Intrasaccular devices and methods of implanting the devices in an aneurysm are described. The device includes an expandable body comprising a plurality of elongate filamentary elements each having a first and a second end. Each of the plurality of elongate filamentary elements extends from a first end of the device to a second end of the device and back to the first end of the device. The first and second ends of each of the plurality of elongate members are coupled at the first end of the device in a hub. The device may further include a defect spanning structure made of a mesh. The defect spanning structure may be located around a proximal portion of the expandable body, and may be disposed exteriorly to an outer surface of the expandable body

An example medical device for occluding the left atrial appendage is disclosed. The example medical device for occluding the left atrial appendage includes an expandable member having a first end region and a second end region. The expandable member comprises at least one inflation cavity and at least one valve member configured to selectively seal the inflation cavity. A first inflation media may be disposed within the at least one inflation cavity and a second inflation media may be disposed within the at least one inflation cavity. The second inflation media may be different from the first inflation media. The expandable member may be configured to expand and seal the opening of the left atrial appendage.

The present subject matter provides a system for temporarily stopping blood flow through a blood vessel, the system including: at least one magnetically attractive element configured to be introduced into an internal part of a body of a patient, and temporarily placed near a first blood vessel that supplies blood to at least one second blood vessel; and at least one magnetic field generator configured to be placed outside a body of the patient, and generate a magnetic field that attracts the at least one magnetically attractive element in a manner that the at least one magnetically attractive element presses the first blood vessel, thereby stopping flow of blood through the first blood vessel toward the second blood vessel. Additional embodiments of the system, of a kit comprising components of the same, and a method for temporarily stopping blood flow through a blood vessel, are disclosed herein as well.

Systems and methods for the treatment or prevention of dysbiosis in the gastrointestinal tract of an individual and includes implantable devices adapted to release therapeutic or restorative microbiota to an individual's GI tract as well as ablation systems that can ablate residing microbiota before administering the restorative microbiota.

An occlusion device for implantation in a left atrial appendage includes a proximal hub defining a recess configured to releasably connect with a delivery shaft, a frame connected to the proximal hub, a membrane coupled to and covering at least the proximal portion of the frame, the membrane comprising a material configured to block a passage of blood clots therethrough, and a plug configured to be received in the recess and remain in the recess after implantation.

An occlusion device intended for blocking perivalvular leak channels that are found following heart valve implantation between the heart valve and the surrounding tissue. The occlusion device has a stent and a covering that is attached to the stent surface. A blocking fabric extends across the lumen of the stent to block blood flow. The stent pattern and wall structure provide for small radius of curvature bends to fill narrow channels that cause the perivalvular leaks.

The present disclosure is related to an occlusion device having a mesh structure. The occlusion device configured to transition between a two-dimensional configuration and a three-dimensional configuration. In the two-dimensional configuration and at rest, the occlusion device is flat or planar. In the three-dimensional configuration, the occlusion device defines an internal volume.

Treatment of an aneurysm or other vascular defect can be facilitated or enhanced by an implant delivered with a thermally activated detachment system. A delivery system can include an implant with a proximal portion that defines a port. A pusher device can include arms extending distally from a junction of the pusher device and through the port, with distal sections of the arms disposed within the implant. The arms can, at a certain temperature, transition from engagement with the implant to a shape that facilitates release of the implant. Additionally or alternatively, a coil can engage an outer surface of the implant at the proximal portion and transition to a shape that facilitates release of the implant.

Devices, systems, and methods used to seal a treatment area to prevent embolic agents from migrating are described. The concept has particular benefit in allowing liquid embolic to be used with a variety of intravascular therapeutic applications, including for occluding aneurysms and arteriovenous malformations in the neurovasculature.

Detachment of an implant from a delivery assembly can be electrolytic and provide an electrical current pathway through a fluid within a portion of a delivery system containing the delivery assembly. After the implant is located at a target location within a patient, a voltage potential is applied between (i) a delivery electrode electrically connected to an electrolytic detachment zone and (ii) an infusion electrode disposed outside of the patient and electrically connected to the electrolytic detachment zone via a fluid from a fluid source disposed outside of the patient. While applying the voltage potential, the fluid can be flushed from the fluid source past the detachment zone.