A process for making and using a tissue preservation gel. The gel is comprised of water, reticulated acrylic acid, water soluble short-chain paraben, isopropyl alcohol and either triethanolamine or propylene glycol. To use the gel, a tissue to be preserved is first bathed in hypertonic sodium chloride, then soaked in a wash in multiple increasing concentrations of isopropyl alcohol and then preserved indefinitely in the tissue preservation gel.

Methods and compositions for the prevention or reduction of platelet transfusion associated complications are provided. The subject methods include modifying donor whole blood or platelets prior to transfusion to prevent or reduce alloimmune platelet refractoriness.

Disclosed are compounds and compositions for slowing, preventing, or reversing platelet damage, particularly as may occur during blood banking or during refrigeration of platelets. Also disclosed herein are methods for storing platelets and methods for improving platelet survival upon transfusion with one or more compounds or compositions as described herein.

The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.

The present disclosure provides a liquid-based cell preservation solution and a method for preparing the same. The preservation solution includes, by mass percentage: 15 to 20% of an alcohol, 0.4 to 0.7% of a buffer component, 0.2 to 0.5% of an ionic strength modifying agent, 0.05 to 2% of an anticoagulant, 0.05 to 0.2% of a mucus dissociating agent, 0.5 to 0.9% of a preservative, and purified water as the balance. The components of cell preservation solution are set reasonably, and the cells may be preserved at normal temperature for a long time to maintain the cell morphology. Addition of the mucus dissociating agent may effectively soften cell mucus, and separates cells adhered by mucus in the sample, thereby preventing cell accumulation. Addition of the preservative may effectively inhibit the proliferation of mold, bacteria or other pathogens and facilitate cell preservation.

Described herein are methods for inactivation or reduction of pathogens, microorganisms or parasites in a sample, media, composition, utility, device, surface or organism by treatment with an alkylating compound of Structure I, followed by elimination or reduction of the residual compound of Structure I by treatment with a neutralizing agent, which eliminates or reduces the toxicity or other undesirable properties of the alkylating compound having Structure I. The neutralizing agent can be present in a treatment solution or be part of a solid-phase agent, and acts by eliminating the alkylating properties of the alkylating compound of Structure I.

The present disclosure provides a method for inhibiting cytomegalovirus (CMV) replication in a cell infected with CMV, the method comprising contacting the cell with a bisbenzimidazole compound. The present disclosure provides a method of treating a CMV infection in an individual, the method comprising administering to the individual an effective amount of a bisbenzimidazole compound.

A method for preserving a tissue graft includes submerging the tissue graft in a solution containing one or more antimicrobial and/or stabilizing agents and storing the tissue graft in the solution for a period of time of at least 24 hours while the solution is in an unfrozen state. A tissue preservation system includes a solution containing one or more antimicrobial and/or stabilizing agents and a tissue graft in the solution.

A repaired ex vivo organ suitable for transplantation in a human, said repaired ex vivo organ having undergone ex vivo organ perfusion for a maintenance period, wherein said organ had been assessed as being unsuitable for transplantation into a human before the maintenance period and was determined to be suitable for transplantation after the maintenance period.

A sperm wash device for collecting motile sperm includes a first chamber section for holding an unwashed semen sample, a second chamber section for holding sperm wash media disposed over and attached to the first chamber section, and a ledge separating the first chamber section from the second chamber section. The ledge includes a slot therein that is configured be filled with sperm wash media that does not get recovered. A slider is placed on the ledge. Characteristically, the slider is moveable between a first position and a second position. At the first position, the slider allows fluid communication between the first chamber section and the second chamber section. At the second position, the slider blocks fluid communication between the first chamber section and the second chamber section. A method of using the sperm wash device is also provided.