A multi-bus wireless communication system is disclosed. The multi-bus wireless communication system includes a network access circuit and a radio access circuit, which are physically separated but interconnected via a coaxial bus(es). The radio access circuit includes an antenna(s) and an electronic device(s) for optimizing the antenna(s) based on a bus telegram(s) communicated over a single-wire bus(es). The network access circuit generates and multiplexes the bus telegram(s) with a radio frequency (RF) signal(s) for communication to the radio access circuit over the coaxial bus(es). The radio access circuit, sequentially, demultiplexes the multiplexed signal(s) into the RF signal(s) and the bus telegram(s). Accordingly, the radio access circuit can control the electronic device(s) to optimize the antenna(s). By multiplexing and demultiplexing the RF signal(s) and the bus telegram(s) on opposite ends of the multi-bus wireless communication system, it is possible to optimize the antenna(s) over the coaxial bus(es) in a vehicular environment.