An intravascular device and related methods are disclosed. In an exemplary embodiment, the device includes an expandable portion, which includes struts selectively movable between a first position and a second position where the struts are moved outward. Tissue modification element(s) are each provided at a respective strut. A spring is interposed between the expandable portion and a tip member which is spaced apart from a distal end of the expandable portion. In another exemplary embodiments, the device includes the expandable portion and the tissue modification element(s), and a balloon located between the struts, which when inflated, moves the struts into the second position.

Devices and methods are described for occluding the left atrial appendage (LAA) to exclude the LAA from blood flow to prevent blood from clotting within the LAA and subsequently embolizing, particularly in patients with atrial fibrillation. An implant is delivered via transcatheter delivery into the LAA. The implant includes a conformable structure comprising a foam body and internal support. The support includes anchors that penetrate the foam body and anchor the implant to the walls of the LAA. The implant provides compliance such that it conforms to the native configuration of the LAA.

Devices, systems and methods for treating diseases and disorders effecting the cardiovascular system of the human body are disclosed. An exemplary device in accordance with this disclosure comprises a shaft, tip member fixed to the shaft, and a probe extending beyond a distal surface of the tip member. In some useful embodiments, the tip member is relatively atraumatic and the probe is shaped so as to be more likely to produce trauma than the tip member.

The present disclosure is directed a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method may include providing a first intravascular device having a distal portion and at least one aperture and positioning the distal portion of the first intravascular device in the vascular wall. The method may further include providing a reentry device having a body and a distal tip, the distal tip having a natural state and a compressed state and inserting the distal tip, in the compressed state, in the distal portion of the first intravascular device. The method may further include advancing the distal tip, in the natural state, through the at least one aperture of the first intravascular device.

A retrograde blood flow occlusion flushing device includes a first catheter, and a second catheter. The second catheter is axially movable with respect to the first catheter. The second catheter has an inflatable balloon connected to an outer circumferential surface of the second catheter at the distal end of the second catheter. The balloon is movable between a collapsed state and an inflated state. The second catheter has a port in the sidewall between the proximal end of the balloon and the distal end of the balloon. The balloon has at least one port proximate the proximal end of the balloon. In the inflated state, fluid is deliverable through the lumen of the second catheter, through the port in the sidewall of the second catheter to inflate the balloon and at least some of the fluid exits the inflated balloon in the proximal direction through the port in the balloon.