The present disclosure relates generally to thrombectomy devices. An exemplary catheter comprises: a central tube; an emitter assembly mounted over the central tube, wherein the emitter assembly comprises: a conductive sheath; a first insulated wire having a first curved distal portion; and a second insulated wire having a second curved distal portion, wherein the first curved distal portion and the second curved distal portion are positioned within the conductive sheath, and wherein the emitter assembly is configured to generate a plurality of cavitation bubbles or shockwaves when a pulsed voltage is applied to the emitter assembly; and an outer tube housing the emitter assembly, wherein the outer tube is configured to receive a conductive fluid, wherein the outer tube comprises a distal opening for releasing the plurality of cavitation bubbles or shockwaves and the conductive fluid in a forward direction to treat thrombus at a treatment site.

This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

A method of treating a mobile target tissue with a laser beam includes: providing a laser device for generating a laser beam and providing an optical fiber having a delivery end for guiding the laser beam to the target tissue; a controller causes the laser device to generate one or more laser pulses substantially along the same longitudinal axis. The controller causes the laser device to provide one or more laser pulses. The one or more pulses are selected to allow a vapor bubble formed by the one or more pulse to expand an amount sufficient to displace a substantial portion of the liquid medium from the space between the delivery end of the fiber and the target tissue. The one or more pulses are delivered to the target tissue through the vapor bubble after the vapor bubble has reached its maximum extent and has begun to collapse to reduce retropulsion of the mobile target tissue.

Method and system for localizing a region of interest in a medium in which cavitation occurs. Method for localizing a region of interest (R) in a medium (M) in which cavitation occurs, the method comprising the steps consisting in: producing cavitation in the region of interest (R), the cavitation generating an acoustic signal, at each of at least three separate positions, detecting a cavitation signal representative of the acoustic signal of the cavitation, for at least two pairs of cavitation signals, determining a delay between the cavitation signals of each pair of cavitation signals, calculating a localization of the region of interest (R) based on the delays and the positions.

Various approaches to generating and maintaining an ultrasound focus at a target region include configuring a controller to cause transmission of treatment ultrasound pulses from a transducer having multiple transducer elements; cause the transducer to transmit focusing ultrasound pulses to the target region and generate an acoustic reflector therein; measure reflections of the focusing ultrasound pulses from the acoustic reflector; based at least in part on the measured reflections, adjust a parameter value associated with one or more transducer elements so as to maintain and/or improve the ultrasound focus at the target region.

A method for controlling an energy treatment system includes performing treatment on a subject by a probe of an energy treatment instrument which outputs ultrasonic energy and high frequency energy in combination; setting an output reduction control period, based on information related to an amount of mist generated by the probe; and reducing the output of the high frequency energy during the output reduction control period when a precursor of occurrence of spark or occurrence of spark is detected.

A method of treating a mobile target tissue with a laser beam includes: providing a laser device for generating a laser beam and providing an optical fiber having a delivery end for guiding the laser beam to the target tissue; a controller causes the laser device to generate one or more laser pulses substantially along the same longitudinal axis. The controller causes the laser device to provide one or more laser pulses. The one or more pulses are selected to allow a vapor bubble formed by the one or more pulse to expand an amount sufficient to displace a substantial portion of the liquid medium from the space between the delivery end of the fiber and the target tissue. The one or more pulses are delivered to the target tissue through the vapor bubble after the vapor bubble has reached its maximum extent and has begun to collapse to reduce retropulsion of the mobile target tissue.

This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

The present disclosure relates generally to thrombectomy devices. An exemplary catheter comprises: a central tube; an emitter assembly mounted over the central tube, wherein the emitter assembly comprises: a conductive sheath; a first insulated wire having a first curved distal portion; and a second insulated wire having a second curved distal portion, wherein the first curved distal portion and the second curved distal portion are positioned within the conductive sheath, and wherein the emitter assembly is configured to generate a plurality of cavitation bubbles or shockwaves when a pulsed voltage is applied to the emitter assembly; and an outer tube housing the emitter assembly, wherein the outer tube is configured to receive a conductive fluid, wherein the outer tube comprises a distal opening for releasing the plurality of cavitation bubbles or shockwaves and the conductive fluid in a forward direction to treat thrombus at a treatment site.

This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.