Disclosed is a container for transporting a biopharmaceutical fluid, the container including a leak-tight wall having an outer portion and an inner portion, the outer portion and the inner portion delimiting between them an intermediate space that may be inflated under pressure with an inflation gas, the container being adapted to be alternately in: a non-inflated state in which the container is empty of pressurized inflation gas; an inflated state in which the wall of the container is inflated and delimits an internal cavity adapted to contain the biopharmaceutical fluid. The wall includes a peripheral lateral wall around the internal cavity, the peripheral lateral wall being completely rigid or semi-rigid when the container is in the inflated state so as to ensure a protection of the biopharmaceutical fluid.

The invention relates to a temperature-control element (4) for a multiwell plate (1), which comprises a plurality of cavities (2) arranged in rows and columns for freezing and/or thawing biological samples. The temperature-control element (4) comprises a base body (6) which is made of a thermally conductive material and is flown through by a temperature-control fluid; and a plurality of protruding temperature-control fingers (5) arranged in rows and columns on an upper side of the base body (6), which are connected in a thermally conductive manner to the base body (6), wherein a grid spacing of the temperature control fingers (5) corresponds to a grid spacing of the cavities (2) of the multiwell plate (1). The invention further relates to a device and method for freezing biological samples, in particular for cryopreservation, and/or thawing biological samples, in particular a cryopreserved sample.

Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.

Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.

The invention discloses a vitrification freezing treatment device for cells. The vitrification freezing treatment device for cells includes a straw device, a pre-freezing device, a freezing unit, a driving device, a control unit and a carrying table used for carrying cell carriers, wherein the straw device is connected with the driving device in a driven mode, the driving device is in signal connection with the control unit, the straw device comprises straws used for obtaining cells in the cell carriers, the control unit is used for controlling the driving device to drive the straw device to obtain cells and to transfer the cells to the freezing unit, and the pre-freezing device is used for pre-freezing the straws when the straw device transfers the obtained cells to the freezing unit.

The present disclosure provides a portable apparatus to maintain temperature of an object comprising a first chamber containing a quantity of a thermal material. The first chamber is thermally coupled to a container holding the object of interest. Ambient air is driven over the thermal material and then towards the container to change the temperature of the container. A valve is provided near the container which can be opened to allow entry of ambient air towards the container. Either of the heated or cooled air flow and the operation of the valve is regulated to maintain the temperature of the container to within a predetermined temperature range. The container is configured to be sealed to isolate the object from the ambient and allows for a means to preserve object quality. A housing of the apparatus is provided with a provision to protect the first container from mechanical shocks.

The present invention generally relates to thawing a cryogenically frozen sample. The systems, devices, and methods may be used to heat a sample holder, the sample holder configured to receive a sample container holding the frozen sample. A sample thaw start time may be identified by measuring a temperature of the sample container and/or a temperature of the sample. A sample thaw end time may be calculated as a function of the sample thaw start time. In some embodiments, the same thaw start time may be identified by a significant change in a first derivative of a warming curve of recorded temperature measurements. The sample end time may be calculated by adding a constant to the sample thaw start time. The constant may be the average sample thaw time per the sample container.

A storage bag (100) for storing, transporting, freezing, and thawing biopharmaceuticals includes a collapsible pouch (102) including an internal volume and an aperture; a non-collapsible port assembly (114) with a body, a snout (118) extending from the body into the pouch through the aperture, and at least one conduit (120A-C); and a reinforcing laminate (108) surrounding the port assembly and the end of the collapsible pouch including the aperture. At least one peripheral cavity (124A, 124B) is adjacent to a portion of the port assembly and extends from the aperture to at least one conduit so the conduit is in fluid communication with the internal volume through the peripheral cavity. The size of the peripheral cavity can be adjusted to control the volume of fluid trapped between the collapsible pouch and the non-collapsible port assembly, and as such this area advantageously experiences limited expansion during freezing.

A method for freeze-drying a biological sample of mammalian cells or tissue including placing a biological sample on or in a structure to increase a temperature of the biological sample and with the biological sample in a closed chamber applying a vacuum to the chamber to lower a pressure within the chamber, cooling the chamber to lower a temperature within the chamber and applying heat to the biological sample within the chamber. The biological sample can include one or more of stem cells, hematopoietic stem cells, mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells, sperm, oocytes, embryos, ovarian tissue, uterine tissue or testicular tissue.

A DSC (Differential Scanning calorimetry) electrode system capable of applying an electric field includes a differential scanning calorimeter, a computer, a signal generator, a self-pressurization liquid nitrogen tank and a reference crucible, wherein the self-pressurization liquid nitrogen tank is connected to the differential scanning calorimeter and used for controlling temperature in real time; the differential scanning calorimeter is connected to the computer and used for transmitting signals and recording experiment results. The DSC electrode system also includes a microelectrode crucible that includes a ceramic crucible, a ceramic crucible cover, welding spots, two electrodes and electrode wires, wherein the two electrodes are respectively fixed in the ceramic crucible; a gap is reserved between the electrodes and used for storing a tested sample; the welding spots are reserved at upper ends of the electrodes.