The disclosure relates to methods, systems, and computer program products for registering a set of X-ray images with a navigation system. In the method, by a camera, at least one image of a reference object is recorded and, on the basis thereof, a current posture of the reference object is determined. It is then checked whether this posture fulfils a specified criterion, which also on an arrangement of the reference object at least partially outside a planned reconstruction volume of the X-ray device, predicts an expected successful registration. On non-fulfillment of the criterion, a signal for adaptation of a relative alignment between the X-ray device and the reference object is automatically output. On fulfillment of the criterion, the X-ray images of the reference object are recorded, the posture of the reference object is determined, and the registration is carried out using the determined postures as reference.

A method of performing a radiological biopsy and associated system includes scanning a living human subject with a CT scanner to locate coordinates of an area of potential pathology and then using the coordinates to direct synchrotron radiation to a location at, or proximate the coordinates to obtain a high-resolution image of the area of potential pathology. The CT scan is accomplished with a CT scanner such as a C-Arm, vertical or horizontal CT scanner. A synchrotron radiation source emits synchrotron radiation through the subject and is processed by a processing system. The method and system allow for concurrent or sequential scanning of the subject by the CT scanner and synchrotron radiation scanner. The resulting images provide histological resolution of areas of potential pathology.

Systems, methods, and devices for medical imaging are disclosed herein. In some embodiments, a method for imaging an anatomic region includes receiving, from a detector carried by an imaging arm of an x-ray imaging apparatus, a plurality of images of the anatomic region. The images can be obtained during manual rotation of the imaging arm. The imaging arm can be stabilized by a shim structure during the manual rotation. The method can also include receiving, from at least one sensor coupled to the imaging arm, pose data of the imaging arm during the manual rotation. The method can further include generating, based on the images and the pose data, a 3D representation of the anatomic region.

Phase contrast and dark-field X-ray imaging enable imaging of objects that absorb or reflect very little X-ray light. Disclosed is a method and systems for performing coded-mask-based multi-contrast imaging (CMMI). The method includes providing radiation to a coded mask that has a known phase and absorption profile according to a pre-determined pattern. The radiation is then impingent upon a sample, and the radiation is detected to perform phase-reconstruction and image processing. The method and associated systems allow for the use of maximum-likelihood and machine learning methods for reconstruction images of the sample from the detected radiation.

An apparatus, system and method for calibrating an x-ray apparatus including acquiring sinogram data by scanning a symmetrical phantom using a plurality of detector channels; generating mirror-copied sinogram data by mirror-copying at least one of first sinogram data and second sinogram data of the acquired sinogram data, wherein the first sinogram data and the second sinogram data are generated by dividing the sinogram data at a center detector channel of the plurality of detector channels; outputting a first reconstructed image by reconstructing the mirror-copied sinogram data; and determining a calibration parameter based on the first reconstructed image.

A mobile radiography apparatus includes radiopaque markers disposed in a radiation path that extends from an x-ray source to a digital radiographic detector, which detector is mechanically uncoupled from the x-ray source or x-ray sources. A processing system calculates a position of the detector relative to the x-ray source or x-ray sources according to identified marker positions in acquired x-ray projection images, and reconstructs a volume image according to the acquired x-ray projection images.

A device and methods for performing a simulated CT biopsy on a region of interest on a patient. The device comprises a gantry (22) configured to mount an x-ray emitter (24) and CT detector (26) on opposing sides of the gantry, a motor (28) rotatably coupled to the gantry such that the gantry rotates horizontally about the region of interest, and a rotation of source high resolution x-ray detector (172) positioned adjacent the CT detector in between the CT detector and the x-ray emitter.

A radiographic image capturing system includes: a mammography apparatus that emits radiation having a first energy to a subject and captures a first radiographic image with a radiation detector and emits radiation having a second energy greater than the first energy to the subject and captures a second radiographic image with the radiation detector and that captures the first radiographic image and the second radiographic image with a breast in a state in which a contrast medium using iodine is administered. The radiographic image capturing system includes a phantom for evaluation of the mammography apparatus that has a solid material containing at least one element, which has a value of a k absorption edge that is equal to or greater than the first energy and equal to or less than the second energy, as an image evaluation pattern simulating the contrast medium.

Various embodiments of the present disclosure include a C-arm registration system employing a controller (70) for registering a C-arm (60) to a X-ray ring marker (20). The X-ray ring marker (20) includes a coaxial construction of a chirp ring (40) and a centric ring (50) on an annular base (30). In operation, the controller (70) acquires a baseline X-ray image illustrative of the X-ray ring marker (20) within a baseline X-ray projection by the C-arm (60) at a baseline imaging pose, derives baseline position parameters of the X-ray ring marker (20) within the baseline X-ray projection as a function of an illustration of the centric ring (50) within the baseline X-ray image, and derives a baseline twist parameter of the X-ray ring marker (20) within the baseline X-ray projection as a function of the baseline position parameters and of an illustration of the chirp ring (40) within the baseline X-ray image.

A location tracking system maps anatomical structures in a first coordinate system, in a fixed position within a medical imaging system, which captures 3D images in a second coordinate system. The 3D images are converted to and stored in a standardized format in a third coordinate system in accordance with a first coordinate transformation. A first 3D image captured by the imaging system is registered with the first coordinate system so as to produce a second coordinate transformation. The first and second coordinate transformations are combined so as to derive a third coordinate transformation between the first and third coordinate systems. A second 3D image of a body of a subject, captured by the imaging system, is processed in order to extract image features in the third coordinate system. The extracted image features are joined with location data captured by the location tracking system by applying the third coordinate transformation.