Acoustophoretic devices and methods for concentrating targeted biological cells in a reduced volume using multi-dimensional acoustic standing waves are disclosed. The methods include flowing a mixture of a host fluid and the biological cells through an acoustophoretic device. The acoustophoretic devices include an inlet, an outlet, and a flow chamber having an ultrasonic transducer-reflector pair. Biological cells, such as T cells, are separated from a host fluid for utilization in allergenic or autologous cell therapies. The disclosed devices and methods are capable of concentrating biological cells to at least 100 times their original cell concentration. The disclosed methods and devices are further capable of decreasing an original feed volume to a final concentrated volume that is less than one percent of the original feed volume.

Acoustophoretic devices and methods for concentrating targeted biological cells in a reduced volume using multi-dimensional acoustic standing waves are disclosed. The methods include flowing a mixture of a host fluid and the biological cells through an acoustophoretic device. The acoustophoretic devices include an inlet, an outlet, and a flow chamber having an ultrasonic transducer-reflector pair. Biological cells, such as T cells, are separated from a host fluid for utilization in allergenic or autologous cell therapies. The disclosed devices and methods are capable of concentrating biological cells to at least 100 times their original cell concentration. The disclosed methods and devices are further capable of decreasing an original feed volume to a final concentrated volume that is less than one percent of the original feed volume.

A piezoelectric driving device includes a vibrating plate, and a piezoelectric vibrating body including a substrate, and piezoelectric elements provided on the substrate. The piezoelectric element includes a first electrode, a second electrode, and a piezoelectric body, and the first electrode, the piezoelectric body, and the second electrode are laminated in this order on the substrate. The piezoelectric vibrating body is installed on the vibrating plate so that the piezoelectric element is interposed between the substrate and the vibrating plate. A wiring pattern including a first wiring corresponding to the first electrode and a second wiring corresponding to the second electrode is formed on the vibrating plate, the first electrode and the first wiring are connected to each other through a first laminated conducting portion, and the second electrode and the second wiring are connected to each other through a second laminated conducting portion.

An exemplary ultrasonic motor includes an ultrasonic actuator, functioning as a waveguide resonator, formed as a rectangular piezo-electrical plate having two main surfaces and side surfaces that join the main surfaces together, an element to be driven and an electrical excitation device. At least one friction element is arranged on at least one side surface of the ultrasonic actuator and is in frictional contact with the element to be driven. The piezo-electrical plate is divided into three parts. The central part forms a generator for an acoustic longitudinal standing wave, and the peripheral parts bordering the central part form generators for an acoustic bending standing wave. Each generator is electrically connected to the electrical excitation device-can be electrically controlled, and can be divided into two equally-sized and electrically individually controllable sub-generators. Each sub-generator has layers of excitation electrodes, layers of general electrodes, and layers of piezo-ceramics arranged therebetween.

A coating device for sealant and a coating method for sealant coating are disclosed. The coating device includes a sealant storage pipe provided with two end portions; one end portion is connected to a gas jet means and the other end portion is connected to a nozzle; a pipe wall of the sealant storage pipe is made from a flexible material; and the pipe wall can be subjected to recoverable inward deformation perpendicular to an axial line of the sealant storage pipe. A coating method for sealant coating, comprising: subjecting a pipe wall to recoverable inward deformation perpendicular to an axial line of a sealant storage pipe during spraying; and subjecting the pipe wall to recovery when the spraying ends.

A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.

A scanning endoscope includes: an optical fiber that guides illumination light for illuminating an object from a proximal end thereof and emits the illumination light from a distal end thereof; an actuator portion provided on a side portion of the optical fiber, for causing the distal end of the optical fiber to oscillate; a holding portion provided on a more proximal end side of the optical fiber than the actuator portion, for holding the optical fiber so as to allow the distal end of the optical fiber to oscillate with the actuator portion; a vibration-absorbing member formed so as to cover a circumference of a part of the optical fiber, the part being located on a more proximal end side than the holding portion and adjacent to the holding portion; and an outer cover that covers a circumference of at least a part of the vibration-absorbing member.

A piezoelectric driving device includes a vibrating plate, and a piezoelectric vibrating body including a substrate, and piezoelectric elements provided on the substrate. The piezoelectric element includes a first electrode, a second electrode, and a piezoelectric body, and the first electrode, the piezoelectric body, and the second electrode are laminated in this order on the substrate. The piezoelectric vibrating body is installed on the vibrating plate so that the piezoelectric element is interposed between the substrate and the vibrating plate. A wiring pattern including a first wiring corresponding to the first electrode and a second wiring corresponding to the second electrode is formed on the vibrating plate, the first electrode and the first wiring are connected to each other through a first laminated conducting portion, and the second electrode and the second wiring are connected to each other through a second laminated conducting portion.

Acoustophoretic devices and methods for concentrating targeted biological cells in a reduced volume using multi-dimensional acoustic standing waves are disclosed. The methods include flowing a mixture of a host fluid and the biological cells through an acoustophoretic device. The acoustophoretic devices include an inlet, an outlet, and a flow chamber having an ultrasonic transducer-reflector pair. Biological cells, such as T cells, are separated from a host fluid for utilization in allergenic or autologous cell therapies. The disclosed devices and methods are capable of concentrating biological cells to at least 100 times their original cell concentration. The disclosed methods and devices are further capable of decreasing an original feed volume to a final concentrated volume that is less than one percent of the original feed volume.

An electric device includes an electric component that includes an electrode terminal which includes a projection portion, and a circuit substrate that includes a connected portion which is electrically connected to the projection portion, in which the connected portion includes a recess portion that is in contact with the projection portion.