A method for treating tissue of at least one of an internal carotid artery, an ophthalmic artery, or an ostium between the internal carotid artery and the ophthalmic artery of a subject may include expanding a first expandable device of a first device in the internal carotid artery. The method also may include delivering a second device in the ophthalmic artery via the first device and expanding a second expandable device of the second device in the ophthalmic artery. Further, the method may include adjusting a radial position of the second expandable device relative to the first expandable device.

A catheter includes a wave guide for transmitting ultrasonic energy from a transducer, and which is also rotated to facilitate enhanced disruption of the concerned obstruction in a transverse direction. Embodiments of waveguide include distal anchors that help focus the energy transmitted to a treatment site, and may also include a deployable filter that may open distal of the obstruction to capture any dislodged debris. Selectively inflatable balloons may cordon off a treatment site, and the wave guide may comprise a tube that may serve the dual purposes of inflating the balloon(s), as well as to transmit ultrasonic energy to an obstruction. A portion of an ultrasonic catheter may include plural curved portions to space an exposed portion of the wave guide away from the catheter body to enhance the vibratory action provided.

Embodiments of the invention include tools and methods for performing thrombectomy in patients' internal carotid arteries. A balloon guiding sheath in accordance with embodiments comprises an elongated 7-9 Fr sheath having a working section length of about ninety centimeters, an access port on a proximal end portion and a distal port on a distal end portion. A 6-8 Fr working lumen extends through the sheath between the access port and the distal port. An inflatable balloon is on the distal end portion of the sheath. An inflation lumen extends in the sheath between the balloon and an inflation port. The guiding sheath is configured with stiffness and other characteristics to enable direct insertion of the working length of the sheath into a patient's vasculature through an arteriotomy in the femoral artery, and to position the balloon in the internal carotid artery.

A lead delivery apparatus and a method of delivering a medical lead to an anatomic target site. The method includes inserting a hydraulic plug into an internal delivery lumen of a delivery shaft, and coupling a medical lead to the hydraulic plug. Hydraulic pressure is applied to the hydraulic plug through the delivery lumen, thereby moving the hydraulic plug toward an anatomic target site, and advancing the medical lead toward the target site.

Devices, systems and methods for treating diseases and disorders effecting the cardiovascular system of the human body are disclosed. An exemplary device in accordance with this disclosure comprises a shaft, tip member fixed to the shaft, and a probe extending beyond a distal surface of the tip member. In some useful embodiments, the tip member is relatively atraumatic and the probe is shaped so as to be more likely to produce trauma than the tip member.

Devices and methods are described for occluding the left atrial appendage (LAA) to exclude the LAA from blood flow to prevent blood from clotting within the LAA and subsequently embolizing, particularly in patients with atrial fibrillation. A foam implant is delivered via transcatheter delivery into the LAA and anchored using an internal locking system of the implant. The locking system includes deployable anchors that can be deployed after deployment of the foam implant from the delivery catheter and expansion of the foam within the LAA. The implant location can thus be verified before deploying the anchors to secure the implant. The locking system can be reversible to allow retraction of the anchors and repositioning or retrieval of the implant.

The present disclosure is directed to a device. The device may include a distal shaft defining a central lumen and an orienting element comprising at least one inflatable member. Wherein a first portion of the orienting element extending from the shaft in a first direction and a second portion of the orienting element extending from the shaft in a second direction. Further, wherein the second direction is substantially opposite the first direction.

A motor drive for a rotary medical device having at least one seal-set which comprises a bore defining bearing, a motor having an output shaft, a flexible shaft, having a diameter smaller than the bearing's bore, being power transmittingly and concentrically connected to the output shaft, a seal, defining a bore that is smaller than the flexible shaft's diameter, being mounted adjacent to the bearing with its bore concentric relative with the bearing's bore, wherein the flexible shaft passing through the bearing's bore which sufficiently deflects it to align it with the second bore to interferencingly fit through it and hydraulically seal it.

Devices, systems and methods for treating diseases and disorders effecting the cardiovascular system of the human body are disclosed. An exemplary device in accordance with this disclosure comprises a shaft, tip member fixed to the shaft, and a probe extending beyond a distal surface of the tip member. In some useful embodiments, the tip member is relatively atraumatic and the probe is shaped so as to be more likely to produce trauma than the tip member.

Systems and methods for minimally invasive treatment of target tissue among one or more passageways include a flexible elongate device, a tool including a first tubular member, and an instrument to perform treatment on target tissue around the target location. The flexible elongate device includes a proximal end, a distal end, and a lumen therebetween. The tool is configured for deployment within the lumen to a passageway exit site, puncturing a passageway wall at the passageway exit site, and deployment to a target location. The instrument is sized to be deployed within the tool. In some embodiments, the systems and methods further include an anchor configured to stabilize the tool. In some embodiments, the first tubular member is a first hollow sheath configured to be deployed past the distal end of the flexible elongate device to the passageway exit site.