A system for carrying out gas chromatography/mass spectroscopy (GC/MS) on gasses trapped in glass solidified from molten glass includes a glass sample vacuum chamber having a gas inlet, a gas outlet, and an introduction port for receiving the glass sample; a crushing tool for crushing the glass sample; a gas sample vacuum chamber disposed in downstream fluid communication with the glass sample vacuum chamber; a supply of carrier gas in fluid communication with the glass sample vacuum chamber; a GC/MS analyzer in downstream fluid communication with the gas sample vacuum chamber; an injector in fluid communication between the GC/MS analyzer and the gas sample vacuum chamber and for injecting the gas sample into the GC/MS analyzer; a gather valve in fluid communication between the glass and gas sample vacuum chambers; and a booster in fluid communication with the gas sample vacuum chamber.

A mass spectrometer provided with an ionization chamber (10) in which ionization is performed on a sample by laser ionization, includes an opening part (12) that is provided on a side wall of the ionization chamber (10), and includes a door (13); a ventilation port (14) provided in a wall of the ionization chamber (10), which is opposite to the opening port (12); and a gas supplier (64), (67) for supplying high-pressure cleaning gas to the ionization chamber (10) through the ventilation port (14). In this configuration, the high-pressure cleaning gas flows into the ionization chamber (10) from the gas supplier (64), (67) while the door (13) is opened, thereby blowing up particles including fragments of bacterial cells, which are piled up on a floor of the ionization chamber (10), and/or sweeping particles floating near the floor, so as to discharge the particles to the outside.

A GC/MS arrangement, comprising: a GC unit; an MS unit; a transfer line fluidly connecting the GC unit and the MS unit a carrier gas valve for selectively supplying carrier gas to the transfer line; at least one monitoring unit associated with the MS unit for monitoring at least one operational condition of the MS unit; and a controller connected to the at least one monitoring unit and carrier gas valve, configured to close the carrier gas valve when a predetermined operational event is detected by the at least one monitoring unit.

Provided is a valve 130 which requires only a small space for the open/close operation of an opening 113 in a partition wall. A sealing part 140 includes a sealing member 141 for sealing the opening by being pressed onto the partition wall around the opening. An urging means 144 urges the sealing member 141 against the opening when the sealing member 141 is in contact with the opening. A driving means 160 generates a driving force orthogonal to an opening central axis A which is an axis perpendicular to a partition plate 111 and passing through the center of the opening. A linkage 150, which is a Scott Russell linkage connecting the sealing part 140 and the driving means 160, converts the driving force of the driving means 160 into a driving force which is parallel to the opening central axis A and makes the sealing part 140 move along the same axis.

A cleanliness monitor, an evaluation system and a method. The cleanliness monitor may include: a first vacuum chamber, a second vacuum chamber, a molecule collector, a release unit, a mass spectrometer, a manipulator that may be configured to move the molecule collector from the first position to the second position, and an analyzer. The mass spectrometer may have a line of sight to an inner space of the second vacuum chamber. The mass spectrometer may be configured to monitor the inner space of the second vacuum chamber and to generate detection signals that are indicative of a content of the inner space of the second vacuum chamber. A first subset of the detection signals may be indicative of a presence of the at least subset of released organic molecules. The analyzer may be configured to determine, based on the detection signals, the cleanliness of at least one out of (a) the first vacuum chamber, and (b) a tested vacuum chamber. The tested vacuum chamber is fluidly coupled to the first vacuum chamber.

A mass spectrometer vacuum interface can include a skimmer apparatus having a skimmer aperture and an internal surface. A method of operating the mass spectrometer vacuum interface can include establishing an outwardly directed flow along the internal surface of the skimmer apparatus.

Certain embodiments described herein are directed to methods of using couplers to provide a seal between a source assembly and a vacuum chamber. In certain examples, the source assembly can be inserted into a vacuum chamber. In some examples, the source assembly can be sealed to the vacuum chamber by rotation of a moveable component in a first direction to provide an axial force to seal the source assembly to the vacuum chamber. Rotation of the moveable component in a second direction can release the provided axial force to permit removal of the source assembly from the vacuum chamber.

The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used. In various operational modes of the IMS-MS device, mobility-separated ions are allowed to pass through an ion gate and the vacuum inlet for mass analysis.

A system for analyzing an analyte is described herein. The system includes a chamber having an inlet and a semi-permeable membrane arranged to seal the inlet. The semi-permeable membrane includes a cross-linked mixture of a first compound and a second compound. The system can also include a radiation source arranged in the vacuum chamber, the radiation source spaced apart from the semi-permeable membrane and adapted to irradiate the semi-permeable membrane with electromagnetic radiation at a frequency at least partially absorbed by the semi-permeable membrane.

Provided is an ion analyzer characterized by: an ionization chamber (10) to be maintained at atmospheric pressure; an analysis chamber (11) for analyzing an ion generated in the ionization chamber (10); a vacuum pump (15, 16) for evacuating the inside of the analysis chamber (11); a capillary (102) for allowing the ionization chamber (10) and the analysis chamber (11) to communicate with each other; a conductance changer (103, 104) for changing the conductance of the capillary (102); and a controller (20) for operating the conductance changer (103, 104) in such a manner as to decrease the conductance of the capillary (102) when the degree of vacuum in the analysis chamber (11) is lower than a predetermined degree of vacuum.