A multi-pillar piezoelectric stack (MPPS) ultrasound transducer includes N pillars, each formed of a stack of M piezoelectric elements, N and M being integers of at least two. The ultrasound transducer further includes a bonding layer between each pair of the M piezoelectric elements. The pillars are laterally spaced from each other to form an inter-pillar gap. The transducer further includes at least one electrical interconnect for connecting the ultrasound transducer to a signal source. Through the MPPS design, the therapeutic range and the transducer sensitivity are increased over the conventional single pillar piezoelectric stack (SPPS) transducer design.

Ablation apparatus such as a catheter carrying an ultrasonic ablation device including an ablation transducer and a balloon reflector structure for directing ultrasonic energy from the ablation transducer into a ring-like ablation region is provided with an imaging ultrasonic transducer mounted on an imaging probe which may be inserted into or through a passageway extending through the catheter and into or through the ablation device to image the ablation region or neighboring regions. Alternatively, the imaging transducer may be mounted within the balloon reflector structure or distal to this structure.

A cardiac ablation method including the following steps: inserting a treatment catheter into an atrium of a heart, the treatment catheter including an ultrasound emitter; positioning the ultrasound emitter to face heart tissue within the left atrium outside of a pulmonary vein; emitting ultrasound energy from the ultrasound emitter while rotating the ultrasound emitter about a rotation axis; and ablating heart tissue with the ultrasound energy to form a lesion outside of a pulmonary vein.

A shock wave treatment device to treat skin and adjacent tissue with a combination of mechanical stimulation and acoustic pressure shock waves, such as methods for cosmetic applications, enhancing blood circulation, and wound treatment, includes a pressure shock wave applicator having a reflector and a mechanical stimulator of one or both of a vacuum device and roller device.

Acoustic pressure shock waves are applied to a drug delivery structure implanted in tissue of a human or animal body and including one or more pouches that contain at least one drug in fluid form that is releasable from the drug delivery structure when targeted by the acoustic pressure shock waves.

A system for breaking obstructions in body lumens includes a catheter including an elongated carrier, a balloon about the carrier in sealed relation thereto, the balloon being arranged to receive a fluid therein that inflates the balloon, and an arc generator including at least one electrode within the balloon that forms a mechanical shock wave within the balloon. The system further includes a power source that provides electrical energy to the arc generator.

An extracorporeal pressure shock wave device includes a hinge providing a pivotable axis about which a shock wave applicator rotates to provide for adjusting the depth within a targeted body that a shock wave focal volume is produced from the applicator.

Apparatuses and methods for electrohydraulic generation of shockwaves at a rate of between 10 Hz and 5 MHz, and/or that permit a user to view a region of a patient comprising target cells during application of generated shockwaves to the region. Methods of applying electro-hydraulically generated shockwaves to target tissues (e.g., for reducing the appearance of tattoos, treatment or reduction of certain conditions and/or maladies).

A lithotripter is provided that includes a lithotripsy apparatus for treatment of a urinary tract stone by fragmentation. The lithotripsy apparatus includes a lithotripsy wave guide shaft configured to transmit an energy form to at least one urinary tract stone. The lithotripter includes a sensing device configured to provide signal data for determining optimal application of energy during treatment with the lithotripsy apparatus. The lithotripter includes a processor configured to collect the signal data and provide feedback to a user. The processor has a control logic configured to determine at least one of: a) if the lithotripsy wave guide shaft is in contact with a tissue; b) if the lithotripsy wave guide shaft is in contact with a stone; c) type of stone; d) if a user is applying force in excess of a predetermined threshold; and e) physical characteristics of a stone. A method is also provided.

A method for using metastable perfluorocarbon nanodroplets for ultrasonic lysis of blood clots includes administering metastable perfluorocarbon nanodroplets into a blood vessel that includes or that leads to a blood vessel that includes a blood clot, the metastable perfluorocarbon nanodroplets each have a liquid core comprising a perfluorocarbon material that has a boiling point below 25 C. at atmospheric pressure and that remains stable in liquid form at 25 C. at atmospheric pressure. The method further includes applying ultrasound energy to the perfluorocarbon nanodroplets within or surrounding the blood clot, causing the perfluorocarbon nanodroplets to vaporize and convert to bubbles, which cavitate and lyse the blood clot.