The present disclosure is directed to methods of treating subject patients (such as humans, animals, plants) suffering from a pathogenic disease such as COVID-19 in humans, via the administration of pressure changes in the patient sufficient to cause a pressure differential to be created between the inside and outside of the outer membrane or envelope of the pathogen thereby destroying or disabling the pathogen. In one embodiment, a hyperbaric chamber is used to administer pressure increases and/or pressure decreases to create such pressure differential. The hyperbaric chamber could comprise a single user or multi-user unit, a pressurized body suit, or the pressurizable fuselage of an aircraft. In another embodiment, patients are placed in an aircraft, and the cabin pressure, while on the ground, or in flight, is adjusted upwardly or downwardly to create such pressure differential. The pressure differential methods can also include the use of external gases to enter the patient's body and/or lungs to facilitate disruption of the pathogen outer membrane as well as application of variations in temperature and/or humidity. A mobile treatment unit is also disclosed. Also disclosed are methods of using ultrasonic cavitation or MRI (or other sonic or magnetic field forces sufficient to disrupt the functionality of the pathogen), or a combination of ultrasound and MRI on the exterior of a patient in a desired anatomical region of the patient to assist with the destruction or disabling of a pathogen infecting that anatomical region of the patient, e.g., the patient's lungs, said method being employed at ambient pressures or in an increased or decreased pressure environment created within a hyperbaric chamber. The ultrasound and/or MRI methodologies could also be used to treat other pathogenically afflicted areas of the patient's body. Additionally, a pressure-differential method of sterilization of medical equipment is disclosed employing a hyperbaric or other pressure or vacuum chamber. Also disclosed is an enhanced method of nonsurgical fat reduction in humans by employing ultrasonic cavitation within a hyperbaric chamber, including the use of HBOT therapies. Furthermore, the use of these methodologies and systems have application in treatment of patients post-infection and in other areas of medicine and health, such as for example, treating wounds, the effects of aging, inflammation, and the effects of other maladies.

This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

A kit comprising: a urinary catheter comprising a first and a second longitudinal lumens; an ultrasonic transducer disposed about said catheter; a balloon mounted on said catheter, and enclosing said transducer; and a reservoir containing an acoustic coupling medium, wherein: said catheter further comprises a first opening in said first longitudinal lumen, said first opening disposed inside said balloon and configured to inflate said balloon with at least some of said acoustic coupling medium, said catheter further comprises a second opening in said second longitudinal lumen, said second opening disposed outside said balloon and configured to deliver a therapeutic fluid into the urinary bladder, around said balloon, and activation of said transducer in said urinary bladder causes cavitation bubbles to form in said therapeutic fluid adjacent an internal surface of the urinary bladder, and little or no cavitation bubbles are formed in said acoustic coupling medium in said balloon.

The present disclosure relates generally to thrombectomy devices. An exemplary catheter comprises: an emitter assembly comprising at least one emitter; wherein each emitter comprises an electrode pair, and wherein each emitter is configured to generate a plurality of cavitation bubbles when a voltage is applied to the pair of electrodes; an infusion lumen formed by at least a portion of an outer wall of the catheter, the infusion lumen configured to receive a conductive fluid, wherein the emitter assembly is housed within the infusion lumen, wherein a distal segment of the infusion lumen includes a plurality of holes on the portion of the outer wall of the catheter, and wherein the plurality of holes are configured to release the conductive fluid and the plurality of cavitation bubbles out of the catheter to treat thrombus at a treatment site; an aspiration lumen including aspiration ports at the distal segment thereof.

Various approaches to focusing an ultrasound transducer includes causing the ultrasound transducer to transmit ultrasound waves to the target region; causing the detection system to indirectly measure the focusing properties; and based at least in part on the indirectly measured focusing properties, adjusting a parameter value associated with at least one of the transducer elements so as to achieve a target treatment power at the target region.

A guidewire includes an elongated member and a shaft extending distally from the elongated member, wherein the elongated member and shaft are configured to be navigated through vasculature of a patient. The guidewire further includes a first conductor extending around the shaft to define an outer perimeter of the guidewire and a first electrode adjacent the shaft. The first conductor is configured electrically connect the first electrode to an energy source. The guidewire further includes a second electrode and a second conductor configured to electrically couple the second electrode to the energy source. The first and second electrodes may be configured to deliver an electrical signal to fluid contacting the first and second electrodes to cause the fluid to undergo cavitation to generate a pressure pulse wave within the fluid.

This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

Various approaches to generating and maintaining an ultrasound focus at a target region include configuring a controller to cause transmission of treatment ultrasound pulses from a transducer having multiple transducer elements; cause the transducer to transmit focusing ultrasound pulses to the target region and generate an acoustic reflector therein; measure reflections of the focusing ultrasound pulses from the acoustic reflector; based at least in part on the measured reflections, adjust a parameter value associated with one or more transducer elements so as to maintain and/or improve the ultrasound focus at the target region.

A method for displaying a passive cavitation image that shows characteristic information of a passive cavitation includes: receiving an ultrasound signal caused by the passive cavitation; generating a plurality of first passive cavitation images for the passive cavitation at predetermined respective time frame using the received ultrasound signal by a DAS beam forming; generating a plurality of second passive cavitation images in which a maximum magnitude signal region is displayed by selecting a main lobe region having a magnitude greater than or equal to a predetermined value in the respective first passive cavitation image; generating a main lobe passive cavitation image in which a main region is displayed in the respective time frame by superimposing the plurality of the second passive cavitation images obtained for the respective time frame; and generating a passive cavitation image by displaying the main lobe passive cavitation image on a background image.

A wireless magnetic ultrasonic cavitation in-vivo therapeutic robotic device, including a micro-robot and an in-vitro control device; the in-vitro control device has an outer housing in which provided with electromagnetic coils and wireless power emitting coils; the micro-robot has a capsule shaped housing in which a super magnetic module is provided; a micro ultrasonic vibrator and a micro wireless power receiving coil electronically connected with each other are provided inside the housing; the wireless power emitting coils emit electromagnetic field to the micro wireless power receiving coil, which receives and then transforms the electromagnetic field to electrical current to supply power to the micro ultrasonic vibrator. The robotic device creates ultrasonic cavitation effect in the blood, causing rapid vibration of blood cells, which enhances cell regeneration power, burn blood lipids, clear blood clots and ensures good condition of blood vessels.