A detachable and foldable game board includes a board and a box. A plurality of creases is provided and spaced equidistantly on the board along a transverse direction thereof. Two ends of the board are respectively provided with a left side strip and a right side strip which are separated by the creases. The left side strip, the board and the right side strip are foldable along the creases. The right side strip is detachably connected to the box by a connection mechanism. A top portion of the box is recessed to form a certain number of accommodating cavities, and there is at least one accommodating cavity. The board can be folded and an elastic tightening band is used to tightly wrap the board and the box together. The overall size is greatly reduced and it is convenient to carry.