The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, nicotine salts with orotic acid are described. The invention further provides methods of preparation and characterization of such nicotine salts. In addition, tobacco products, including smoking articles, smokeless tobacco products, and electronic smoking articles comprising nicotine salts, co-crystals, and/or salt co-crystals are also provided.

Embodiments described herein provide a method of making a tobacco extract comprising; (a) contacting tobacco with an extraction solvent in a first chamber such that tobacco components are extracted from the tobacco into the extraction solvent, wherein the extraction solvent is a supercritical fluid in the first chamber; (b) passing the extraction solvent containing tobacco components along a line towards a second chamber, wherein a valve is present in the line and the conditions downstream of the valve are such that the extraction solvent is subcritical; and (c) pumping entrapment solvent into a flow downstream of the valve, wherein the tobacco components are released from the extraction solvent by transfer to subcritical conditions and are dissolved in the entrapment solvent, whereby the tobacco components dissolved in entrapment solvent are collected in the second chamber.

The invention provides Embodiments described herein include a method of making a tobacco extract comprising; (a) providing tobacco and an entrapment solvent in a partitioned vessel, wherein the tobacco and entrapment solvent are separated by the partition, and the vessel is configured such that the tobacco and entrapment solvent cannot contact each other; (b) flowing a supercritical extraction solvent through the vessel, wherein the extraction solvent and any dissolved substances can pass through the partition; whereby tobacco components are extracted from the tobacco into the extraction solvent and carried across the partition, wherein the extraction solvent contacts the entrapment solvent and tobacco components are transferred from the supercritical extraction solvent into the entrapment solvent.

Embodiments described herein include a method of making a tobacco extract comprising; (a) contacting tobacco with an extraction solvent at a first temperature and first pressure which are selected such that the extraction solvent is supercritical, such that tobacco flavor and/or aroma components are extracted from the tobacco into the solvent; (b) separating the residual tobacco solids from the supercritical extraction solvent containing tobacco components; (c) exposing the extraction solvent containing tobacco components to conditions in a vessel at which the extraction solvent is subcritical, thereby releasing the tobacco components from the extraction solvent, (d) contacting the residual tobacco solids with an extraction solvent at a second temperature and second pressure which are selected such that the extraction solvent is supercritical, such that nicotine are extracted from the tobacco into the extraction solvent; and wherein the second temperature and/or second pressure is higher than the respective first temperature or first pressure; (e) separating the residual tobacco solids from the supercritical extraction solvent containing tobacco components; (f) exposing the extraction solvent containing tobacco components to conditions in a vessel at which the extraction solvent is subcritical, thereby releasing the tobacco components from the extraction solvent, wherein during step (f), the vessel contains an entrapment solvent which dissolves the tobacco components released from the extraction solvent, and wherein the entrapment solvent comprises an aerosol generating agent.

The present invention provides a delivery vehicle for functionalizing an aerosol in proximity to the delivery vehicle, wherein the delivery vehicle comprises a porous substrate material comprising at least one porous thermoplastic polymer and at least one formulation held within the thermoplastic polymer, wherein the formulation comprises at least one functionalizing component and the porous thermoplastic polymer has a formulation loading capacity of at least 30% w/w based on the porous substrate.

Various embodiments of the present invention provide a method and a system. The system having an appetite control device for covering a plurality of teeth, wherein the appetite control device comprises an arcuate shape having an outer sidewall, an inner sidewall and a top wall connecting the inner sidewall and outer sidewall to form a channel, wherein the channel is configured for receiving a plurality of teeth, wherein the appetite control device includes a larger width at ends and a narrower width at a front. The system further includes a user device having a memory and a processor configured to execute executable instructions stored in the memory to receive data associated with usage of the appetite control device and determine an output data associated with appetite information of the user based on analysis of the received data using a pre-trained machine learning model.

A method of producing a liquid tobacco extract is provided, the method including the steps of: preparing a tobacco material; heating the tobacco material at an extraction temperature of between 100 degrees Celsius and 160 degrees Celsius for at least 15 minutes, the tobacco material being heated directly; collecting volatile compounds released from the tobacco material during the heating step; and forming a liquid tobacco extract including the collected volatile compounds, the tobacco material being microwave heated during at least one step of the method. A liquid tobacco extract produced by the method is also provided.

Disclosed herein is an inhalable composition, suitable for use in an electronic cigarette device, comprising at least 1 g/L of nicotine and at least 2 g/L of carbon dioxide dissolved or dispersed in a solvent comprising glycerol and water, wherein the molar ratio of carbon dioxide to nicotine is at least 0.1:1;

wherein glycerol is present in an amount of at least 40% by weight, based on the total weight of the inhalable composition;

wherein water is present in an amount of 1-20% by weight, based on the total weight of the inhalable composition; and

wherein propylene glycol, when present, is present in an amount of no more than 10% by weight, based on the total weight of the inhalable composition.

The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, nicotine salts with orotic acid are described. The invention further provides methods of preparation and characterization of such nicotine salts. In addition, tobacco products, including smoking articles, smokeless tobacco products, and electronic smoking articles comprising nicotine salts, co-crystals, and/or salt co-crystals are also provided.

A nicotine pouch composition is disclosed, the pouch composition comprising free-base nicotine and having a water content of at least 15% by weight of said pouch composition. Furthermore, an oral nicotine pouch product comprising the pouch composition and a method for manufacturing the oral nicotine pouch product is disclosed.