A synchronization condition setting processing unit receives a user's selection regarding an MRM transition for which the timing of starting voltage application to a probe is to be synchronized with the timing of starting analysis. A mass spectrometry control unit controls a mass spectrometric unit to repeat a cycle of executing MRM measurement of a plurality of preset MRM transitions, while an ionization control unit controls a PESI ion source to alternately repeat an up-and-down movement of the probe and high voltage application to the probe, and at that time, a synchronization control unit controls control operations of a mass spectrometry control unit and an ionization control unit such that timings of start of the MRM measurement for the MRM transition selected by the user and start of application of voltage to the probe match.

A sample support for polymer-spray mass spectrometry includes a support substrate comprising a polymer. The support substrate is configured to support a sample on a surface of the support substrate. The sample support also includes a reservoir formed on the surface of the support substrate. The reservoir is configured to hold a spray solvent.

The invention provides hybrid mass spectrometric systems which comprise an ion source, a first trapped ion mobility spectrometry (TIMS) analyzer and a mass analyzer, wherein the TIMS analyzer is located and operated in a first vacuum chamber at an elevated pressure above 500 Pa, and methods for operating the hybrid mass spectrometric systems.

Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

An ultrasonic transmitter (95) and detector (e.g., integrated as an ultrasound transducer) utilized in a feedback control system automatically monitors and/or detects surface profile (e.g., shape) of the liquid-air interface and adjusts the flow rate of sampling liquid to ensure that experimental conditions remain consistent at the time of sample introduction during serial samplings. The feedback control can provide for automated adjustment of the surface profile of the liquid-air interface in accordance with changes in desired set point according to an experimental workflow (e.g., automated adjustment between an interface corresponding to a vortex sampling set point and an overflow cleaning set point). Improvements in desorption efficiency and quality of mass spectrometry data by degassing of the liquid solvent utilized within the sampling interfaces, and/or utilization in a feedback control system for generating data indicative of a surface profile of the liquid-air interface within the interface's sampling port may be realized.

A method and system for injecting a sample into a receiving LC/MS/MS system that is configured to determine a concentration of GenX within the sample, wherein the LC/MS/MS includes ESI. The sample is subjected to one or more of the following ESI conditions: i) a probe gas temperature of approximately 120° C. to approximately 160° C.; ii) a sheath gas heater setting of approximately 150° C. to approximately 275° C.; and iii) a sheath gas flow of approximately 6 L/min to approximately 11 L/min. The concentration of GenX within the sample may have a minimum reporting level of approximately 0.010 μg/L.

An analysis method includes: performing liquid chromatography using a mobile phase including an adsorption prevention agent for preventing adsorption of a sample including a compound having a phosphate group to metal; and performing mass spectrometry on an eluate of the liquid chromatography. The adsorption prevention agent includes an oxalic acid or a salt of the oxalic acid.

A heater for ionization is used to produce ions from a sample. The heater for ionization has a bobbin, an electric heating wire and an electrode. The bobbin extends in one direction. The electric heating wire is wound around the bobbin. The electrode is welded to the electric heating wire. In the bobbin, a groove portion extending in the one direction is formed. The electrode is fitted into the groove portion.

Apparatus, systems, and methods in accordance with various aspects of the applicant's teachings provide for improved interfaces for providing a sample flow from a sample conduit (e.g., an analytical conduit or capillary), including those used in sample separation techniques such as CE and HPLC, to an ESI source for ionization thereby.

Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for minimally invasive collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.