A method of suturing includes: (1) wrapping a first segment of a suture through a traction loop; (2) pulling the traction loop and the first segment through an opening in a suture lock; (3) continuing to pull the traction loop such that a second segment of the suture extends through the opening, wherein the second segment has a greater denier than the first segment such that the second segment more nearly fills an entire dimension of the opening than the first segment; and (4) locking the suture in place with the second segment in the opening.

Systems and methods for preparing a ligament graft for a ligament reconstruction procedure are provided. In general, the described techniques utilize a graft preparation system having a holder and a delivery suture assembly removably coupled thereto. The delivery suture assembly can include a spine coupled with an anchor suture configured to form a self-tightening knot used to position the assembly around a graft and a plurality of suture windings configured to be affixed to the graft when the assembly is deployed. The assembly is delivered to the graft using the holder and the sutures can be affixed to the graft without penetrating therethrough. The spine helps to evenly distribute the load among the windings compressing the graft which are thus are capable of withstanding increased loads. Thus, an improved, simplified, and time- and labor-saving approach to preparing ligament grafts is provided.

Various devices, systems, and methods for anchoring sutures are provided In general, a suture anchor can include a groove formed in an exterior surface thereof and configured to seat a suture at least partially therein. The suture can be configured to automatically become seated in the groove during the advancement of the anchor into bone, such as by being rotated therein using a driver tool. The suture and the groove can have cooperating sizes such that the suture seated in the groove extends radially outward therefrom to be partially located outside of the anchor. This external portion of the suture can be press fit between the anchor and the bone, thereby securing both the anchor and the suture to the bone. This securing can occur as part of driving the anchor into bone.

A method of making a surgical braid. The method comprises moving a plurality of bobbins along an active track, the active track being an endless track; and selectively moving a bobbin to a passive track while continuing to move the remaining bobbins along the active track.

A method of making a cut braid. The method comprises moving a plurality of bobbins around an endless track in a braiding machine; braiding a plurality of strands from the bobbins into a braid; passing the braid through a take-up mechanism; moving the braid along a continuous path, the continuous path extending from the braiding machine, through a take-up mechanism, and at least partially through a cutting machine; and cutting the braid in the cutting machine to form a cut braid.

Delivery systems, methods and associated devices for management of an elongate element having sections with differing mechanical properties, in particular, for management of a loop of suture-wire element extending proximally from a delivery catheter for deployment of a heart implant. Such management devices can include an inner feature (e.g. outward facing groove or series of tabs) along an inner circle about which a suture can be coiled and an outer feature (e.g. inward facing groove or tabs) to engage and constrain a wire section having increased stiffness within a coil having a larger diameter than the coiled suture. Such devices can be provided separately or can be integrated within a handle of the delivery catheter. Methods of loading suture-wire management devices and utilizing such devices during deployment of an implantable anchor are also described herein.

A fistula treatment system comprises a guide such as a guide coil 1101 which is adapted to extend partially around a tissue tract and an implant element 1102. The implant element 1102 is activated to draw tissue surrounding the tract inwardly.

A method of suturing includes: (1) wrapping a first segment of a suture through a traction loop; (2) pulling the traction loop and the first segment through an opening in a suture lock; (3) continuing to pull the traction loop such that a second segment of the suture extends through the opening, wherein the second segment has a greater denier than the first segment such that the second segment more nearly fills an entire dimension of the opening than the first segment; and (4) locking the suture in place with the second segment in the opening.

An apparatus (500) for compressing a tumor in an organ of a body of a subject for increasing pressure within the tumor until causing ischemia and/or necrosis in the tumor. The apparatus includes an elongated body (501) for reaching surface of the organ via surgical access formed in the body. The apparatus includes a tightening mechanism (502) for tightening a tension member around a volumetric portion of organ and/or the tumor. The tightening mechanism includes a pulling member (504,505) and a force manipulator unit (513) for applying a tensioning force via the pulling member to force the tension member into a tightened state. The apparatus includes a securing mechanism (503) for securing first and second portions of the tension member for maintaining the tension member in the tightened state.

Methods and apparatus are provided to facilitate the minimally invasive removal of tissue and to facilitate the direct approach to anesthetizing a body wall of a patient. A pull-type cutting device also is disclosed to introduce an opening into the body wall to provide access for intra-chest surgical interventions, for example a minimally invasive biopsy technique as also described for excising target tissue from within a patient, including a nodule from within the patient's lung.