Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the thrombectomy system. The system can include a catheter having a distal portion configured to be positioned adjacent to a thrombus in a blood vessel, an electrode disposed at the distal portion of the catheter, and an interventional element configured to be delivered through a lumen of the catheter. The electrode and the interventional element are each configured to be electrically coupled to an extracorporeal power supply.

An electrosurgical system includes an electrosurgical generator and an electrosurgical instrument coupleable to the electrosurgical generator. The electrosurgical generator includes a controller, a power supply coupled to the controller, and a power converter coupled to the power supply. The controller is configured to cause the power converter to generate a pulsed electric field configured to electroporate tissue and RF current configured to seal tissue. The electrosurgical instrument includes a pair of opposing jaw members configured to grasp tissue. Each of the pair of opposing jaw members includes an electrically conductive tissue-contacting surface configured to electroporate tissue disposed in proximity to the electrically conductive tissue-contacting surfaces via the pulsed electric field and deliver the RF current to the electroporated tissue to seal the electroporated tissue.

A surgical instrument assembly is disclosed. The surgical instrument assembly comprises a housing, a shaft assembly configured to be operably attached to the housing, a retraction assembly configured to manually retract a firing member, and a lock operably coupled with the retraction assembly and a drive unit.

Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the thrombectomy system. The system can include a catheter having a distal portion configured to be positioned adjacent to a thrombus in a blood vessel, an electrode disposed at the distal portion of the catheter, and an interventional element configured to be delivered through a lumen of the catheter. The electrode and the interventional element are each configured to be electrically coupled to an extracorporeal power supply.

Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the thrombectomy system. The system can include a catheter having a distal portion configured to be positioned adjacent to a thrombus in a blood vessel, an electrode disposed at the distal portion of the catheter, and an interventional element configured to be delivered through a lumen of the catheter. The electrode and the interventional element are each configured to be electrically coupled to an extracorporeal power supply.

The disclosure provides an example electrosurgical system and methods for use thereof. The electrosurgical system includes a high-frequency inverter (“HFI”) having a full bridge and a control system electrically coupled to the HFI. The control system controls output parameters including one or more of an output power P.sub.out(t) and an output voltage or current by varying power reference P.sub.ref(t) or switch states of the HFI. The control system causes a power adaptation ΔP(t) to a preset power set P.sub.set based on receiving at least one of impedance feedback and thermal feedback according to the following relationship: P.sub.ref(t)=P.sub.set+ΔP(t).

A method of non-thermally ablating undesirable tissue in the body by application of pulsed, bipolar, instant charge reversal electrical fields of sufficient energy to cause complete and immediate cell membrane rupture and destruction. Energy is delivered through radio frequency pulses of particular frequencies, wave characteristics, pulse widths and pulse numbers, such that enhanced physical stresses are placed on the cell membrane to cause its immediate and complete destruction thereby spilling the entire cell content and membrane constituents into, the extracellular space without denaturing proteins so as to enable an immunological response to destroy and remove the target tissue and similarly marked tissue elsewhere in the subject.

Various aspects of the present invention are directed to apparatuses, systems, and methods that may include a tissue ablation system. The tissue ablation system may include an ablation device; an ablation generator; and a controller configured to cause the ablation generator to apply a first power level to the ablation device and cause the ablation generator to apply a second power level to the ablation device, the second power level being higher than the first power level; the power provided by the ablation generator to the ablation device is adjusted from the first power level to the second power level, adjusting the power from the first power level to the second power level includes causing the ablation generator to provide a plurality of distinct intermediate power levels corresponding to delivering a plurality of intermediate energy levels from the ablation device, and each of the intermediate power levels is between the first power level and the second power level.

A catheter system includes a power source, a controller, and a light guide. The power source generates a plurality of energy pulses. The controller controls the power source so that the plurality of energy pulses cooperate to produce a composite energy pulse having a composite pulse shape. The light guide receives the composite energy pulse. The light guide emits light energy in a direction away from the light guide to generate a plasma pulse away from the light guide. The power source can be a laser and the light guide can be an optical fiber. Each of the energy pulses has a pulse width, and the energy pulses are added to one another so that the composite energy pulse has a pulse width that is longer than the pulse width of any one of the energy pulses. At least two of the energy pulses can have the same wavelength as or a different wavelength from one another.

Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the thrombectomy system. The system can include a catheter having a distal portion configured to be positioned adjacent to a thrombus in a blood vessel, an electrode disposed at the distal portion of the catheter, and an interventional element configured to be delivered through a lumen of the catheter. The electrode and the interventional element are each configured to be electrically coupled to an extracorporeal power supply.