The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend a sample in preservation fluid and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature.

A system and method for tissue perfusion to assess, maintain, mature, and possibly rehabilitate the tissue. The system of the present teachings includes a tissue enclosure having a fluid reservoir. Pumps, valves, and a controller move perfusate through the tissue. The system includes features to assist in monitoring the health of the tissue, and a removable tray to facilitate moving the tissue from a point of origin to the tissue enclosure. The system moves perfusate to and through the tissue, and provides nutrition to the tissue. The system includes an output flow rate/volume sensor, at least one infusion pump, disposable and durable parts, and a sensor suite.

Systems and methods for providing secure, sterile, and temperature-controlled environment for transporting biological samples and further providing active tracking allowing a medical team, or any other interested party, to know the geographic location and condition of the biological sample, as well as the state of the consumables.

The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.

A multi-organ repairing and transferring device without interrupting a blood flow includes a first perfusion bin, a second perfusion bin and a third perfusion bin which are configured for storing respective organs. A first pump is arranged on a first pipeline, two ends of the first pipeline are connected with the first perfusion bin and the second perfusion bin respectively, a second pump is arranged on a second pipeline, two ends of the second pipeline are connected with the first perfusion bin and the second perfusion bin respectively, a third pump is arranged on a third pipeline, two ends of the third pipeline are connected with the first perfusion bin and the third perfusion bin respectively, and a fourth pump is arranged on a fourth pipeline, two ends of the fourth pipeline are connected with the first perfusion bin and the third perfusion bin respectively.

A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.

The present disclosure relates to devices and methods for increasing the probability of a successful organ donation by decreasing organs' warm ischemia time. Furthermore, the present disclosure relates to increasing the pool of eligible donors, including donors who had prior chest surgeries or prior abdominal surgeries. The present disclosure provides a catheter extending through a cannula, wherein the cannula delivers cold perfusion fluid and the catheter blocks the aorta, forcing the cold perfusion fluid to pass to organs in the donor's abdomen. The present disclosure further provides for advancing the catheter from a retracted position to an extended position, and creating a watertight seal at the cannula to prevent backflow of cold perfusion fluid.

A dynamic temperature regulating device is for use in association with a temperature-controlled container. The dynamic temperature regulating device includes at least one heat source, at least one heat sink, a heat transfer medium and a control system. At least one of the heat source and the heat sink is a PCM (phase change material). The heat transfer medium is in thermal communication with and operably connected to the at least one heat source and the at least one heat sink. The control system is for controlling the selective thermal communication with the at least one heat source and with the at least one heat sink to regulate the temperature of the temperature-controlled container. A detachable PCM contained volumes includes a sealed housing, a phase change material and a heat transfer medium and functions as a PCM thermal energy storage volume.

The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.