Disclosed herein are various exemplary systems, devices, and methods for inhibiting premature implant deployment. The delivery member can include a body including a lumen extending therethrough, the body including a compressed distal portion. The delivery member can include a pull wire extending through the lumen. The pull wire can include a pull wire portion that extends radially to abut a sidewall of the body to provide frictional resistance against the body. The pull wire can be positioned to secure the implantable medical device to the delivery member, and the pull wire portion can be effective to inhibit premature detachment of the implant by inhibiting proximal translation of the pull wire due to the frictional resistance provided by the pull wire portion against the body.

Delivery and detachment system for an implantable intravascular device, the system including a securement wire in a passageway of an inner support tube. Imposed on the securement wire is a controlled friction force established within an intentional friction zone created by: (i) reflow of an outer sleeve through side port opening(s) in the inner support tube and into the passageway; or (ii) the securement wire having bend(s) creating an associated point(s) of direct physical contact with the inner wall of the inner support tube. During delivery of the implantable intravascular treatment device to a target site, the imposed controlled friction force minimizing movement of the securement wire relative to the inner support tube, and upon reaching the target site, a force being applied to overcome the imparted controlled friction force and releasing the implantable intravascular device.

A device for regulating blood pressure between a patient's left atrium and right atrium, and apparatus for delivery the device, are provided. The delivery apparatus may include one or more latching legs, a release ring, a pull chord, and a catheter wherein the latching legs are configured to engage the device for delivery. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices may be used, for example, to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.

System for inserting a self-expandable occluder (12) into a patient and for releasing the occluder (12) in the left atrial appendage (10) of the patient, the system including an insertion unit (100) which has a drive unit (102) and an insertion catheter including an outer tube and an inner tube extending through the outer tube, wherein a proximal end region of the occluder is movement-coupled to the outer tube, and wherein a distal end region of the occluder, is movement-coupled to the inner tube, wherein, in order to release the occluder, the drive unit interacts with the inner tube and the outer tube such that, when actuated, the inner tube can be moved in a distal or proximal direction and the outer tube can be moved in the proximal direction or distal direction, so that the distal end and the proximal end of the occluder can be moved away from or toward one another.

Devices, methods and systems are provided for occluding an opening within the tissue of a body, such as a left atrial appendage. In one embodiment, a medical device coupled to a delivery catheter includes a fluid flow path that facilitates contrast fluid to pass through the delivery catheter and the medical device to a distal side thereof to provide imaging information as to the position of the medical device positioned in the opening, such as the left atrial appendage. In another embodiment, a medical device is coupled to a delivery catheter, the medical device including flaps adjacent a hub of the medical device that close-off a bore of the hub upon the catheter being detached from the medical device.

An implant for occluding a left atrial appendage may include an expandable framework including a body portion and a disk portion, wherein the expandable framework is configured to shift between a collapsed configuration and an expanded configuration, and an occlusive disk element disposed within the disk portion. The disk portion may include a first disk portion integrally formed with the body portion, and a second disk portion movably attached to the first disk portion by at least one hinge member.

Devices and methods for treating vascular defects, such as, for example, balloon-type aneurysms, are described herein. In one embodiment, an apparatus includes an insertion portion and an expandable implant. The expandable implant is configured to be deployed in an aneurysm and is coupled to the insertion portion. The expandable implant has a first portion and a second portion coupled to the first portion. The expandable implant is movable between a first configuration in which the first portion and the second portion are substantially linearly aligned and a second configuration in which the second portion at least partially overlaps the first portion.

A medical instrument (1000) includes a stent (100) and a constraining structure (300). The constraining structure (300) constrains, and thereby prevents tangling of, a trailing section of the stent (100), ensuring successful release of the stent (100). Specifically, the stent (100) has a first proximal end and an opposing first distal end. The first distal end is configured with an expanded configuration and a collapsed configuration. The trailing section at the first distal end includes a number of protrusions (111). The constraining structure (300) includes a body (310) and a clamping mechanism (320). The clamping mechanism (320) is disposed at a distal end of the body (310), and the body (310) extends from the first proximal end to the first distal end. The clamping mechanism (320) limits relative movement and thus prevents tangling of the protrusions (111) by passing through all or some of the protrusions (111). Additionally, it allows the stent (100) to be less deformed within a delivery sheath and thereby enables it to successfully expand when pushed out of the sheath.

The present invention describes systems and methods for treating a hole in the septum, such as a patent foramen ovale or an atrial septal defect, with a closure implant designed to fluidly seal the hole to prevent blood from flowing between the right atrium to the left atrium. The closure implant includes two structures positioned on opposite sides of the hole in septum configured to close and seal the hole. The first structure is an expandable petal anchor having multiple petal groups with multiple petals of different sizes and/or shapes made of shape memory wire configured to be positioned on a distal side of the hole in the septum wall, and the second structure is a braided disk made of shape memory mesh positioned the proximal side of the hole in the septum wall, opposite the petal anchor. The braided disk is sized to cover the hole once it is expanded. The petal anchor is designed to pull and compress the braided disk against the septum wall to cover and fluidly seal the hole. The closure implant is designed to be delivered to the heart using a catheter-based delivery system.

The present invention describes systems and methods for treating the left atrial appendage with an implant to fluidly seal the left atrial appendage and prevent blood from flowing from the left atrial appendage to the left atrium. The closure implant includes a braided disk, a proximal petal anchor and a distal petal anchor positioned on an implant shaft. The braided disk includes two diameters: a proximal diameter sized to engage a wall area in the left atrium around the LAA ostium; and a distal diameter sized to fit within the LAA ostium. The proximal and distal petal anchors include asymmetrical petals arranged like the petals of a flower configured to engage the wall of the LAA to anchor the implant. The implant is designed to be delivered to the heart using a catheter-based delivery system.