A device and method for injecting liquid embolic agents utilizing a plug and push technique. The device/catheter has at least one side hole or an externally swellable region which creates a plug upstream of the distalmost portion of the catheter and thereby ameliorates the suboptimal outcomes associated with creating a plug upstream of a distal end hole via injecting embolic agents only at the distalmost portion of the catheter. The catheter can include a flow restricting structure to initially block flow of the liquid embolic agent out the distal end hole and direct flow of the liquid embolic agent through the one or more side holes.

Blood loss during surgery is inevitable. Currently, clamps may be used to try and stop the bleeding of blood vessels. However, some blood vessels cannot be adequately clamped and therefore are left to leak blood which is then sponged off. The present invention features devices and methods for occluding vascular vessels during surgery to help prevent blood loss. Specifically, the present invention features a device (i.e., a plug) that, when inserted into the vessel lumen of the vascular vessel, prevents blood flow by exerting a radial force on the vessel. The small and versatile plugs described herein help reduce blood loss during surgery and can work on all sizes of blood vessels.

Devices and methods are described for occluding the left atrial appendage (LAA) to exclude the LAA from blood flow to prevent blood from clotting within the LAA and subsequently embolizing, particularly in patients with atrial fibrillation. An implant is delivered via transcatheter delivery into the LAA. The implant includes a conformable structure comprising a foam body and internal support. The support includes anchors that penetrate the foam body and anchor the implant to the walls of the LAA. The implant provides compliance such that it conforms to the native configuration of the LAA.

An occlusive medical device system may include an elongate shaft having a distal strain relief portion and a lumen extending longitudinally through the elongate shaft, the elongate shaft including a plurality of retaining arms extending distally from the distal strain relief portion; an occlusive medical device including a proximal mounting portion fixed to an expandable occlusive element; and a release wire disposed within the lumen of the elongate shaft. The plurality of retaining arms may extend into the proximal mounting portion. The release wire may be configured to engage the plurality of retaining arms in a distal engagement position, thereby urging the plurality of retaining arms radially outward into releasable engagement with the proximal mounting portion. When the release wire is in a proximal released position, the plurality of retaining arms is deflectable radially inward to disengage from the proximal mounting portion.

A method for treatment of chronic obstructive pulmonary disease includes occluding at least one of a bronchial tube and emphysema, and deciding whether or not a bypass has been formed by the occlusion.

Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.

Micro-catheters and embolic agents offer better results in endovascular treatment of brain arteriovenous malformations. Using said micro-catheters and embolic agents generally requires the creating of a plug at the distal-most portion of said micro-catheters which regularly results in suboptimal results. The present invention teaches how to create and use a device which creates a plug downstream of the distal-most portion of said micro-catheters and thereby ameliorates the suboptimal outcomes associated with creating a plug at the distal-most portion of said micro-catheters.

Methods and devices are provided for anastomosing tissue in the body. In one exemplary embodiment, an anastomotic device is provided having an elongate tubular body that is disposable through a body lumen and that includes proximal and distal portions. The proximal and distal portions can each include a plurality of asymmetrical s-shaped slits and can each be adapted to expand upon rotation to form proximal and distal wings. The proximal and distal wings can extend toward one another to engage tissue therebetween and thereby form a passageway through the tissue.

A medical system includes a porous body positioned at a target site within a subject, a tube including a wall defining a tube lumen, where the tube is connected to the porous body at a first end of the tube, and a sealing device to seal the target site from a body lumen. When the sealing device seals the target site from the body lumen, the tube extends from the target site into the body lumen.

Embodiments of the present disclosure comprise occlusion and drug delivery devices and methods. One aspect of the disclosure comprises a drug delivery device comprising an inner expansion member and an outer drug delivery component. Another aspect of the disclosure comprises bioabsorbable, lumen-occluding implants.