The invention provides intravascular devices for treating certain medical conditions such as edema without causing thrombosis. The intravascular devices of the disclosure include non-thrombogenic surfaces that improve blood compatibility by reducing device-related thrombus formation and inflammatory reactions. The non-thrombogenic surfaces may include surface topographies (e.g., surface roughness) and modified chemistries (e.g., coatings and/or treatments), which prevent thrombosis by reducing local shear forces and inhibiting adhesion of blood clotting factors.

Various aspects of the present disclosure are directed toward apparatuses, systems and methods that include arranging an acute alteration of blood flow in, for example, heart failure patients.

Methods and devices for improving airflow distribution in treatment of respiratory conditions are disclosed. According to various embodiments, blocking devices may be used to redirect air away from healthy portions of the lung to diseased portions so that inhaled medication may be more effectively delivered to the patient.

A new medical apparatus for deployment within an anatomical blood vessel and methods of use thereof. The apparatus comprising: a first tubular wall; and a second tubular wall, placed within the first tubular wall; wherein the first and second tubular walls are firmly connected at their edges, therefore restricted to have same overall longitudinal length; and wherein the second tubular wall is configured to be partially constricted towards its inner radial axis, while maintaining its overall longitudinal length.

A pulmonary artery flow restrictor system includes a funnel shaped membrane with a proximal base and a restrictive distal opening which is stretchable to larger sizes. A self-expanding frame is attached to the proximal base of the membrane for securing the membrane within the pulmonary artery.

Medical devices and methods for occluding fluid flow in a blood vessel, and specifically for embolizing vessels concentrically, are provided. In an embodiment, the medical devices comprise a proximal end, a distal end, an elongated member positioned between the proximal end and the distal end, wherein the elongated member has a lumen passing through, and a flow-limiting member coupled to the distal end.

Left atrial appendage (LAA) occlusion device including a membrane, a plurality of fixation splines and a deployment hub, the plurality of fixation splines for affixing the LAA occlusion device to an ostium of the LAA, the deployment hub being positioned in the membrane, the deployment hub including a threaded aperture and a one-way valve, for enabling a toxin to be entered into the LAA through the deployment hub.

The method of delivering an implant in an intracranial vessel includes deploying an anchor of a tethering device in an anchoring vessel forming a first fixation point and advancing a guide-sheath to a location near the anchoring vessel. The tethering device has a tether extending proximally from the anchor and the guide-sheath has at least one lumen. The method includes attaching the guide-sheath to the tether of the tethering device forming a second fixation point proximal to the first fixation point, delivering an implant through the lumen of the guide-sheath towards a treatment site distal to the first fixation point and located within an intracranial vessel, and deploying the implant at the treatment site. Related devices, systems, and methods are also provided.

The present disclosure concerns embodiments of an implantable perfusion device that can be implanted in an injured blood vessel to control bleeding without occluding the vessel. In one specific implementation, the perfusion device can be implanted percutaneously into a patient's descending aorta to control bleeding at the site of a ruptured portion of the aorta (known as torso hemorrhage) while still allowing for the antegrade flow of blood from a location upstream of the ruptured portion of the aorta to a location downstream of the ruptured portion of the aorta. The perfusion device can be left inside the patient as the patient is transported to a medical facility where the injury can be repaired. Following repair of the vessel, the perfusion device can be withdrawn from the patient.

The present invention relates to a nasal plug for diverting airflow from a natural flow path in a person's nostril. In some circumstances, the airflow is channeled and directed to a specific location in a person's nasal or sinus cavity. The person may adjust and self-select a preferred airflow path by adjusting the nasal plug's location in the nostril, e.g., rotating the plugs. A kit may include two plugs, which may be used singly or in combination with each other and are independently adjustable/rotatable. A method for reducing nasal discomfort or improving nasal functions by diverting channeled airflow in a nostril is also disclosed.