Cu, Sn, Pb, Mn, Ir, Pt, Rh, Re, Ag, Au, Pd, and Os, X includes one or more selected from the group consisting of F, Cl, Br, and I, and n is an integer of 1 to 6.