Electrohydraulic lithotripters comprising a plurality of electrohydraulic probes are disclosed. Each probe of the plurality of probes comprise a first electrode and a second electrode positioned at a distal end of the probe such that when the probe is discharged, an electric arc between the first electrode and the second electrode produces a shockwave that radiates from the distal end of the probe. A first probe and a second probe of the plurality of probes may be configured to discharge simultaneously or sequentially.

The present invention relates to a system for the controlled fragmentation of solids by means of acoustic beams, comprising at least one acoustic beam generation unit (100); and one feedback and control unit (200) of said generation unit (100). Advantageously, the acoustic beams generated by the system are acoustic vortex beams; and the feedback and control unit (200) further comprises a feedback subsystem (12), configured to receive the information relating to the fragmented solids and to utilize it so as to adapt the operation of the acoustic beam generation unit (100). Given that the generation of shearing stresses is more efficient using vortex beams, the amplitudes of the ultrasonic field needed to fragment the calculi are much lower than in current extracorporeal shock wave lithotripsy techniques. Likewise, the system minimizes unwanted effects on soft tissues surrounding the solid.

A catheter for treating a lesion in a body lumen includes an elongate member, an enclosure, and shock wave emitters enclosed by the enclosure. At least one of the shock wave emitters has a different size than at least one of the other emitters. Providing a smaller shock wave emitter at a distal end of the catheter can help make the catheter more navigable through the body lumen.

A catheter-implemented transducer device for intravascular thrombolysis, is described herein. Such a transducer device includes a catheter defining a longitudinal axis and having opposed proximal and distal ends. At least one ultrasonic transducer arrangement is disposed about the distal end. The ultrasonic transducer arrangement is oriented with acoustic waves propagating parallel or perpendicular to the longitudinal axis. Optionally, the ultrasonic transducer arrangement is configured as a multi-layer stacked structure of ultrasonic transducer elements. Optionally, the ultrasonic transducer arrangement is a laser ultrasonic transducer arrangement. Optionally, the ultrasonic transducer arrangement is configured to operate in a lateral mode.

Described herein is a shock wave device for the treatment of vascular occlusions. The shock wave device includes an outer covering and an inner member inner connected at a distal end of the device. First and second conductive wires extend along the length of the device within the volume between the outer covering and the inner member. A conductive emitter band circumscribes the ends of the first and second wires to form a first spark gap between the end of the first wire and the emitter band and a second spark gap between the end of the second wire and the emitter band. When the volume is filled with conductive fluid and a high voltage pulse is applied across the first and second wires, first and second shock waves can be initiated from the first and second spark gaps.

A catheter includes a catheter body; at least one shock wave emitter disposed on the catheter body; and a moveable shield extending at least partially around the catheter body and configured for translating along the catheter body. Exemplary catheters are configured to modify lesions, including fibrotic and calcified tissue buildup within the body.

The present invention relates to vortex ultrasound transducers and methods of therapeutic ultrasound treatment. A device for therapeutic ultrasound treatment includes a jacket for insertion within a blood vessel of a patient and an ultrasound transducer located within the jacket and comprising a plurality of active elements that are arranged such that, when activated, the ultrasound transducer is configured to generate ultrasound energy with a swirling movement that produces a mechanical shear stress over a target area within the blood vessel of the patient.

A shock wave generator comprising a base, a plurality of transducers positioned on the base, a control assembly electrically coupled to the plurality of transducers, and a first chamber with a first fluid. The first chamber is at least partially defined by the base. The shock wave generator further comprises a second chamber with a second fluid, a membrane positioned between the first chamber and the second chamber, and a circulation assembly fluidly coupled to the first chamber. The circulation assembly includes a pump that circulates the first fluid, a chiller that controls the temperature of the first fluid, and a degasser that removes bubbles from the first fluid.

Disclosed herein are the systems, devices and methods for treating cancer and metastasis using low energy immune priming. The low energy immune priming includes administering immunopriming energy. The low energy immune priming can be combined with an adjunct therapy.

Shock wave catheters and methods of use thereof are disclosed herein for intravascular lithotripsy (IVL) and intravascular imaging of a body lumen. The shock wave catheter can include an elongate tube; at least one shock wave emitter disposed at a distal portion of the elongate tube and configured to emit shock waves for treating an occlusion in a body lumen; at least one sensor for imaging the body lumen, the at least imaging sensor disposed at the distal portion of the elongate tube; and at least one enclosure enclosing the at least one shock wave emitter and the at least one sensor. The at least one sensor may be an ultrasound transducer for intravascular ultrasound (IVUS) imaging of the body lumen. Alternatively, the at least one sensor may be an optical coherence tomography (OCT) sensor for OCT imaging of the body lumen.