A system configured to support growth and development of a premature fetus is disclosed. Specifically, a method and apparatus configured to provide extracorporeal support for premature fetuses is disclosed.

The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.

Disclosed is a device for the perfusion of an organ, including: a container of fluid, containing an organ bathed in the perfusion fluid; a first path including an inlet, an outlet and a pump; and a second path including an inlet, an outlet and a pump. The “arterial” outlet of the first path has a diameter smaller than a diameter of the “portal” outlet of the second path. The device additionally includes, between the pump and the outlet of the first path and/or between the pump and the outlet of the second path, an oxygenation unit arranged to oxygenate the fluid emerging from the “arterial” outlet of the first path more than the fluid emerging from the “portal” outlet of the second path. The device can include a communication path between the first path and the second path in order to oxygenate the second path. Use in liver transplantation.

A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.

The invention relates to a perfusion manifold assembly that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with an assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.

A sensor module has an arterial catheter connection hub. The sensor module has a perfusion inflow hub coupled through an arterial/portal blood chamber to the arterial catheter connection hub. The sensor module has a venous catheter connection hub. The sensor module has an effluent outflow hub coupled through a venous blood chamber to the venous catheter connection hub. The sensor module has an arterial sensor to sense a parameter of an arterial fluid flowing through the arterial/portal blood chamber. The sensor module has a venous sensor to sense a parameter of a venous fluid flowing through the venous blood chamber. The sensor module has a processor coupled to the arterial sensor and the venous sensor to determine a relationship between the parameter sensed by the arterial sensor and the parameter sensed by the venous sensor.

Disclosed herein are polycationic microfibers comprising a high-aspect-ratio polymeric core, the polymeric core comprising a blend of a first core polymer and a second core polymer, and a polycationic polymer immobilized on the surface of the polymeric core. The polycationic microfibers are capable of sequestering or clearing nucleic acids, proteins, biomolecular complexes, exosomes, or microparticles from solutions and samples and may be formed into filters or integrated into filtration apparatuses. Also disclosed are methods for sequestering or clearing solutes from solutions and fluids, methods for the treatment of diseases or conditions, and methods for the prevention of diseases or conditions.

Devices and methods for vascular tissue perfusion. In certain examples, the pressurized oxygen is repetitively pulsed between a lower pressure and a higher pressure and a flexible membrane is deflected to control fluid flow.

A perfusion system includes a perfusate source and a perfusion distributor coupled to the perfusate source and configured to convey oxygen containing perfusate from the perfusate source to tissue and exhaust carbon dioxide generated by the tissue. A carbon dioxide sensor is coupled to sense the carbon dioxide generated by the tissue, which can then be used to provide a measure of tissue viability.

The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.