The invention relates to a device for treating biological tissue (19), comprising a light source (14) for sending a plurality of light pulses (15) to the tissue (19) within a treatment time period (31) in order to cause the tissue (19) to vibrate. The device comprises a vibration sensor (21), which senses the amplitude of a vibration (22) of the tissue (19) brought about by the light source (14). A control unit (16) calculates a relative value (30) by putting a current measurement value (27) of the amplitude in a ratio with an initial measurement value (26) of the amplitude. The control unit (16) processes the relative value (30) in order to generate a control signal for the light source (14).

A device and a method, which is individual to a patient, treat malignant diseases by using selectively acting tumor-destructive mechanical pulses (TMI). The tumor-destructive pulse shapes and frequency are determined using physical cell properties, which are individual to each patient. The device is controlled in such that lethal pulse fields are applied in the tumor area.

An ultrasonic instrument includes a body, an actuation assembly, a shaft assembly, and an end effector. The actuation assembly includes a mode selection member and an activation member. The shaft assembly extends distally from the body. The shaft assembly includes an acoustic waveguide. The end effector includes an ultrasonic blade. The ultrasonic blade is in acoustic communication with the acoustic waveguide. The end effector is configured to be activated in a first activation mode in response to actuation of the activation member when the mode selection member is in a first position. The end effector is configured to be activated in a second activation mode in response to actuation of the activation member when the mode selection member is in a second position.

Various embodiments of the systems, methods, and devices are provided for controlled operation of an intravascular lithotripsy system for breaking up calcified lesions in an anatomical conduit. More specifically, control arrangements are disclosed concerning managing and/or providing electrical energy to generate an electrical arc between a set of spaced-apart electrodes disposed within a fluid-filled member configured to contain a conductive fluid.