An imaging system for cell-based therapies is provided. The imagining system includes one or more optical tags configured for insertion into a cell or biological tissue, an excitation light source configured to illuminate the one or more optical tags; a detector configured to measure optical emission of the one or more optical tags; an imaging subsystem configured to determine a three-dimensional location of each of the one or more optical tags in the cell or biological tissue; and a controller in electrical communication with the excitation light source, the detector, and the imaging subsystem. Each of the one or more optical tags has a contrasting feature and includes a fluorescent material. The contrasting feature may be defined by at least one of a refractive index, shape, color, and laser emission of each optical tag of the one or more optical tags.

Retinal layer segmentation in optical coherence tomography (OCT) data is improved by using OCT angiography (OCTA) data to enhance a target retinal layer within the OCT data that may lack sufficient definition for segmentation. The OCT data is enhanced based on a mixture of the OCT data and OCTA data, such that contrast in the OCT data is enhanced in areas where OCT and OCTA data are dissimilar, and is reduced in areas where the OCT and OCTA data are similar. The target retinal layer in the OCT data is segmented based on the enhanced data. Two en face images of the OCTA data that include the target retinal layer are used to check for errors in the segmentation of the target retinal layer in the OCT data. Identified errors are replaced with an approximation based on the locations of top and bottom retinal layers of one of the en face images.

A system, method, or device for imaging the anterior segment of an eye includes a contactless adapter/lens that may be attached to an existing ophthalmic imaging system to redirect the imaging system's light beam to traverse the pupil of the eye at a steep angle. In particular, the steep angle is determined to permit the ophthalmic imaging system to image zonules under the iris, and which would typically be blocked by the iris and not accessible for imaging.

A fundus image processing apparatus including a controller configured to perform image acquisition processing of acquiring a three-dimensional tomographic image of the fundus of the subject eye, reference position setting processing of setting a reference position in a region of an optic nerve head in the two-dimensional measurement region in which the three-dimensional tomographic image was captured, radial pattern setting processing of setting a radial pattern with respect to the two-dimensional measurement region, image extraction processing of extracting a two-dimensional tomographic image in each of a plurality of lines of the radial pattern set in a redial pattern setting processing, and optic nerve head end detection processing of detecting a position of an end of the optic nerve head captured in the three-dimensional tomographic image.

Systems and methods for performing a retinal angiogram, which can be used to non-invasively quantify retinal perfusion by measuring differences in retinal vascular density. The systems and methods can be used to measure a response of the vasculature, particularly in the choriocapillaris. The systems and methods can be used to diagnose neurodegenerative conditions, associated sleep and mood disorders, and measure metabolic reserve. In particular, the systems and methods can also be used for both diagnostics and prognostics.

A scanning apparatus includes a scanner configured to move a scanning spot along a movement path to capture three-dimensional information of a target object. The movement path includes a plurality of b-scan paths performed along a c-scan path. The scanning apparatus also includes a processing circuit configured as a controller to control the movement path of the scanning spot. An area of the target object covered by the movement path may be independent of a length of the b-scan path. The processing circuit may be configured as an analyzer configured to determine a saturation time for each three-dimensional position within a portion of the target object based on an inter-scan time.

An image processing method including acquiring a fundus image, extracting a first area including a first feature from the fundus image, extracting a second area including a second feature different from the first feature from the fundus image, and generating a combined image in which the extracted first area and the extracted second area are combined.

A medical system according to an aspect example includes a data acquiring unit and a data processor. The data acquiring unit is configured to acquire from a patient two or more types of data among blood oxygen saturation data, auscultatory sound data, ocular image data, and ocular blood flow data. The data processor is configured to process the two or more types of data acquired by the data acquiring unit to detect a conditional change in a circulatory system associated with an infectious disease.

Various systems, processes, and computer program products may be used to perform retinal laser surgery. In particular implementations, systems, processes, and computer program products may include the ability to identify retina blood vessels from a retina image and determine a retina location needing therapy and not substantially intersecting a retina blood vessel. The systems, processes, and computer program products may also include the ability to generate a command to activate a retinal laser when a beam from the retinal laser will be aligned with the therapeutic location.

In an embodiment, cross sectional image storage stores a cross sectional image group including multiple cross sectional images each of which is associated with time. Phase image storage stores a phase image group including multiple phase images each of which is associated with time. Blood flow information storage stores a blood flow information group including multiple blood flow information each of which is related to blood flow in a blood vessel of the living body and is associated with time. Display synchronously displays a cross sectional image included in the cross sectional image group and a phase image included in the phase image group using time associated with the cross sectional image and the phase image, and displays a blood flow image that expresses multiple blood flow information. The display performs the same change as the change to the cross sectional image, the phase image and the blood flow image.