Methods of applying OCT angiography are disclosed. In particular, methods of detecting, visualizing and measuring the extent of retinal neovascularization are disclosed. Further disclosed are methods measuring retinal nonperfusion area and choriocapillaris defect area.

The present invention provides an ophthalmic device capable of minimizing the generation of flare at a lower cost and in a shorter time than in the prior arts when photographing in a state where an optical axis of an examination optical system is deviated from a reference position of a subject eye. The ophthalmic device according to an embodiment of the present invention includes a photographing unit that images a region to be observed of the subject eye through the examination optical system, a first alignment unit that performs alignment on the examination optical system with respect to the subject eye in the optical axis direction and the direction perpendicular to the optical axis direction, an optical system movement unit that moves the examination optical system from a first position aligned by the first alignment unit to a second position which is deviated from the first position at least in the perpendicular direction, and a second alignment unit that determines an alignment position in the optical axis direction of the examination optical system with respect to the subject eye at the second position based on the positional difference between the first position and the second position and moves the examination optical system to the alignment position along the optical axis direction.

A blood flow measuring unit of a blood flow measurement apparatus of an embodiment includes an optical system for applying an OCT scan to an eye fundus and obtains blood flow information based on data acquired by the OCT scan. A movement mechanism moves the optical system. A controller applies a first movement control to the movement mechanism to move the optical system in a first direction orthogonal to an optical axis of the optical system by a predetermined distance from the optical axis. A judging unit judges occurrence of vignetting based on a detection result of return light of light incident on the eye through the optical system after the first movement control. The controller applies a second movement control to the movement mechanism to further move the optical system based on a judgement result obtained by the judging unit.

Disclosed herein are methods and systems for capillary oximetry (e.g., retinal capillary oximetry) using optical coherence tomography (OCT). The method may include obtaining an OCT angiography dataset, performing capillary segmentation based on the OCT angiography dataset to obtain capillary segments, resampling, registering, and/or averaging B-scans of the OCT angiography dataset that correspond to a first capillary segment of the capillary segments to obtain an averaged B-scan for the first capillary segment, determining an anterior and posterior border of the first capillary segment, and determining an oxygen saturation of the first capillary segment based on the averaged B-scan, the anterior border, and the posterior border. Other embodiments may be described and claimed.

The present disclosure provides methods for preventing or treating ocular diseases such as diabetic retinopathy and diabetic macular edema, wherein the methods include administering non-invasive photobiomodulation light therapy comprising a light having a wavelength in a red wavelength range. Biomarkers and diagnostic assays for selecting a treatment are also provided.

This invention relates to, in part, methods and compositions that are useful for the diagnosis, treatment, or prevention of a blinding eye disease, including in the discovery of drugs that are efficacious against these diseases. Diseases include, for example, age related macular degeneration and reticular pseudodrusen disease, and the methods described herein include, for example, the method named delayed near infrared analysis (DNIRA).

A storage device of an ophthalmologic image display device of an embodiment stores a three dimensional data set acquired by scanning a subject's eye using OCT. An image processor forms, based on the three dimensional data set, a B-mode image, front images, and composite front image obtained from the front images. A display controller displays the B-mode image, front images and composite front image in a predetermined layout. The display controller displays distinguishment color information for distinguishment between the front images by colors and slice area information that indicates a partial region of the B-mode image corresponding to a slice area of the three dimensional data set represented by each front image in a color according to the distinguishment color information, and displays a composite front image based on the front images, each of which is expressed by a color according to the distinguishment color information.

Relationships between morphological changes to an eye due to intraocular pressure changes and blood perfusion changes in the retina are determined by colocalizing retinal perfusion data and optic nerve head (ONH) mechanical deformation data. Perfusion changes from intraocular pressure (IOP) changes are determined by colocalizing retinal perfusion data with ONH mechanical deformation data. Optical coherence tomography-angiography (OCT-A) can be used to generate both retinal perfusion data and mechanical deformation data for an imaged volume. A three-dimensional model (e.g., connectivity map or connectivity model) of the vasculature can be generated from the OCT-A imaging data and used to predict changes in blood perfusion in various areas of the retina due to IOP-induced mechanical deformations.

Imaging various regions of the eye is important for both clinical diagnostic and treatment purposes as well as for scientific research. Diagnosis of a number of clinical conditions relies on imaging of the various tissues of the eye. The subject technology describes a method and apparatus for imaging of the back and/or front of the eye using multiple illumination modalities, which permits the collection of one or more of reflectance, spectroscopic, fluorescence, and laser speckle contrast images.

An exemplary OCT apparatus includes a scanner, controller, phase information generator, phase information processor. The scanner applies an OCT scan to an object using an optical scanner. The controller controls the scanner to perform a first scan that scans a cross section of the object in a first scan direction and a second scan that scans a cross section of the object in a second scan direction opposite to the first scan direction. The phase information generator generates first phase information based on first acquisition data acquired by the first scan and second phase information based on second acquisition data acquired by the second scan. The phase information processor generates composite phase information based on the first phase information and the second phase information.