Apparatuses, systems and methods for generating color video with a monochrome sensor include the acts of (i) selectively energizing each of a plurality of light sources in a sequence, (ii) capturing a monochrome image of the illuminated sample at a monochrome sensor at each stage of the sequence, and (iii) generating a color video from the monochrome images. The sequence can have a series of stages with each stage of the sequence corresponding to activation of a different wavelength of light from the light sources to illuminate a sample. Generating the monochrome video can include the acts of compiling a plurality of monochrome images captured at the monochrome sensor with a single light source into a series of monochrome video frames comprising the monochrome video.

Some embodiments are directed to an imaging that includes an image sensor; a tunable filter; and a controller operatively connected to the tunable filter and to the image sensor. The imaging system is configured to: tune the tunable filter to a plurality of filter states. The image sensor acquires, at each state of the plurality of states, an image of an object, to provide different images of the object. The controller calculates a state related score, for each state that is indicative of one or more properties of at least one subset of pixels of the at least one image acquired at the state, to provide a plurality of state related scores; and determines, based on at least one of the plurality of state related scores, a desired state of the tunable filter that satisfies a desired state related score criterion; and sets the tunable filter.

An imaging system includes an image sensor having an array of sensor pixels, a multi-chromatic illuminator adapted to independently generate a plurality of illumination colors each having a different finite spectral range, and a controller coupled to the image sensor and to the multi-chromatic illuminator. The controller includes logic to time-multiplexing the multi-chromatic illuminator between the illumination colors. Each of the illumination colors independently illuminates for at least a corresponding one of non-overlapping durations of illumination of the illumination colors. The controller includes further logic to acquire chromatic sub-images with the image sensor and combine the chromatic sub-images into a composite color image. Each of the chromatic sub-images is acquired during a different one of the non-overlapping durations of illumination.

The disclosure extends to methods, systems, and computer program products for producing an image in light deficient environments and correction of white balance and/or fixed pattern noise at startup or at any other time during a procedure.

According to an aspect, there is provided an image sensing system comprising: a rolling shutter image sensor comprising an array of pixels in a frame arranged into a plurality of image lines extending along a width direction, and distributed in a scanning direction which is perpendicular to the width direction, wherein the rolling shutter image sensor is configured to scan the frame by sequentially scanning each image line along the scanning direction, wherein scanning each image line includes making the pixels in each image line sensitive to light for a predetermined exposure time, and then determining an intensity readout for each pixel of the respective image line; a lens system configured to project at least two similar outgoing images of an object onto the image sensor, the outgoing images offset from one another in the scanning direction, wherein the outgoing images are projected onto the image sensor such that each pixel of an outgoing image corresponding to a position on the object matches a pixel or group of pixels of another outgoing image corresponding to the respective position on the object; a light generator configured to generate at least two different colours of light, defined by different wavelengths, to illuminate the object; a timing module configured to control the light generator to sequentially generate at least two different colours of light during scanning of a single frame; and a processor configured to identify matched pixels of different outgoing images corresponding to a respective position on the object, and to resolve the colour spectrum of the respective position of the object based on the intensity readout of each matched pixel and the colours of light that the respective matched pixels were exposed to while they were sensitive.

Apparatuses, systems and methods for generating color video with a monochrome sensor include the acts of (i) selectively energizing each of a plurality of light sources in a sequence, (ii) capturing a monochrome image of the illuminated sample at a monochrome sensor at each stage of the sequence, and (iii) generating a color video from the monochrome images. The sequence can have a series of stages with each stage of the sequence corresponding to activation of a different wavelength of light from the light sources to illuminate a sample. Generating the monochrome video can include the acts of compiling a plurality of monochrome images captured at the monochrome sensor with a single light source into a series of monochrome video frames comprising the monochrome video.

The disclosure extends to methods, systems, and computer program products for producing an image in light deficient environments and correction of white balance and/or fixed pattern noise at startup or at any other time during a procedure.

Apparatuses, systems and methods for generating color video with a monochrome sensor include the acts of (i) selectively energizing each of a plurality of light sources in a sequence, (ii) capturing a monochrome image of the illuminated sample at a monochrome sensor at each stage of the sequence, and (iii) generating a color video from the monochrome images. The sequence can have a series of stages with each stage of the sequence corresponding to activation of a different wavelength of light from the light sources to illuminate a sample. Generating the monochrome video can include the acts of compiling a plurality of monochrome images captured at the monochrome sensor with a single light source into a series of monochrome video frames comprising the monochrome video.

The disclosure extends to methods, systems, and computer program products for producing an image in light deficient environments and correction of white balance and/or fixed pattern noise at startup or at any other time during a procedure.

An imaging apparatus for use with a subject may include a light source structured to irradiate the subject with a yellow light, a magenta light and a cyan light at a delayed illumination timing; and a plurality of photodetectors structured to detect the intensity of the light coming from the subject when the yellow light is irradiated, the intensity of the light coming from the subject when the magenta light is irradiated, and the intensity of the light coming from the subject when the cyan light is irradiated.