A thrombectomy device includes a coring member configured to disintegrate a thrombus in a vessel into fragments from a proximal side of the thrombus and a catch member configured to be anchored at a distal side of the thrombus to provide embolic protection. The coring member and the catch member are operable independently of each other. Methods of removing a thrombus from a vessel employ a rotating coring device to disintegrate the thrombus into fragments.

Methods and apparatus are provided to facilitate the minimally invasive removal of tissue and to facilitate the direct approach to anesthetizing a body wall of a patient. A pull-type cutting device also is disclosed to introduce an opening into the body wall to provide access for intra-chest surgical interventions, for example a minimally invasive biopsy technique as also described for excising target tissue from within a patient, including a nodule from within the patient's lung.

A device (100) is presented for excision of a heart valve comprising a first (120) and second (140) clamping element in mutual sliding relation, each having an annular clamping surface (122, 142) which annular clamping surfaces (122, 142) mutually co-operate to form an annular clamping region (166) configured for clamping a heart valve annularly, and a slidable cutting element (160) slidable and rotatable with respect to the annular clamping region (166) configured to circularly excise the heart valve, wherein the slidable cutting element (160) is displaceable within an annulus of the annular clamping zone region (166).

A catheter is provided, which includes a cutting element having one or more raised elements. The cutting element has a cup-shaped surface at the distal end that may be smooth and continuous except for the raised elements.

A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes. A tool is provided to aspirate excess fluid and tissue from the treatment area.

A sheath comprises an elastomeric tube having a self-expanding scaffold coupled to a wall. The scaffold can expand to a diameter larger than the tube diameter to provide an enlarged distal opening. An aspiration catheter has a balloon and an aspiration port so that occlusive material can be removed from a blood vessel by drawing the balloon through the vessel while simultaneously aspirating through the port.

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

A capturing unit provided on a distal end of a second tube can be deformed into a contracted state and an expanded state, in which the capturing unit is deployed to form a capturing chamber. The capturing chamber has an opening area decreased as it goes from a distal end opening of the capturing chamber toward a proximal end opening of the capturing chamber. A third tube rotatable relative to the second tube and a cutting unit provided on a distal end of the third tube for cutting a foreign substance are arranged in a second lumen. In the expanded state of the capturing unit, the cutting unit is arranged more toward the proximal end opening of the capturing chamber than the distal end opening.

The present invention provides a tube body cleaning apparatus. A tube body cleaning apparatus according to the present invention comprises: a body having a set length and formed from a flexible material; a work member positioned at one point of the length direction of the body and rotatable, about a shaft provided in the length direction of the body, with respect to the body; and an expansion member positioned at one point of the length direction of the body and enabling a volume, which protrudes outward from the body, to increase by expanding.

A medical device for removal of an occlusion at an occlusion formation site in a vessel in a patient's body. The retrieval device having a retriever sub-system and an aspiration sub-system. The retriever sub-system having a delivery catheter and an elongated delivery member that includes proximal and distal expandable elements, the proximal element being removably engaged to the elongated delivery member and the distal element being fixed to the elongated delivery member. The proximal element adapted to move axially along the elongated delivery member in a distal direction toward the distal element when the proximal element is released from the elongated delivery member, whereby, when the proximal element is disposed on a distal side of the occlusion and the distal element is disposed on a proximal side of the occlusion, the proximal and distal elements surround, isolate and contain the occlusion between the proximal and distal elements at the occlusion formation site. The medical device also includes means for delivering pharmacological and biologically active agents to the vessel occlusion site during and after the occlusion extraction, the pharmacological agents are adapted to at least partially lyse and/or disassociate the occlusion from the vessel wall or ameliorate and/or facilitate amelioration of tissue damage to an endothelial luminal wall of the vessel, the biologically active agents are also adapted to ameliorate and/or facilitate amelioration of tissue damage to an endothelial luminal wall of the vessel. The aspiration sub-system adapted to remove at least a portion of the occlusion during extraction of the occlusion from the vessel.