Medical devices, systems and methods for occluding a left atrial appendage of a heart. In one embodiment, a medical device system includes a pusher catheter with a medical device coupled adjacent a distal end of the pusher catheter. The medical device includes a primary hub and a secondary hub with a framework extending therebetween, the primary hub including grooves defined therein. The framework is moveable between constricted and expanded positions such that as the framework moves to the constricted position the grooves are configured to align portions of the framework as the secondary hub moves through the bore of the primary hub. In another embodiment, components of the framework may be configured to minimize resistance in the system as the medical device is delivered and moved between the constricted and expanded positions.

A left atrial appendage closure device may include an expandable framework having a plurality of struts joined at a proximal and distal hub. When the framework is fully constrained in a first position, a first segment of struts extends distally from the distal hub parallel to a central longitudinal axis to a first bend and a second segment of struts extends from the first bend proximally. A first amount of the framework is unconstrained in a second position, where the first segment extends distally from the distal hub parallel to the central longitudinal axis to the first bend, the second segment extends from the first bend proximally and radially outward to a second bend, a third segment of struts extends from the second bend proximally and radially inward to a third bend, and a fourth segment of struts extends from the third bend proximally to within the delivery sheath.

The disclosure includes a vein ablation system, comprising a catheter having an elongated body. In some embodiments, the vein ablation system comprises an ablation device at a distal portion of the elongated body. According to some embodiments, the vein ablation system comprises a control device at a proximal portion of the elongated body. The control device may comprise an input mechanism configured to simultaneously control at least two of a longitudinal translation of the ablation device through a target vessel, a rotation of the ablation device about a central longitudinal axis, and an infusion of a chemical agent into the target vessel.

Devices and methods for increasing a patient's pulmonary arterial compliance are disclosed. The devices include catheters designed to create a connection between a patient's venous anatomy and the patient's pulmonary artery. With the arteriovenous connection various devices can be implanted in order to increase the volumetric compliance of the pulmonary artery. The devices include collapsible and expandable mechanisms which allow the effective pulmonary arterial volume to expand during systole and contract during diastole. The devices may include a balloon or balloon-like implants which cyclically shuttle a working fluid from the pulmonary artery to the vein and back. The devices may be adjustable to provide desired hemodynamic benefits. Methods are disclosed for making and using the inventive devices.

A parent artery occlusion (PAO) device which provides for immediate occlusion of a cerebral artery to isolate a defect. The PAO device includes a self-expanding wire-frame prolate structure which is partially covered with an ePTFE membrane.

A device for treating an aneurysm with a braided implant can include a delivery tube having a spiral groove on an outer surface of the delivery tube and a braided implant having a spiral segment. The spiral segment can engage the spiral groove as the braided implant is delivered to an aneurysm treatment site. At the treatment site, the braided implant can be implanted, and the delivery tube can be rotated to disengage the spiral segment from the spiral groove. Once released, the spiral segment can reshape to occlude the neck of the aneurysm.

The invention relates to a device (17) for treatment of body tissue, in particular for the permanent occlusion of varicose veins, preferably in the lower limbs, of varicocele and/or of vascular malformations and/or for the use in aesthetic surgeries, preferably laser assisted lipolysis, and/or for tumor treatment by means of laser induced thermotherapy and/or photodynamic therapy, by means of a light diffuser (13) circumferentially and endoluminally irradiating said tissue by laser light energy, said diffuser (13) being connected at its proximal end to a source (10) of laser light energy via a flexible wave guide (12) comprising a fiber optic core (1) covered by an optical cladding (2) having a refractive index smaller than that of the core (1), wherein in the cladding (2) and/or in the core (1) imperfections (18) are provided, designed as recesses and adapted to direct the light, preferably to refract and/or reflect the light propagating within the core (1) and/or its optical cladding (2) in generally radial directions, wherein a cap (7) transparent to the laser light enclosing the distal end of the core (1) and its optical cladding (2) in a fluid tight and/or liquid tight manner is provided. According to the invention the device (17) is characterized in that the outer surface (19) of said optical cladding (2) is fused in the region (A) between said imperfections (18) to the inner surface (21), preferably the inner diameter, of the cap (7) and/or in that the outer surface (19) of said optical cladding (2) extending over a distance in front and/or behind the region (A) provided with the imperfections (18) is fused to the inner surface (21), preferably the inner diameter, of the cap (7).

A left atrial appendage occluder for improving sealing effect and a manufacturing method thereof are provided. The left atrial appendage occluder includes a sealing portion and an anchoring portion coupled to the sealing portion. The sealing portion and the anchoring portion abut against each other. A tight connection between the sealing portion and the anchoring portion can be achieved by applying a pre-tightening force, such that the left atrial appendage occluder can be better attached to and occlude the left atrial appendage after being release.

An implant for occluding a left atrial appendage may include an expandable framework including a body portion and a disk portion, wherein the expandable framework is configured to shift between a collapsed configuration and an expanded configuration, and an occlusive disk element disposed within the disk portion. The disk portion may include a first disk portion integrally formed with the body portion, and a second disk portion movably attached to the first disk portion by at least one hinge member.

The invention relates to a novel multivalent atrial appendage occluder of hybrid design based on two different atrial appendage occluders, one having a proximal disk-shaped cover and a second version without a proximal cover. The two occluder variants each provide relevant application solutions by themselves. The invention further relates to multiple specified, universal devices composed of predominantly rotationally symmetrical individual parts for producing these different LAA occluders (LAA=Left Atrial Appendage) which are graded in different sizes, for the interventional, catheter-based closure of the left atrial appendage. Axially and radially oriented hooks support the secure and gentle anchoring of the occluders 1 in the retaining area of the atrial appendage 26. As a result, the use of substantially smaller access ports in the interventional application is possible. The two atrial appendage occluder variants, with and without proximal cover 14, can be inserted using the same controllable access port and can be implanted in various sizes individually or in combination with one another and likewise as a hybrid variant of two occluders, one without a proximal cover (14) and one subsequently with a proximal cover (14) in one and the same atrial appendage (24) as shown in FIG. 17. The two atrial appendage occluder variants can each be released during the implantation phase in three stages until they are fully unfolded.