In various embodiments, a tissue thickness compensator can comprise one or more capsules and/or pockets comprising at least one medicament therein. In at least one embodiment, staples can be fired through the tissue thickness compensator to rupture the capsules. In certain embodiments, a firing member, or knife, can be advanced through the tissue thickness compensator to rupture the capsules.

Methods for forming an implantable layer onto a staple cartridge are disclosed.

A surgical system comprising an electric motor and a surgical instrument is disclosed. The surgical instrument comprises a housing, a shaft extending from the housing, a fastener cartridge, an anvil, a translatable drive member, and a rotatable actuator knob. The housing comprises an input shaft operably coupled to the electric motor. The input shaft is rotatable in a first mode by the electric motor. The fastener cartridge comprises a plurality of fasteners removably stored therein. The anvil is configured to deform the fasteners. The translatable drive member is configured to move the anvil toward and away from the fastener cartridge. The translatable drive member is movable by the electric motor in the first mode. The rotatable actuator knob is configured to be rotated multiple full rotations in a second mode to manually cause the input shaft to move the anvil.

A surgical stapler is disclosed herein. The surgical stapler comprises a body having a distal end and a proximal end, and the body defines an interior space. A first knob and a second knob are configured adjacent the proximal end of the body. An anvil and trocar assembly is configured adjacent the distal end of the surgical stapler, wherein the anvil and trocar assembly is coupled to the first knob, and the first knob is configured to facilitate the extension and retraction of the anvil and trocar assembly at the distal end of the body. A staple and knife assembly is configured adjacent the anvil and trocar assembly within the body, wherein the staple and knife assembly is coupled to the second knob, and wherein the second knob is configured to facilitate firing of staples and actuation of a knife of the staple and knife assembly sequentially.

A method for creating a flexible fastener line is disclosed. The fastener line comprises fasteners oriented in directions which are transverse or oblique to a tissue incision created by a cutting member. The fasteners can translate and/or rotate within the tissue when the tissue is stretched thereby creating flexibility within the tissue.

A surgical instrument is disclosed comprising an end effector including a first jaw and a second jaw, wherein the first jaw is rotatable relative to the second jaw, and a closure system configured to close the first jaw during a closure stroke. The surgical instrument further comprises an articulation joint rotatably connecting the end effector to the shaft, an articulation system configured to articulate the end effector relative to the shaft, and a firing system operably engaged with the electric motor, wherein the firing member is configured to move through the end effector during a firing stroke. The surgical instrument further comprises a first rotatable member configured to selectively synchronize the motion of the firing system with the motion of the articulation system and a second rotatable member operably engageable with the articulation system, wherein the closure system is configured to stop the rotation of the second rotatable member.

Surgical stapling instruments are disclosed comprising a staple cartridge, a firing member, and a cartridge lockout configured to prevent the firing member from being advanced through the staple cartridge if the staple cartridge has been already spent. The stapling instruments further comprise a lockout in the shaft that responds to the cartridge lockout blocking the firing member.

An end effector for use by a surgeon to staple an anatomical structure of a patient during a surgical procedure includes an anvil and a cartridge. Each of the anvil and the cartridge has a face that is positionable on the anatomical structure. The anvil is coupled to the cartridge at first and second ends. The anvil is movable relative to the cartridge to define a first gap between the faces at the first ends that is different from a second gap between the faces at the second ends.

A surgical staple cartridge is disclosed comprising a plurality of staples removably stored within the surgical staple cartridge. The staples comprise staple legs which extend from a staple base portion. The staple legs comprise staple tips configured to pierce tissue and contact a corresponding forming pocket of an anvil of surgical stapling instrument. The staples further comprise zones having different hardnesses.

A method is disclosed. The method can comprise obtaining a first staple cartridge and obtaining a second staple cartridge, wherein the first staple cartridge and the second staple cartridge comprise the same length and the same width. The method can further comprise inserting the first staple cartridge into a channel comprising a keyed profile, wherein complete insertion of the first staple cartridge into the channel is prevented by the keyed profile. Additionally, the method can comprise inserting the second staple cartridge into the channel, wherein complete insertion of the second staple cartridge into the channel is permitted by the keyed profile.